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Biomedical subjects

F Nagy

Publications and source records attributed to F Nagy.

At least 163 records · Page 9Linked to original sources

Modulatory effects of a single neurons on the activity of the pyloric pattern generator in Crustacea.

The firing of a single neuron (named anterior pyloric modulator: APM) of the esophageal ganglion considerably modifies the pyloric rhythm of the rock lobster. These modifications, characterized by a long delay to onset and a long duration, include increased frequency and amplitude of oscillations of the motor neurons, changes in the efficacy of certain synapses within the network, and voltage-dependent modifications of membrane properties of some motor neurons. APM thus seems to be a true modulatory neuron. The APM-provoked changes resemble changes seen in the whole animal, making this a suitable system for an analysis of modulation on several levels.

Animals↗

Humanizing the student--cadaver encounter.

In a recently accredited medical school, the curriculum, which emphasizes the psychologic and social aspects of disease, includes innovative features aimed toward training students to provide humanistic health care in underserved areas. As part of this curriculum, an educational experiment was designed to explore issues concerning the medical student's first exposure to a cadaver. The authors describe the experiment as it evolved over a three-year period, and they discuss its value based on student evaluation and faculty opinion.

Anatomy↗

Response to cryptorchidism of the testis and epididymis of the opossum (Didelphis virginiana).

Adult male opossums, Didelphis virginiana, were rendered hemicryptorchid for 35 days. The cyrptorchid testis exhibited a significant reduction in weight, while the contralateral testis had a compensatory weight gain compared with testes of untreated animals. Histological changes in the cryptorchid testis included fibrosis of the tunica propria, involution of the seminiferous tubules and an apparent increase in the interstitial tissue. Many seminiferous tubules were empty and germinal cells were absent. Some Sertoli cells persisted, but the cytoplasm was vacuolated. Cryptorchid testes were characterized by mononuclear leucocytic invasion around the tubules, and some eosinophils were observed. Cryptorchidism in the opossum may induce a reaction similar to experimental orchitis.

Animals↗

Transient cycloheximide resistance in a tobacco cell line.

Cylcoheximide-resistant cell lines have been recovered from tissue cultures of haploid Nicotiana tabacum at the usual mutant frequency (10(-6)). One such line, CR 4/6 was studied in detail. Resistance is based on the potential of the callus to inactive cycloheximide. The transient nature of the resistance and its association with differentiated cells indicate that the new phenotype is not due to a mutation, but rather to an alteration in gene expression.

Cell Line↗

Cellular proliferation and renewal in the various zones of the hamster epididymis after colchicine administration.

Cellular proliferation was examined in the various regions of the excurrent ducts of the reproductive system of the male golden hamster after colchicine administration. Each of the two zones of the ductuli efferentes displayed only infrequent mitotic figures. Similarly, the basal cell population of the epididymis as well as the epithelium of the vas deferens exhibited too few mitotic figures to allow meaningful evaluation of cellular proliferation. The following observations were reported. 1. The principal cells of the entire epididymis are characterized by a singular diurnal cycle of proliferative activity reaching its maximum about 3 P.M. and its nadir about 9 A.M. 2. A circadian rhythm of cell division is also found in the principal cells of each of the six zones of the epididymis, although the time of maximal activity may vary from zone to zone. 3. The most actively proliferating region of the excurrent duct system is zone 3 of the epididymis, whereas the least active region is the ductuli efferentes. 4. The renewal rates of the principal cells vary considerably at various points along the excurrent duct system, ranging from cells which renew themselves as many as 10 times to cells which fail to renew themselves at all during the normal life-span of the animal.

Animals↗

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Greece↗