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Biomedical subjects

G Debry

Publications and source records attributed to G Debry.

At least 91 records · Page 5Linked to original sources
PubMed1984

[Action of fenofibrate in hypercholesterolemic children. 18-month follow-up].

Twelve children with lla hypercholesterolaemia were given fenofibrate and examined after 6, 12 and 18 months of treatment. Cholesterol levels were measured both in whole plasma and in lipoprotein fractions after precipitation with concanavalin A. Plasma cholesterol and apoprotein B-bound cholesterol were reduced by 20% and 26% respectively (p less than 0.01). A non-significant 10% increase in apoprotein A-bound cholesterol was observed. These changes were effective at 6 months and persisted throughout the study. Fenofibrate was well tolerated and this, together with its effectiveness in lowering lipid values in hypercholesterolaemic children, suggests that it would be useful to achieve primary prevention.

Child↗
PubMed1984

Long-term evolution of the effect of bran ingestion on meal-induced glucose and insulin responses in healthy man.

The long-term effect (7 wk) of the addition in the diet of 20 g of wheat bran was studied in five healthy subjects. Blood glucose and plasma insulin were assayed during test-meals taking place before (I), then 10 days (II), 24 days (III), and 45 days (IV) after daily ingestion of wheat bran. Bran addition leads to a time progressive reduction of meal-induced glucose response. This effect was the strongest during meal III, at 30 min (from 7.38 +/- 0.11 to 5.0 +/- 1.11 mmol/l; p less than 0.05) and at 60 min (from 5.94 +/- 0.61 to 3.88 +/- 0.78 mmol/l; p less than 0.05). Insulin response remained identical during the first three test meals. It increased then in a significant manner during meal IV, at 60 min (From 45.5 +/- 12.3 to 61.8 +/- 8.9 microU/ml; p less than 0.02), and at 120 min (from 41.2 +/- 16.3 to 61.0 +/- 16.0 microU/ml; p less than 0.05). The causes of the reduction of glucose response could be potential gastric emptying and intestinal transit increases. The exact mechanism of the improved long-term glucose tolerance seen in brain is not obvious nor is the reason for the enhanced insulin response seen later.

Adult↗
PubMed1984

Postheparin lipolytic activities in Zucker rats fed with sucrose- or cornstarch-rich diets.

In order to study the metabolic effect of dietary sucrose or cornstarch on plasma total triglyceride lipase (T-TGL), hepatic triglyceride lipase (H-TGL) and monoglyceride hydrolase (MGH) activities, young male Zucker fatty and lean rats were pair-fed or fed ad libitum for 4 weeks with diets containing 68% carbohydrate as either sucrose or cornstarch. Our results show that ad libitum feeding of fatty rats with both diets produced an intensification of plasma hypertriglyceridemia which was accompanied by high levels of all plasma postheparin lipolytic activities. These diets did not affect the enzyme activities of lean littermates. Pair-feeding the fatties with sucrose-rich diet produced an increase in T-TGL, H-TGL and MGH. If cornstarch was the carbohydrate included in the diet no difference in postheparin lipolytic activities was found between phenotypes.

Animals↗
PubMed1984

Effect of carbohydrate diet type upon obesity and hyperlipemia in the Zucker fa/fa rat.

20 fa/fa Zucker rats were submitted to a normalization of their food-intake energy level by pair-feeding using control Fa/-rats, for 4 weeks. Two diets were tested. The first was a starch-based diet (A) (66% starch w/w) and the second a sucrose-based diet (S) (66% sucrose w/w). The food-intake levels and the efficiency of storage of energy were thus comparable for the two diets. Though the fa/fa hyperinsulinemia decreased for the 4 weeks of experiment and was comparable with the (S) and (A) diets, the hypertriglyceridemia was lower with the (S) diet than that for the (A) diet. This could be in relation to the increased post-heparin lipase activity in the (S) diet, compared to the (A) diet.

Animals↗
PubMed1984

28-hour profiles of blood glucose (BG), plasma immunoreactive insulin (IRI) and IRI/BG ratio in four insulinomas.

