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Biomedical subjects

F Kokot

Publications and source records attributed to F Kokot.

At least 217 records · Page 12Linked to original sources
PubMed1990

Plasma level of atrial natriuretic peptide in renal venous blood--marker of kidney ischemia?

In 12 patients with unilateral significant renal ischemia plasma levels of atrial natriuretic peptide (ANP) were estimated in renal vein blood of the ischemic (IK) and contralateral kidney (NK) and in arterial blood under supine and upright conditions. Plasma ANP levels in renal vein blood were compared with plasma renin activity (PRA) of the same blood samples. Plasma ANP levels in renal vein blood of the contralateral kidney (87 +/- 9 pg/ml) were significantly lower than in arterial blood (131 +/- 11 pg/ml) and renal vein blood of the ischemic kidney (139 +/- 16 pg/ml). In contrast plasma ANP concentrations in renal vein blood of the ischemic kidney were slightly or markedly higher than in arterial blood. A positive correlation was found between the ratio of plasma ANP in renal vein blood of the IK to that of the NK under supine condition and the respective ratio of PRA. Data presented in this paper suggest the presence of abnormal handling of ANP by an ischemic kidney and that plasma ANP levels in renal vein blood may be a marker of renal ischemia.

Adolescent↗
PubMed1990

[Effect of water immersion on glucose, insulin and atrial natriuretic factor levels in patients with transplanted heart].

In 6 heart transplant patients [HTP] and in 10 healthy subjects the influence of water immersion [WI] on blood levels of glucose, insulin and atrial natriuretic peptide [ANP] were studied. HTP showed significantly higher baseline ANP levels and a reduced response of ANP to water immersion as compared with normals. HTP did not differ from normals by baseline plasma levels of glucose and insulin. WI induced significant decline of blood glucose and increase of insulin in both examined groups. A significant correlation was found between WI induced increase of blood insulin and ANP and between the increase of ANP and decline of blood glucose both in HTP and in healthy subjects. Data presented in this paper suggest existence of a significant relationship between ANP and insulin secretion and participation of ANP in the carbohydrate metabolism both in normals and HTP.

Adult↗
PubMed1990

Influence of erythropoietin treatment on function of the pituitary-adrenal axis and somatotropin secretion in hemodialyzed patients.

In five hemodialyzed patients the influence of erythropoietin (EPO) treatment for 3 months on function of the pituitary-adrenal feedback and STH secretion was studied. Results were compared with those obtained in 6 hemodialyzed patients (No-EPO group) showing a comparable Hb concentration and Hct value as patients in the EPO group post-treatment and in 15 healthy subjects. EPO treatment was followed by a significant (ACTH and STH) or moderate (cortisol) suppression of basal plasma levels of ACTH, STH and cortisol respectively, and by a significant reduction of the response of plasma concentrations of these hormones to insulin-induced hypoglycemia. As the response of plasma levels of ACTH, STH and cortisol respectively in patients of the EPO group post-treatment differed markedly from that of the No-EPO group with similar Hb and Hct values, it seems that the EPO-induced endocrine alterations are not, at least not exclusively, a consequence of the improvement of anemia. Results presented in this study suggest that EPO treatment influences directly or indirectly the function of endocrine organs.

Adrenocorticotropic Hormone↗
PubMed1990

[Selected parameters of calcium and phosphate metabolism in patients after kidney transplantation and administration of azathioprine or cyclosporin A].

The influence was studied of the type of immunosuppression on calciuria, phosphaturia, and on the levels of parathyroid hormone (PTH), calcitonin (CT), 25-hydroxycholecalciferol (25/OH/D), total calcium, magnesium, and alkaline phosphatase activity in 24 patients after renal transplantation. Twelve of these patients received cyclosporin with prednisone (group CyA) and other 12 were treated with azathioprine and prednisone (group Aza). Independently of the type of immunosuppression used, in both groups a significantly higher concentration of PTH, CT, 25/OH/D and greater activity of alkaline phosphatase were demonstrated in relation to healthy controls. In both studied groups the patients had also a significantly reduced calciuria and phosphatemia than controls. In group Aza the patients had a significantly lower phosphaturia and significantly higher magnesemia than in group CyA. The results of these investigations suggest a certain influence of the type of immunosuppression on the intensity of calcium-phosphate metabolism in renal graft recipients.

Adult↗
PubMed1990

[Effect of adrenergic beta receptor blockaders and thiazide diuretics on gastric acid and gastrin secretion in patients with essential hypertension].

The purpose of the study was to evaluate the effect of 6 weeks treatment with hydrochlorothiazide or propranolol on gastric acid and gastrin secretion in essential hypertension. The study was carried out in 10 patients receiving propranolol and 10 treated with hydrochlorothiazide. Acid and gastrin secretion were determined during histamine stimulation tests (Kay's test). Before the treatment the patients with essential hypertension were not significantly different from healthy controls with respect to acid secretion and gastrinemia profile after histamine stimulus. In both groups of patients no significant effect was observed of hypotensive treatment on basal acid output, but a significant inhibitory effect on gastrin secretion was noted. This effect was significantly greater in patients treated with propranolol than in the hydrochlorothiazide group. Moreover, in propranolol-treated patients a significant fall of histamine-induced acid secretion was found.

Adult↗
PubMed1990

Cimetidine pharmacokinetics after oral administration of cimetidine retard in normal and impaired renal function.

