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Biomedical subjects

F Schulze

Publications and source records attributed to F Schulze.

At least 55 records · Page 3Linked to original sources
PubMed1986

The association between serum Lp(a) concentrations and angiographically assessed coronary atherosclerosis. Dependence on serum LDL levels.

Lipoprotein(a) concentrations were measured by radial immunodiffusion in a cohort of 40-60 year males who had been classified by coronary angiography as CAD+ with 50% stenosis of one or more of the major coronary arteries or CAD- with no signs of coronary lesions. Sample odds ratios were calculated as a measure of association between serum Lp(a) values and the presence of coronary artery disease. An odds ratio of 2.706 (P less than 0.001) was derived for elevated (greater than or equal to 30 mg/dl) Lp(a) levels vs low (less than 5 mg/dl) Lp(a) levels indicating a strong association between the presence of coronary artery disease and elevated Lp(a) concentrations. This association was independent of the known risk factors smoking, hypertension and diabetes as well as the serum concentrations of total triglycerides, HDL-cholesterol, alpha-Lp-cholesterol and pre-beta-Lp-cholesterol. In contrast to these variables the association between Lp(a) and coronary artery disease was dependent upon the serum concentrations of LDL-cholesterol, beta-Lp-cholesterol and total cholesterol. At concentrations below the respective median for each variable, odds ratios of between 1.42 and 1.67 were calculated whereas at concentrations above the respective medians the odds ratios ranged from 4.50 to 6.33 (P less than 0.001). Our data, therefore, suggest that increasing LDL concentrations markedly increase the risk of coronary artery disease due to elevated Lp(a) levels.

Adult↗
PubMed1985

[Keratectomy and cataract extraction in Terrien disease].

In a 36-year-old patient with bilateral Terrien's disease, surgery to improve vision in the right eye, which was in Stage V, was no longer possible. In Stage III a thoroughgoing keratectomy parallel to the limbus was performed, in combination with cataract extraction and coreplasty. Even though Descemet's membrane was absent in the dystrophic corneal region, optimal healing was achieved by wound closure with a combination of biosutures, monofil sutures, and "Tissucol" biological tissue cement. The keratectomy reduced the corneal astigmatism from 11 to 4 D. With corrective lenses the patient regained a visual acuity of 0.4 in the left eye. The histological findings are discussed.

Adult↗
PubMed1985

Mutational analyses of the Moloney murine sarcoma virus enhancer.

Retroviral enhancers seem to play an integral role in determining tissue tropism. In an attempt to define the sequences essential for Moloney murine sarcoma virus (Mo-MSV) enhancer activity, we have undertaken deletion and insertion mutational analyses of the 72-bp repeats. We demonstrate that, in contrast to simian virus 40 (SV40), the proximal 19 bp of the 72-bp unit of Mo-MSV are not essential for enhancer function in mouse fibroblasts. Our analysis further localizes the 5' boundary of the Mo-MSV enhancer to a 5'-CAGGAT-3' region.

Acetyltransferases↗
PubMed1981

[Myoglobinuria in malabsorption after small bowel resection].

A patient with subtotal small bowel resection after mesenterial vein thrombosis presented with muscular weakness and pain. An increase in the activities of enzymes of muscular origin and of myoglobin in serum was found and myoglobinuria was detected. Muscle damage in this patient is attributed to electrolyte disturbances following extensive small bowel resection.

Aged↗
PubMed1981

[Diarrhea in young calves. 4. Redox potential of the gastrointestinal tract of clinically healthy calves, and calves with spontaneous diarrhea, experimental Escherichia coli infection, and cyclophosphamide treatment].

The redox potential (ROP) dropped strongly in a calf, from two hours after birth to 48 hours of age. The drop in the colon was more strongly pronounced than that in the small intestine. -The Eh values recorded throughout the small intestine of clinically intact calves, aged between four and ten days, were more negative than those in the stomach. The most negative ROP values, which differed with significance from those of all proximal gastro-intestinal sections, were recorded from the caecum. -Intracolonic negativation of ROP in calves, during the first hours of life, must be attributed to progressing germ population. The same relationship is borne out clearly by a pronounced rise in anaerobic germ count accompanied by significant ROP negativation in the colon. -Growing age was accompanied by drastic change in ROP values throughout the gastro-intestinal tract. Calves aged between six and nine weeks were compared to animals aged between four and ten days. ROP values in stomach, proximal and distal jejunum as well as in the ileum of the former group were negative with significance, whereas ROP values in the caecum and colon of the same group were more positive. -Animals with diarrhoea exhibited significant ROP deviations only in the ileum. They were more negative, as compared to clinically intact calves aged between four and ten days. Pathophysiological intestinal disorders which could be measured via ROP were found to play no role at all in the genesis and course of diarrhoea of calf. -No pronounced gastro-intestinal ROP deviations were exhibited by calves with experimentally induced Escherichia coli infection and manifest coli dysentery nor by animals which received cyclophosphamide treatment.

Animals↗
PubMed1981

[Redox potential of the gastrointestinal tract of swine of different ages].