Nycthemeral variations in blood glucose (BG) and insulinemia (IRI) of four subjects with insulin-secreting pancreatic tumors were determined. Blood samples were drawn every 15 min over a 28-h period. After surgery, two of the subjects were retested. Meals were distributed during testing so that there was a minimum of eight meals per test. The meals before and after surgery were qualitatively, quantitatively and chronologically the same. Even though the circadian profiles of the glycemia and insulinemia varied greatly among the subjects, there were three common characteristics during the noctural period (24 h-8 h): Existence of one or several phases of at least 1 hour where the glycemia was less than 2.78 mmol/l, Existence of IRI peaks, without eating. Existence of a peak or of increased values (as compared to normal values) of the IRI/BG ratio, without eating. The IRI/BG ratio is a very sensitive index for insulin secretion dysfunction as compared to glycemia. The results suggest that the measurement of glycemia and insulinemia of sleeping subjects and then calculation of the IRI/BG ratio is sufficient to affirm the presence of an insulin-secreting adenoma.

Adenoma, Islet Cell↗
PubMed1984

[Feasibility and reproductibility of a euglycemic hyperinsulinic glucose clamp technic].

The euglycemic hyperinsulinaemic clamp is a means for the study of insulin sensitivity. Several techniques have been described: some are manual, others are automatic and use hypertonic glucose (50%). A semi-automatic technique is described using an artificial B cell (Biostator Miles) and a pump (Vial). The method and its reproductibility in ten healthy subjects were studied. The choice of appropriate algorithms ensure a constant and stable insulin level of 93,3 +/- 5 uU/ml and good glycemic feedback through graduated glucose perfusion. The use of a supplementary pump in series with an artificial pancreas insures basic glucose input without recourse to strong concentrations (20%); glycemic feedback of the artificial pancreas is thereby dynamically controlled. The glucose requirement is 8,08 +/- 0,73 mg/kg/min. The same values are found in the same patients three weeks later and resemble those obtained using other techniques. Automatic feedback makes the technique objective; low concentration glucose solution avoids damage to veins.

Adult↗
PubMed1984

Influence of diet composition on obesity, hyperlipemia and liver steatosis in Zucker fa/fa rats pair-fed with Zucker Fa/- rats.

The effect of a four-week experiment on ten fa/fa Zucker rats (aged seven weeks at the beginning) fed on a lipid-rich diet (HL: 31 per cent w/w lipids, 45.6 per cent starch) was compared to that of a control diet (C: 10 per cent lipids, 66 per cent starch) on control Fa/- rats using a special pair-feeding apparatus that made it possible to obtain an identical intake rhythm. Energy level of the intake was significantly higher for the HL diet than for the C diet. At the end of the experiment, fa/fa rats remained obese and hyperlipemic, and still showed liver steatosis. With equal energy levels ingested, the obesity of fa/fa rats was comparable for both diets; hypertriglyceridemia and hypercholesterolemia were identical for both diets. When compared to the C diet, the HL diet modified neither their obesity nor their hyperlipemia. Obese rat liver on the HL diet showed lower levels for triacylglycerols, cholesterol, GGT, ALT, LDH and aldolase activities, while hepatic glycerol kinase and AST activities were higher than and comparable to, respectively, the C diet. Thus the HL diet led to a decreased liver steatosis for fa/fa rats as compared to the C diet.

Animals↗
PubMed1984

[Effect of a 36-hour fast on blood glucose and insulin responses to the glucose stimulus in the normal subject].

The authors show that it's been able to perform an oral glucose tolerance test on subjects after an 36 hrs 'fasting, providing that a feeding with 250 g of carbohydrates has been brought on the three days before fasting. Three oGTT were performed on 10 normal subjects and carried out as follow: the first after a 3 days' period of usual food intake, the second after a 36 hours 'fasting, the third after a new three days' period with the usual food intake. The first and the third glycemic and insulinemic responses to oGTT are not significantly different. However, after the third period, weight, triacylglycerolemic rate and fasting blood sugar levels are still significantly below the initial values.

Adult↗
PubMed1984

[Plasma glucose and C-peptide after ingestion of sucrose and starch in controlled insulin-dependent diabetics. Importance of glucose availability].