Cimetidine pharmacokinetics was investigated in four groups: Group I with three normals (serum creatinine less than 1.5 mg/dl), Group II with three kidney patients, renal function slightly impaired (serum creatinine greater than 1.8-4.3 mg/dl), Group III with three patients suffering from severe impairment (serum creatinine greater than 4.3 mg/dl) and Group IV with three patients on chronic hemodialysis. All four groups were given cimetidine retard (350 mg tablets Neutronorm retard, Ebewe Arzneimittel GmbH, A-4866 Unterach a.A., Austria). Groups I and II (normals and slightly impaired renal function) received the tablets twice a day with an interval of 12 h (7:00 a.m. and 7:00 p.m.). Groups III and IV (severely impaired renal function and hemodialysis patient were only given one dose a day (7:00 a.m.). The group of normals (I) and the group with slightly impaired renal function (II) had the highest serum cimetidine concentrations one to two h after the morning dose, followed by an exponential decrease. After the evening dose in Group I, the highest concentrations were found after 4 h. Group II had the highest concentrations four to eight h after administration. Compared to the morning dose, the exponential decrease of the serum cimetidine concentration was delayed in onset and slower in phasing out. Furthermore, concentration was higher during the night than during the day.(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Oral↗
PubMed1989

[Effect of long term dialysis therapy on blood prolactin patients with chronic renal failure].

An effect of dialysis therapy on baseline prolactinemia and prolactinemia following suppression test with alpha-bromocriptine was determined in 34 patients with chronic renal failure. Gradual decrease in hyperprolactinemia with the duration of dialysis therapy has been observed. Prolactinemia baseline values in patients dialysed for 100 months did not differ from those determined in healthy individuals.

Adult↗
PubMed1989

Endocrine abnormalities in patients with endstage renal failure.

Data presented in this study suggest existence of hyperendorphinism in uraemic patients. This hyperendorphinism may be regarded both as a primary beneficial compensatory mechanism counteracting disturbances of the internal environment, while causing secondary harmful side effects, which contribute to the uraemic state. Erythropoietin treatment of uraemic, haemodialyzed patients is followed by marked endocrine alterations (suppression of plasma levels of STH, ACTH, prolactin, glucagon, aldosterone, cortisol and plasma renin activity, elevation of plasma insulin and atrial natriuretic levels, lack of influence on plasma PTH, CT and AVP). It remains to be clarified whether the erythropoietin induced endocrine alterations are due to correction of the existing anaemia or reflect a specific effect of this hormone.

Endocrine System Diseases↗
PubMed1989

Does the kind of immunosuppressive therapy influence plasma renin activity, aldosterone and vasopressin in patients with a kidney transplant?

In 24 patients with a functioning kidney transplant and in 33 healthy subjects plasma renin activity (PRA), plasma aldosterone and vasopressin (AVP) levels were assessed under basal conditions and after dietary sodium restriction. Twelve patients were treated with azathioprine and another 12 with cyclosporine A. From the results obtained it seems that immunosuppressive drugs used in transplanted patients ar involved in the pathogenesis of endocrine abnormalities and that the kind of immunosuppressive therapy is of minor importance in their development of maintenance. Transplanted kidneys show a preserved reaction pattern of renin secretion to sodium deprivation and upright position.

Adult↗
PubMed1989

Water immersion induced alterations of atrial natriuretic peptide in patients with non-inflammatory acute renal failure.

Water immersion induced alterations of plasma atrial natriuretic peptide (ANP), circulating plasma volume (PV), plasma sodium and potassium and mean blood pressure (MAP) were examined in 12 patients with non-inflammatory acute renal failure (ARF) and in 15 healthy subjects. In patients with ARF a significantly elevated basal ANP (139 +/- 13 pg/ml versus 75 +/- 4 pg/ml in normals) and elevated MAP (112 +/- 3.5 mmHg versus 87 +/- 2 mmHg in normals) were found. Water immersion induced a significant increase in plasma ANP in both groups, which was significantly more marked in healthy subjects (152 +/- 13 pg/ml) than in patients with ARF (86 +/- 13 pg/ml). Water immersion was accompanied by a significantly more marked reduction of MAP (23 +/- 3 mmHg) and plasma sodium (6.1 +/- 0.6 mmol/l) in patients with ARF than in normals (12.7 +/- 1.5 mmHg and 4.2 +/- 0.1 mmol/l respectively). In contrast to healthy subjects, in patients with ARF water immersion did not induce enhanced diuresis. In patients with ARF a significantly more marked increase in plasma volume was found than in normals. Data obtained in this study seem to prove preservation of the physiological regulatory mechanism of ANP secretion in ARF patients but reduction of ANP release induced by central volume expansion. The importance of elevated basal plasma values in the maintenance of ARF has not been proven.

Acute Kidney Injury↗
PubMed1989

Influence of type of immunosuppressive therapy on secretion of somatotropin and function of the pituitary-adrenal and pituitary-gonadal axis in patients with a kidney transplant.

In 24 patients with a functioning kidney transplant, hypoglycemia-induced somatotropin (STH), adreno-corticotropin and cortisol secretion was studied. In a further 24 transplanted patients, secretion of lutropin, follitropin and testosterone after the intravenous administration of luliberin was assessed. Data obtained in this paper suggest the presence of abnormal function of the pituitary-adrenal and pituitary-gonadal axis and abnormal STH secretion in patients with a functioning transplant. Type and duration of immunosuppressive therapy seem to influence the intensity of the above-mentioned endocrine abnormalities.

Adult↗
PubMed1989

[Effect of hemodialysis on the functional status of small airways and partial pressure of oxygen and carbon dioxide in the blood of patients with chronic uremia].

In 18 patients with chronic uremia the effect of 4 hour hemodialysis on VC, FEV1, PEF, MEF25, MEF50, MEF75, PaO2 and PaCO2 were analysed. Significant falls in PaO2 and PaCO2 were found after ending the four hour long hemodialysis. Only nonsignificant changes in the other parameters were observed. The results of this study demonstrates the role of ventilatory disturbances of small airways in the pathogenesis of dialysis induced hypocapnia and hypoxemia.

Adult↗