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Biomedical subjects

F Nagy

Publications and source records attributed to F Nagy.

At least 145 records · Page 8Linked to original sources
PubMed1985

A course in anatomy for emergency medicine residents.

The understanding of human anatomy is a critical component of the practice of medicine. A specialty with the breadth of emergency medicine is best approached with a sound basis in anatomy and pathophysiology which leads to a better understanding and differential diagnosis of the disease process. It was the authors' opinion that a specialty with the surgical emphasis found in emergency medicine should have a correlating emphasis in the anatomical sciences. Subsequent testing of PGY-II residents demonstrated a fair to poor understanding of anatomy when gauged by a standard freshman anatomy examination tailored to clinical circumstances. This paper reports on a 3-year experience in giving a 1-week 40-hour anatomy course which included didactic presentations by the anatomy and surgery departments. The impact of this course on clinical practice, problems in its preparation, and outcome of a shared experience with residents from general surgery are discussed. The course is felt to be a successful addition to the training of emergency medicine specialists.

Anatomy↗
PubMed1985

Clinical radiographs of the cadaver as a teaching aid in anatomy.

The use of clinical histories and radiographs of cadavers as a method for teaching anatomy was explored. This method was found to generate student interest in both anatomy and radiology, to make anatomy clinically relevant, and to supplement the laboratory manual by guiding the student through the dissection of medically or surgically complicated cases. It is an effective and workable method that is easily implemented and virtually cost free.

Anatomy↗
PubMed1985

Cadmium-induced alterations in the Siberian hamster epididymis.

The epididymis of sexually mature Siberian hamsters was found to consist of eight histologically distinct zones that were similar, in most respects, to those reported for other species. The notable exception to this is the presence of two types of tubules in zone 6; the typical major tubules predominate but are accompanied by smaller, contiguous, minor tubules. Following a single parenteral injection of cadmium chloride, the testes became necrotic and exhibited generalized sloughing of the seminiferous epithelium. The epididymis, on the other hand, retained their integrity following cadmium administration, although foci of degenerating cells were observed in the more proximal portions of the organ--i.e., zones 1-3. Vacular compromise is believed to be responsible for these necroses because of the severe edematous changes observed in the interstitial spaces. Evidence is presented for the localized degradation and elimination of necrotic cells from the testes as well as the epididymis.

Animals↗
PubMed1985

Annular pancreas.

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Adolescent↗
PubMed1983

Characterization and localization of alkaline phosphatase activity in rat testes.

Alkaline phosphatase activity in extracts of testes of sexually immature (13 days old) and sexually mature rats has been characterized by its heat sensitivity, the extent of inhibition by homoarginine and phenylalanine, and by polyacrylamide gel electrophoresis. The testicular enzyme appears to be a liver-bone-kidney-type alkaline phosphatase. There are no significant differences in the properties of the enzyme from animals of these two ages. Spermatocytes and early spermatids contain very little alkaline phosphatase activity; the specific activity of a nonflagellate germinal cell suspension is only 1/20th that of the whole testis. Since the constant level of activity in immature and mature animals is not consistent with the enzyme activity being present only in late spermatids, we conclude that the majority of the testicular enzyme is present in nongerminal cells. The presence of alkaline phosphatase in plasma membrane purified from testes of adult rats was demonstrated.

Alkaline Phosphatase↗
PubMed1983

Control of a central pattern generator by an identified modulatory interneurone in crustacea. I. Modulation of the pyloric motor output.

In the lobsters Fasus lalandii and Palinurus vulgaris, the rhythmical activity of the pyloric pattern generator of the stomatogastric nervous system is strongly modified by the firing of a single identified interneurone, whose activity we have recorded from the cell body, in vitro. The cell body of this interneurone, the anterior pyloric modulator (APM), is located in the oesophageal ganglion and sends two axons to the stomatogastric ganglion via the inferior oesophageal nerves, the commissural ganglia, the superior oesophageal nerves and the stomatogastric nerve. Firing of neurone APM modifies the activity of all the neurones of the pyloric network, including pacemaker and follower neurones. Its effects are both quantitative (increase in the frequency of the rhythm and in the frequency of spikes within cell bursts) and qualitative (modifications in relative efficacies of the synaptic relationships within the pyloric network, which in turn lead to changes in the phase relationships between the discharges of the neurones). The effects on pyloric activity induced by firing of neurone APM are established slowly (one or two seconds) and are of long duration (ten times the duration of APM's discharge). These modifications most probably involve muscarinic cholinergic receptors. APM's influences on the activity of pyloric neurones appear to be characteristic of a neuromodulatory process and are such that they may be of behavioural significance in the intact animal.