The redox potential (ROP) was found to undergo negativation in all gastro-intestinal sections of piglets, from the time of birth to the age of three days. Negativation was relatively low in the small intestine, but it accounted for more than 300 mV in stomach and colon. ROP values recorded from stomach and rectum of weaned piglets were more negative with significance than those established from animals before weaning. ROP, as an important environmental factor in the gastro-intestinal tract, did not undergo significant change due to weaning which might support any conclusion as to pathogenesis of coli-enterotoxaemia, in spite of the implied change of feeding and keeping conditions. ROP in store pigs was found to be more or less one and the same, except for more positive values in the proximal jejunum, with most negative values being recordable from the stomach. Progressing age was found to be accompanied by sizeable ROP change in the gastro-intestinal tract of swine. ROP values in the distal jejunum and ileum of sows were more negative with significance than those recorded from store pigs, but values were more positive in the colonic cone and rectum. Unambiguous ROP negativation in the proximal and distal jejunum and ileum as well as in the gastro-intestinal tract of sows was accompanied only by moderate rise in overall anaerobic germ count. ROP values recorded from the colonic cone and rectum, where highest germ counts were detectable, were more positive than those recorded from any other intestinal section. Hence, gastro-intestinal ROP of sows is, probably, not controlled by metabolism of the germ flora.

Aging↗
PubMed1980

[Quantitative makeup of the gastrointestinal flora of piglets in the 1st 2 weeks of life. 2. The development of the gastrointestinal flora in primary specific-pathogen-free piglets].

Quantitative germ flora analyses were applied to 22 SPF piglets, aged between four hours and 14 days, to follow up the development of their gastro-intestinal flora. The development of a fairly stable gastro-intestinal flora was delayed. Escherichia coli strains were isolated from SPF piglets which had died following diarrhoea and septicaemia, but they did not fall in those E. coli sero-groups known for pathogenicity to swine. The outcome of raising was greatly stabilised and amounted to about 70 per cent by administration of something between 80 ml and 100 ml of radiation-sterilised sow colostrum.

Aging↗
PubMed1980

[Lysozyme in sow's milk and its importance to bacterial population of the gastrointestinal tract in suckling piglets].

The lysozyme level was found to reach its highest point on the second day from parturition, followed by strong decline to a much lower value which then remained constant up to the 30th day of lactation. The rise recorded from the period between farrowing and the second day after birth as well as the decline up to the fourth day and the constant level up to the 30th day from parturition were statistically secured. Lysozyme levels in the milk of sows with no previous lactation record was found to be lower with significance than those recordable from sows with something between six and nine previous lactations. The conclusion has been that lysozyme levels are strongly affected by both lactation time and number of lactations. Lysozyme concentrations in sow milk on the first and second days from parturition were betweeen 6.8 and 11.0 microgram/ml, depending on the number of previous lactations. Such high lysozyme levels in sow foremilk over the first three days of age as well as all findings so far gained on the structure of bacterial cell walls are likely to suggest that the above enzyme affects bacterial population of the gastro-intestinal tract of suckling.

Animals↗
PubMed1980

[Lysozyme levels in gastrointestinal mucous membrane extracts of swine and their response to immunization with Escherichia coli mutants].

Pigs of various age groups were found to have lyzozyme in all segments of the mucous membrane of the digestive tract, though typical Paneth's cells were absent. While no significant difference was found to exist between gastro-intestinal lyzozyme concentrations in store pigs, on the one hand, and sows, on the other, lyzozyme levels in piglets before weaning were found to differ by positions. Those in the distal jejunum were significantly higher than the proximal jejunum values, while the large intestine levels were below those of the ileum. The lyzozyme concentrations in all intestinal sections of store pigs were significantly in excess of those in piglets before weaning, all except for the stomach level. The proximal and distal jejunum and large intestine values and concentrations of that ferment in sows were lower than those in store pigs. Lyzozyme concentrations in the mucous membrane of the small intestine and in the lymph nodes of weaned piglets could not be raised by intraperitoneal nor oral immunisation, using Smd Escherichia coli mutants of serogroup O149:K91(B), K88ac. The above findings are discussed under the aspect of new insights into the importance of lyzozyme to local defence in the gastro-intestinal tract.

Aging↗
PubMed1980

[Studies of diarrhea in young calves. 3. Effect of cyclophosphamide on histomorphology and microbial flora of the gastrointestinal tract in the calf].

One single intravenous injection of 60 mg/kg of cyclophosphamide caused the development of moderate to medium catarrhal enteritis in calves, within two to four days from injection. --Distally aggravating damage to epithelial cells in the small intestine, accompanied by shortening of villi, as well as usually complete lymphocyte depletion of the lymph follicles of Peyer's patches were the most conspicuous pathohistological findings obtained from the intestinal tract. Regular epithelial damage, including ulcerations and necroses, were recordable also from the colonic mucous membrane. --No remarkable change in the gastro-intestinal flora was recordable from calves killed two days from cyclophosphamide application, but the quantitative composition of the gastro-intestinal germ flora was found to be remarkably altered in those animals which had been killed four days after administration of the cytostatic. --Elevated coli counts in the rumen as well as in the proximal and distal parts of the jejunum and ileum and reduced anaerobic overall germ counts and bacteroides values in the cecum and rectum were the most conspicuous bacteriological findings. --The direct damaging action of cyclophosphamide on the mucous membrane as well as altered immunological reactivity of the experimental animals should be considered the triggering factors which actually caused considerable displacement in the quantitative composition of the gastro-intestinal flora in those calves which had been killed four days after cyclophosphamide application.

Animals↗
PubMed1979

[Effect of reduced gastrointestinal motility on the regulation of gastrointestinal flora and the pathogenesis of coli enterotoxinemia in market swine].

Opium tincture and Spasmentral were applied to piglets early after weaning and reduced their gastro-intestinal motility, which, however, caused only very minor changes in quantitative germ flora composition in those first days. Short-time suppression of gastro-intestinal motility obviously does not result in detrimental consequences to the organism as a whole, since there seem to be several factors which are involved in the control and regulation of the intestinal germ flora. Impairment of gastro-intestinal motility appeared to be of no importance to the pathogenesis of coli-enterotoxaemia, as it was not followed by higher incidence of the disease.

Animals↗