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Biomedical subjects

F Matsubara

Publications and source records attributed to F Matsubara.

At least 181 records · Page 10Linked to original sources
PubMed1983

[Eosinophilic cystitis: a report of 2 cases].

Two patients with eosinophilic cystitis are presented in this report. The first case was a 39-year-old man who was admitted to our clinic with complaints of pollakisuria, pain on urination and hematuria for a month, which had not been relieved by antibiotic therapy. He had both a family and a personal past history of allergy. Excretory urograms showed a mild bilateral hydroureter and small bladder with irregular filling defects. Cystoscopic examination revealed velvety, ulcerated areas in the bladder mucosa, and we diagnosed these changes as eosinophilic cystitis after bladder biopsy. Steroid and antihistaminic therapy improved these symptoms. The second case was a 67-year-old woman who visited our clinic complaining chiefly of hematuria for 2 months. There was no predisposition to allergy, but she had a past history of uterine cancer which had been treated with irradiation. Cystoscopic examination disclosed a large amount of intravesical coagula, and erythematous and edematous areas with petechiae of the bladder mucosa. Bladder biopsy revealed hemangioma and eosinophilic cystitis. There was no recurrence of cystitis after the removal of the coagula without any other treatment.

Adult↗
PubMed1982

Localization of adenylate cyclase and 5'-nucleotidase activities in human thyroid follicular cells.

The localization of adenylate cyclase and 5'-nucleotidase activities in the follicular cells of adenomatous goiter and normal thyroid was studied by light and electron microscopy. Simultaneous biochemical measurement for both activities was carried out to confirm the histochemical findings. Adenylyl-imidodiphosphate (AMP-PNP) was used as an effective substrate for adenylate cyclase. The specificity of the adenylate cyclase reaction was also examined by adding oxalacetic acid or PCMB as an adenylate cyclase inhibitor, and by adding sodium fluoride or TSH as an adenylate cyclase stimulator to the reaction mixture. In the case of tissue from adenomatous goiter, a large amount of the reaction product of the adenylate cyclase activity was found uniformly in the apical and lateral plasma membrane and not in the basal plasma membrane. In the cases of normal thyroid, a small amount of the reaction product of adenylate cyclase activity was demonstrated, and only in the lateral plasma membrane of the follicular cells. On the otherhand, the histochemical localization of 5'-nucleotidase activity was the same in adenomatous goiter and normal thyroid. The reaction product of 5'-nucleotidase activity was found predominantly in the apical plasma membrane of the follicular cells. The biochemical findings indicated that the activity of adenylate cyclase per gram tissue was approximately 2 times higher in the case of adenomatous goiter than that in the case of normal thyroid, while the 5'-nucleotidase activity in adenomatous goiter was in slightly higher level than in normal thyroid. Thus the histochemically demonstrable amount of adenylate cyclase and 5'-nucleotidase reflected the activity levels measured biochemically. The lack of demonstrable adenylate cyclase activity in the basal plasma membrane suggests the possibility that this structure may not play any important role in TSH reception.

5'-Nucleotidase↗
PubMed1982

Cytoplasmic blood plasma inclusions in human hepatocytes.

Hepatocellular blood plasma inclusions were demonstrated in conventional formalin-fixed paraffin-embedded liver tissue by the immunoperoxidase technique in 114 out of 197 liver specimens. They were usually round or elliptical in shape, their size varying from a few microns to about 30 microns in diameter. Albumin, fibrinogen, alpha 1-antitrypsin, IgG, IgM, IgA, ceruloplasmin and transferrin were demonstrated in the inclusions, in that order of frequency. A majority were negative with the periodic acid Schiff stain after amylase digestion, but a few were positive. Many of them seemed to correspond to vacuoles in the hepatocytes but some were not seen in HE-stained sections. The inclusions were frequently seen in autopsy liver specimens, but were rare in surgical ones. Most of the inclusions might develop at an agonal stage, probably as a result of hypoxia or circulatory disturbances in the livers.

Adult↗
PubMed1982

Caroli's disease in congenital hepatic fibrosis and infantile polycystic disease.

Two of three patients with infantile polycystic disease and all three patients with congenital hepatic fibrosis revealed multiple gross cystic dilatation of the intrahepatic biliary tree, referred to as Caroli's disease. All three patients with congenital hepatic fibrosis showed recurrent cholangitis related to coexisting Caroli's disease, and two of them died of sepsis following cholangitis. There were several common morphologic findings in the intrahepatic biliary tree of macroscopic and microscopic levels in infantile polycystic disease and congenital hepatic fibrosis with Caroli's disease: 1. irregular, non-obstructive dilatation of the duct lumen; 2. bulbar protrusion of the duct wall into the lumen; and 3. bridge formation of the duct wall across the lumen. These ductal changes might be caused by a combination of uneven and disproportionate overgrowth of biliary epithelia and their supporting connective tissue. This pathogenetic mechanism might be operative along the entire intrahepatic biliary system in this disease group, and involvement of the smaller levels in early life might result in infantile polycystic disease and congenital hepatic fibrosis and simultaneous or possibly later involvement of the larger levels in Caroli's disease.

Adult↗
PubMed1982

Black thyroid. Morphological, biochemical and geriatric studies on the brown granules in the thyroid follicular cells.

An autopsy case of a 73-year-old man with "black thyroid" was reported. Investigations by light and electron microscopy and histochemical study of the black thyroid material disclosed the massive deposition brown granules in the follicular cells, to be residual bodies containing lipids. Lipids in these granules were mainly composed of phospholipid by biochemical analysis. Concerning the thyroidal function of this case the value of T4-I in the serum was within normal range (4.8-7.5 micrograms/dl) and peroxidase, NADPH-cytochrome C reductase and acid phosphatase activity in the black thyroid material revealed no significant increase or decrease, compared with other 12 autopsied cases. These granules resembled so-called lipofuscin granules, and the frequency and grade of the deposition in autopsied cases increase with aging.

Acid Phosphatase↗
PubMed1981

Umbilical core-out operation for a completely patent vitelline duct.

An umbilical core-out operation for a completely patent vitelline duct in a premature baby with successful preoperative manual reduction of the prolapsed ileal loops is described. In certain cases with this rare anomaly this procedure can be applied. The procedure is easy, timesaving, bloodless and necessitates no laparotomy incision.

Humans↗
PubMed1981

Pseudomonas pickettii bacteremia.

A case of bacteremia caused by Pseudomonas pickettii is reported. This represents the first case of infection due to this species.

Anti-Bacterial Agents↗
PubMed1981

Myasthenia gravis: relation between jitter in single-fiber EMG and antibody to acetylcholine receptor.

In 39 patients with myasthenia gravis, we measured jitter in the extensor digitorum communis muscle, using single-fiber electrode (SFEMG) and the serum titer of antiacetylcholine receptor antibody. Clinical severity was correlated more closely with jitter, especially the percentage of abnormal jitter pairs with blocking than with antibody titer. In patients who responded fairly well clinically after certain treatments, both the SFEMG abnormalities and antibody titer tended to improve in parallel with clinical improvement. After the plasma exchange, there was a time lag between the recovery from the defective neuromuscular transmission and the rapid decrease in antibody titer. The percentage of abnormal jitter pairs with blocking and the mean jitter value reflect defective neuromuscular transmission in generalized myasthenia gravis.

Adolescent↗