Animals↗
PubMed1983

Control of a central pattern generator by an identified modulatory interneurone in crustacea. II. Induction and modification of plateau properties in pyloric neurones.

In the isolated stomatogastric nervous system of the lobster Fasus lalandii, the strong modifications of the pyloric motor pattern induced by firing of the single anterior pyloric modulator neurone (APM) are due primarily to modulation by APM activity of the regenerative membrane properties which are responsible for the 'burstiness' of all the pyloric neurones and particularly of the non-pacemaker neurones (constrictor motoneurones). This modulation has been studied under experimental conditions where the main extrinsic influences usually received by the pyloric constrictor neurones (intra-network synaptic interactions, activity of pacemaker neurones, and phasic central inputs from two premotor centres) are minimal. Under these conditions a brief discharge of neurone APM induces long plateaus of firing in all of the pyloric neurones. The non-pacemaker neurones of the pyloric network are not simply passive follower neurones, but can produce regenerative depolarizations (plateau potentials) during which the neurones fire spikes. The ability of the pyloric constrictor neurones to produce plateau potentials (plateau properties) contributes greatly to the generation of the rhythmical pyloric motor pattern. When these neurones spontaneously express their plateau properties, firing of neurone APM amplifies these properties. When most of the central inputs usually received by the pyloric constrictor neurones are experimentally suppressed, these neurones can no longer produce plateau potentials. In such conditions, firing of the single modulatory neurone APM can reinduce plateau properties of the pyloric constrictor neurones. In addition, firing in APM neurone slows down the active repolarization phase which terminates the plateau potentials of pyloric constrictor neurones. This effect is long-lasting and voltage-dependent. Modulation by APM of the plateau properties of the pyloric neurones also changes the sensitivity of these neurones to synaptic inputs. This effect can explain the strong modifications that an APM discharge exerts on a current pyloric motor pattern. Moreover, it might render the motoneurones of the pyloric pattern generator more sensitive to inputs from a command oscillator, and contribute to switching on the pyloric motor pattern.

Animals↗
PubMed1982

Spatial mapping, working memory, and the fimbria-fornix system.

Rats with lesions severing either the subcallosal fornix (Fo) or the medial half of the fimbria (Fi) were used. They were compared with control (Co) animals in a working memory task (serial alternation) and a reference memory task (cue-guided alternation). Neither task required spatial mapping strategy. Damaging the Fi, but not the Fo, caused a severe deficit in the serial alternation task. Analysis of individual performance revealed that Fi rats either adopted a "side strategy, " resulting in worse than chance performance. This active perseveration required intact working memory mechanism. In the cue-guided alternation task, Fo animals proved superior to Co and Fi rats. These findings are inconsistent with notions that the exclusive role of the hippocampus is spatial mapping or storing of recent memories. They indicate also differential involvement of the fimbria and fornix fibers in behavior.

Animals↗
PubMed1982

Structural features of a specialized region of the epididymis of the Siberian hamster (Phodopus sungorus).

Light and electron microscopic observations of zone six of the Siberian hamster (Phodopus sungorus) epididymis reveal that two distinct tubule populations exist in this region. The population of smaller tubules apparently arises as diverticula of the larger ducts but, though contiguous, the contents of each remain different and separate. While the larger tubules are laden with sperm and seminal fluid, the smaller ones area filled with degenerating cells and cellular debris. Cytologically, the features of the two tubule types are similar. Both display a prominent Golgi apparatus, substantial amounts of rough endoplasmic reticulum, an extensive population of various lysosomal forms and scattered crystalline inclusions.

Animals↗