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Biomedical subjects

F Salomon

Publications and source records attributed to F Salomon.

At least 91 records · Page 5Linked to original sources
PubMed1983

Sinus pauses in early human malnutrition during waking and sleeping.

7 malnourished infants were studied before and after nutritional rehabilitation through long term polygraphic recordings during waking and sleeping. High amounts of sinus pauses (R-R interval comprised between 20 and 90% of the preceding interval) have been found in malnourished infants, mainly during quiet sleep. After the nutritional rehabilitation there is a dramatic reduction. The high amount of sinus pauses in infants suffering from severe malnutrition may reflect a disturbance of neurovegetative regulation, which is enhanced by sleep.

Arrhythmia, Sinus↗
PubMed1983

[pH and buffer capacity of cerebrospinal fluid after spinal anesthesia].

In 20 patients, undergoing total hip or knee replacement, we studied pH and metabolic changes in the C.S.F. following spinal anaesthesia with two different mixtures of bupivacaine 0.5% and mepivacaine 4% hyperbaric. Our study was made with special regard to the early changes; therefore C.S.F. specimens were obtained at 1, 3, 5, 10, 20, 30, 60 and 90 min intervals and analyses of pH, pCO2, HCO3 and BE estimations were carried out immediately after each obtained sample. Our results showed a marked tendency towards acidosis and therefore do not comply with previous studies. The advantage of this fact is an improved stability of bupivacaine in C.S.F.

Aged↗
PubMed1982

Developmental trend of quiet sleep is altered by early human malnutrition and recovered by nutritional rehabilitation.

Thirteen infants malnourished from birth have been recorded with polygraphic techniques continuously for 24 h. The developmental trend of Quiet Sleep was found to be altered; infants older than 4 months had a diminution of Quiet Sleep with shorter phases. Ambiguous Sleep was increased. These findings reflect the effects of malnutrition on central nervous system development and could have implications for growth and for anabolic processes. Nutritional rehabilitation performed through an intracave catheter led to an increase of Quiet Sleep and to a decrease of Ambiguous Sleep.

Child Development↗
PubMed1982

Primary adrenocortical nodular dysplasia with Cushing's syndrome and cardiac myxomas. A peculiar familial disease.

In a family with 4 children, 2 had slowly developing Cushing's syndrome and were adrenalectomized between the ages of 18 and 28 years. As in other cases with familial Cushing's syndrome, primary adrenocortical nodular dysplasia, the so-called adrenocortical adenomatosis, was demonstrated. The brother, now 39 years old, is in good health. The sister, however, died at the age of 36 years. Autopsy revealed a cardiac myxoma of the left atrium. A cardiac myxoma had been found incidentally at autopsy of these two patients' oldest brother, a boy who died at the age of 4 years. Both siblings with Cushing's syndrome presented additional Peutz-Jegher-like hyperpigmentation and myxomatous tumours of the skin. Identical observations of familial adrenocortical nodular dysplasia, Cushing's syndrome and cardiac myxomas have not been reported to date. However, the familial occurrence of cardiac myxomas and adrenocortical dysplasia in combination with bilateral large cell calcifying Sertoli cell tumours of the testis has been published recently.

Adrenal Cortex Diseases↗
PubMed1982

Sleep related growth hormone and prolactin secretion in children during constant rate enteral nutrition.

The aim of this study was to investigate the nocturnal secretion of growth hormone and prolactin in a particular model where nutrients are delivered continuously. Six children with severe intestinal diseases undergoing total constant rate enteral nutrition for 1.5 to 8 months have been studied; all children had a normal nutritional status at the time of the recording. Sleep patterns were studied by the usual polygraphic methods from 10 p.m. to 8 a.m. Blood samples were taken every 20 min through an indwelling catheter for growth hormone and prolactin plasma level determination. Several growth hormone peaks were observed with a peak always secreted in connection with stage III-IV of the first cycle. This early peak was significantly higher than the following ones. Nocturnal patterns of prolactin secretion showed individual differences characterized by a series of episodic releases which consisted of a few long rises (4 patients) and several small fluctuations; no correlation was found with the sleep patterns; no increase in the level throughout the night was observed. Loss of the rhythmicity of alimentation does not alter the secretion of growth hormone during sleep.

Adolescent↗
PubMed1982

Immune complex orchitis in infertile men. Immunoelectron microscopy of abnormal basement membrane structures.

Testicular biopsies from 30 patients with fertility disorders were investigated by peroxidase-labeled antibodies against IgG and C3 at an ultrastructural level. Three types of abnormal basement membrane structures (ABMS) proved to be positive. Immune-type deposits (ABMS type 2), ABMS with vesicular particles (ABMS type 4), and those with membranous structures (ABMS type 5) stained positively for IgG and C3. In 21 cases ABMS were positive for at least one of the antisera. Two additional cases showed a linear reaction for IgG and C3 in the basement membrane. According to the number and size of positive ABMS, the cases were divided into three groups. Group I contained 10 cases with extensive ABMS types 2, 4, and 5 positive for IgG and C3 and two cases with linear positivity. At light microscopy, the changes varied from light to severe tubular atrophy. In these latter cases ABMS types 4 and 5 predominated, whereas in the light and focal tubular lesions ABMS type 2 did. In group II, eight cases revealed few and small ABMS positive by immunoelectron microscopy and no more than slight tubular changes at light microscopy. In group III, minimal or no ABMS were present, but in three cases mast cells were numerous in the interstitial tissue. The demonstration of immune deposits in the basement membrane of seminiferous tubules is interpreted to be the result of an antibody-mediated damage to the germinal epithelium leading to tubular atrophy. In one case obstruction of the sperm ducts and in another torsion of the testis are incriminated as events triggering the autoimmune process. Linear staining of the basement membrane for IgG and C3 in two cases suggests the development of antibasement membrane orchitis.

