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Biomedical subjects

F Salomon

Publications and source records attributed to F Salomon.

103 records · Page 6Linked to original sources

[Experimental hepatic encephalopathy. Study of the organization of a diurnal sleep pattern in rats with portocaval anastomosis].

The organization of the diurnal sleep pattern was studied in control rats and in rats with end-to-side portocaval shunt before operation and during five weeks after operation. In control rats, no modification of the states of sleep was observed during the experimentation. In shunted rats, the total duration of waking increased, the total duration of slow wave sleep and paradoxical sleep decreased. The number of phases of waking and slow wave sleep increased and the number of phases of paradoxical sleep decreased. The mean duration of the phases of slow wave sleep decreased. These results show that the electrophysiological expression of experimental hepatic encephalopathy is similar to the electroclinical expression of hepatic encephalopathy in man and the polygraphic study of sleep disturbances permits the description of the encephalopathies.

Animals↗

[Continuous feeding and the waking-sleeping rhythm in children].

Twelve children aged 1 to 8 months with severe intestinal disorders that had necessitated treatment from birth with continuous parenteral and/or enteral nutrition were recorded for 24 hours. The analysis of the EEG, their behaviour and their activity showed that the distribution of sleep and movement during the night was similar to that of normal babies fed on demand. The total duration of sleep and the longest sustained sleep were slightly reduced. The authors think that the suppression of feeding rhythms do not alter the pattern of waking and sleeping.

Electroencephalography↗

[Experimental hepatic encephalopathy. The effect of portocaval shunt on the evolution of the anterior hypothalamic neurosecretion in the rat (author's transl)].

The evolution of the anterior hypothalamic neurosecretion is studied in control, sham-operated and portocaval shunt rats. In sham-operated related to control rats, no modification of the anterior hypothalamic neurosecretion is observed. In portocaval shunt rats, the hypothalamic neurosecretion increases. This increase is mainly observed into the median eminence in all the portocaval shunt rats. The hypothesis according to which the modification of neurosecretory acitivity of the hypothalamic structures may be related to a discrepancy between the central monoamines is discussed.

Animals↗

Experimental hepatic encephalopathy. Changes of the level of wakefulness in the rat with portacaval shunt.

The level of wakefulness in rats with portacaval shunt has been evaluated by measurement of the reactivity of the reticulocortical system by electric stimulation of the brain stem reticular formation during slow wave sleep. The voltage level of stimulus necessary to provoke cortical awakening is significantly decreased after portacaval shunt. This modification of the level of wakefulness is in accordance with the diminution of total sleep and the decrease in threshold of reaction to painful stimuli observed in rats after portacaval shunt. The measurement of the reactivity of the reticulocortical system is a simple procedure which permits quantification of post-shunt encephalopathy in the rat.

Animals↗

[Experimental hepatic encephalopathy. Central nervous system excitability in rats following portacaval anastomosis].

The excitability of reticulo-thalamo-cortical and reticulo-cortical system (RtCS) was studied by electrical stimulation of reticular formation during waking, slow wave sleep and paradoxical sleep during five weeks in control rats and in rats with portocaval shunt. In control rats, no modification of the excitability of RtCS was observed during the experimentation. In rats with portocaval shunt and from the fourteenth post-operative day, the excitability of RtCS was decreased during waking. All along the post-operative period, the excitability of RtCS was increased during slow wave sleep. No modification of the excitability of RtCS was observed postoperatively during paradoxical sleep. These modifications of the excitability of RtCS during waking and slow wave sleep could be related to quantitative variation of the waking-sleep cycle that have been described in rat with portocaval shunt. Their responsability in the disorganization of the waking-sleep states during the experimental hepatic encephalopathy may be hypothetized.

Animals↗

[Measurement of the excitability of reticulo-cortical and reticulo-thalamo-cortical system during different states of wakefulness and sleep in the rat: technique, results and application (author's transl)].

The measurement of excitability of reticulo-cortical and reticulo-thalamo-cortical system (RtCS) is realized in rats during the careless waking state, during slow-wave sleep and during paradoxical sleep and the ratio existing between these different levels of excitability is calculated. During the inattentive waking state, the excitability of RtCS is slightly higher than during the slow-wave sleep. During the slow-wave sleep, the excitability of RtCS is higher than during the paradoxical sleep. The calculation of the ratio and the relation existing between the three principal levels of excitability of RtCS allows to define the "constant of excitability" which can be utilized in the experimental investigations of the central nervous system. In discussion, the principal interpretations of the results are given.

Animals↗

Primary angiosarcoma of the pulmonary arteries: dynamic contrast-enhanced MRI.

PURPOSE: Our goal was to assess the MR appearance and histologic correlation of primary pulmonary artery angiosarcoma. METHOD: Four patients with tumorous masses in the pulmonary arteries were evaluated by dynamic contrast-enhanced MRI using T1- and T2-weighted SE images, GE images, as well as coronal 3D MRA in breath-hold technique. The percentage of tumor enhancement was determined by measuring regions of interest before and after Gd-DTPA administration on the 2D multiplanar spoiled GRE images. RESULTS: All four masses showed some contrast enhancement on the dynamically acquired GRE images. The degree of contrast enhancement correlated with the degree of tumor differentiation, content of myxoid matrix, and associated thrombus. Contrast-enhanced 3D MRA was useful for preoperative delineation of the peripheral pulmonary arteries to the subsegmental order. CONCLUSION: Dynamic contrast-enhanced 3D MRA of the pulmonary arteries can be used to delineate pulmonary arterial angiosarcomas preoperatively. Considerable variability of contrast agent uptake reflects the wide histologic behavior of these masses in differentiation from central pulmonary embolism.

Adult↗