Oral tests using 50 g of sucrose and 100 g of white bread were carried out in ten insulin-dependent diabetics (four with signs of residual B-cell function and in six without). Plasma glucose and C-peptide (CPR) were estimated during the 180 minutes after ingestion. After bread intake, plasma glucose increase was significantly delayed (30 min.). Hyperglycemia (greater than 2.5 g/l) lasted significantly longer after bread then after sucrose ingestion. Blood glucose decreased more quickly in subjects with residual B-cell function than in subjects without. CPR was not significantly modified by either of the carbohydrate loads. In the controlled insulin-dependent diabetic the hyperglycemia observed results from the ease of carbohydrates hydrolysis and from the amount of available glucose. The role of fructose seems weak in the case of sucrose because its conversion to glucose would be minimized in the presence of metabolic normalization as indicated by a well controlled blood glucose.

Adolescent↗
PubMed1984

[Reference values of plasma and lipoprotein cholesterol and triacylglycerols in healthy children].

A sample of a reference population was selected from an all-inclusive population by a method based on strict physiological and clinical criteria. Sociological and ethnic factors as well as the biological plasma evaluation of the parents were used as family exclusion parameters. Cholesterol and triacylglycerols were measured in total plasma as well as in each lipoprotein fraction isolated by ultracentrifugation. The values are described as functions of sex and age. Total cholesterol varied little with age and sex. It is higher in girls except for HDL values. The maximum difference between boys and girls (age group 15-19 yrs) is mainly due to LDL-bound cholesterol. Plasma triacylglycerol values are generally higher in girls than in boys, particularly for VLDL. The minimum difference is in the age group 15-19 yrs.

Adolescent↗
PubMed1984

Feeding frequency and nitrogen balance in weight-reducing obese women.

In a prospective trial, ten obese women, each her own reference, ate a 1200 kcal/d slimming diet in six meals a day compared with three meals a day during two 14-d periods. Loss of weight was slightly greater during the six-meal periods when loss of nitrogen was lower and thus loss of lean mass was also lower.

Adolescent↗
PubMed1984

[Morphometric study of hepatic peroxisomes in hyperlipoproteinemic patients treated with fenofibrate].

In rodents fenofibrate shares with other triglyceride-lowering agents the potential to increase the liver peroxisome population. It was therefore of interest to look for this effect in hyperlipoproteinemic patients receiving this drug. Light and electron microscopy of liver biopsies from a group of 10 patients treated with fenofibrate and from another group of 13 receiving diet only, show no morphological difference between both groups. In contrast with the rodent data the morphometric study reveals no significant changes in the number (fenofibrate group: 7.96 10(10) cm-3; group receiving diet alone: 8.41 10(10) peroxisomes per cm3 of liver tissue) or in the size (fenofibrate group: diameter = 0.53 +/- 0.07 micron; group receiving diet alone: 0.50 +/- 0.06) of peroxisomes. The difference between our results and those obtained consistently in rodents may be due to the relatively low dose in man and/or a species-dependant difference in enzyme content of liver peroxisomes, itself related to an apparent difference in the way in which lipids are handled.

Adult↗
PubMed1983

[Dietetic treatment of hyperlipoproteinemias].

The authors mention the previous conditions to the prescription of a diet for primary hyperlipoproteinemia : definition of the metabolic disease and of its nutritional dependence, precise knowledge of earlier nutritional uses, demonstration of vascular risk factor linked to the hyperlipoproteinemia, i.e. obesity which always requires a hypocaloric diet. A low cholesterol and saturated fatty acid diet reduces by 10% the cholesterolemia, and sometimes exempts from use of medical drugs in moderate hypercholesterolemia. The exceptional hyperchylomicronemia are reduced by drastic reduction of the lipid fraction of the diet, which is compensated by use of MCT. The dietetic treatment of endogenous hypertriglyceridemia depends on their nutritional dependence : an alcohol dependence implies a complete suppression of alcoholic drinks. A glucid dependence implies the suppression of simple carbohydrates and a reduction of the glucidic fraction of the diet.

Carbohydrate Metabolism↗