Adult↗
PubMed1982

Abnormal basement membrane structures of seminiferous tubules in infertile men.

Testicular biopsies from 60 patients with impaired fertility were investigated by electron microscopy for changes in the basement membrane of seminiferous tubules. Six different types of abnormal basement membrane structures (ABMS)--analogous to those of glomerular basement membrane disease--have been found to a variable extent in biopsies of 33 cases. The occurrence of ABMS correlated with the severity of tubular changes, and ABMS were absent in tubuli seminiferi with an intact germinal epithelium. Except for ABMS type 2, thought to represent immune complex deposits, the origin of ABMS is unknown. ABMS type 2 was present in 21 cases. Since similar deposits have been observed in rabbits developing immune complex orchitis after vasectomy, our findings indicate the occurrence of immune complex orchitis in infertile men.

Adult↗
PubMed1981

Weight changes and sleep organisation in infants.

We have studied the relationship between weight changes and polygraphically recorded sleep, during a 24 hour period, of 26 infants aged between 2 and 11 months. Weight changes (in percentage within a period of 24 h) have been found to be correlated with the following sleep parameters: total amount of ambiguous sleep, percentage of time spent in cycle of the total sleep time, mean length of the cycles. We speculate that this relationship could be important when weight variations do not proceed as expected only on the basis of the clinical conditions and the caloric intake.

Body Weight↗
PubMed1981

[Sleep onset in infants under continuous feeding from birth: 24 hour recordings (author's transl)].

The distribution in the 24 h period and the electrophysiological patterns of sleep onset have been studied in 18 infants fed continuously from birth to the age of between 1 month 2 weeks and 8 months 2 weeks. Continuous feeding modified neither the number nor the distribution of sleep onsets in the 24 h period. However, some differences with a control group did occur. The number of quiet sleep onsets in younger infants and of paradoxical sleep onsets in older infants were increased in continuously fed infants. In addition, the pattern of sleep onset in continuously fed infants bore no relation to the duration of the waking period preceding it, in contrast to the control group.

Circadian Rhythm↗
PubMed1981

[EEG sleep activity in a phenylketonuric child of the 'new variant' type, before and after treatment with 5-HTP and L-DOPA (author's transl)].

The EEG during the sleep of a 'new variant' (having a dihyropteridine reductase deficiency) phenylketonuric child, aged 11 months, has been studied under low phenylalanine and following a substitute treatment with 5-HTP and L-DOPA. Prior to treatment, a paroxystic type of activity composed of spikes and/or polyspikes associated with sharp theta waves was chiefly observed during paradoxical sleep (PS). After a 10 day treatment with 5-HTP and L-DOPA, the EEG was not modified. However, after 6 months of this therapy, the paroxysms disappeared as well as the spindles; the quiet sleep trace was disorganized. The EEG modifications observed could be due to an evolution of the illness, if the substitute treatment was begun too late to go into effect.

Electroencephalography↗
PubMed1981

Familial systemic lupus erythematosus and C4 deficiency.

A heterozygous state for C4 deficiency was found in 14 members of a family with familial SLE. The HLA analysis in this family permitted us to re-establish the linkage assumed to exist between the gene (or genes) controlling the synthesis of the fourth component of the complement and the major histocompatibility complex. In addition, it was found that the complement deficiency is not necessarily associated with any serological or clinical abnormality. The heterozygous state for C4 deficiency can be added to the various serological abnormalities described in asymptomatic members of families with familial SLE. It is as yet unknown whether this deficiency may predispose to the subsequent development of SLE.

Adolescent↗
PubMed1980

Sleep patterns in infants under continuous feeding from birth.

Continuous parenteral or enteral feeding of infants with major gastrointestinal problems (prolonged diarrhoeas, inflammatory digestive illnesses, anatomical anomalies necessitating surgical intervention, etc.) brings about a prolonged modification in nutritional and environmental conditions. The consequence of eliminating the feeding rhythms of the waking-sleeping rhythm in 16 infants between 1 and 8 months old were studied. In most of the infants the duration of sleep was close to that given by Kleitman in normals. Slightly decreased in 4 of the infants, these durations never showed significant differences from normative values. No delay was observed in the maturation of sleep patterns. The percentage and mean length of periods of quiet sleep were practically identical for all infants but a number of them showed large amounts of ambiguous sleep. The fact that none of these values evolved with age should be stressed. Paradoxical sleep periodicity was similar to that of normal infants, while the quiet sleep-paradoxical sleep cycles were shorter. In conclusion, the absence of feeding rhythms appeared not to modify greatly the sleep maturation and organization.

Cerebral Cortex↗
PubMed1980

[The spectrum of supravalvular aortic stenosis: clinical findings of 150 patients with Williams-Beuren syndrome and the isolated lesion (author's transl)].

The clinical findings of 150 patients with supravalvular aortic stenosis are presented. No correlation was found between the clinical findings and the hemodynamic degree of severity, with the exception that an ECG of left ventricular hypertrophy and strain was more common in patients with a LV pressure above 200 mm Hg. In this latter group of patients there is a significantly higher number of patients without the typical appearance of the Williams-Beuren syndrom. The analysis of the additional anomalies and mental retardation in the Williams-Beuren syndrom and the isolated cardiac lesion shows clearly that no distinct separation between these 2 groups is possible. This points towards the same pathogenesis.

Aortic Valve Stenosis↗