Search PubMed⌕ Search

Biomedical subjects

F Jung

Publications and source records attributed to F Jung.

At least 199 records · Page 11Linked to original sources
PubMed1986

[Predictor function of hemorheologic parameters with reference to the incidence of manifest circulatory disorders: Concept of the Aachen study].

The prevention of cardiovascular disease has up till now generally been limited to control of the classical risk factors. The primary problem of the risk factor model is, that although a statistically verified relationship exists between risk factors and vascular disease, an individual prognosis is presently impossible. Surveys that show a relation between risk factors and impaired blood fluidity support the conception that a change in blood fluidity could be considered an early detection screening of vascular diseases. Prospective studies have shown that the hematocrit is related to circulatory disturbances. The main aim of the present study was to determine the clinical relevance of rheological parameters (hematocrit, plasma viscosity, erythrocyte rigidity, thrombocyte aggregation, erythrocyte aggregation), and the importance of altered blood fluidity as a predictor of manifest cerebral, cardiac or peripheral vascular disturbance.

Blood Viscosity↗
PubMed1986

Do different ischemic brain lesions have different hemorheological profiles?

The following hemorheological parameters were determined in 68 patients with ischemic brain lesions and in 28 controls: yield shear stress, erythrocyte aggregation, erythrocyte rigidity, plasma viscosity, and hematocrit. The patients were classified into various groups on the basis of etiological criteria. The results revealed differences between certain hemorheological variables (erythrocyte aggregation, plasma viscosity) in some of the stroke groups. Plasma viscosity was significantly higher in patients with Binswanger's disease and significantly lower in the control group compared with values measured in patients with macroangiopathy and microangiopathy. Erythrocyte aggregation was significantly lower in the controls than in the other groups. Discriminant analysis revealed that plasma viscosity, erythrocyte aggregation and hematocrit were the most useful variables for classification.

Adult↗
PubMed1986

[Determination of reference ranges of rheologic parameters: study of 653 randomly selected probands of the Aachen district].

To determine reference ranges for rheologic parameters (hematocrit, plasma viscosity, erythrocyte aggregation, erythrocyte rigidity) a randomized study involving 653 subjects was carried out. Conditions of sampling, transportation and storing of blood specimens were established prior to the survey. Only 283 subjects met the criteria for enrollment in the study; the others were rejected because of inconspicuous history, normal findings in physical and Doppler-sonographic examination and absence of the risk factors hypertension, diabetes mellitus, overweight, rheumatic diseases, and smoking. The reference range for hematocrit was determined by an impedance-measuring device to equal 39-52% for males and 34-50% for females. The reference range for plasma viscosity, measured by a capillary-tube-plasma viscometer, was found to vary from 1.14 mPas to 1.34 mPas. The reference values for the standardized erythrocyte aggregation index was determined with the mini erythrocyte aggregometer to range from 8 to 21. Erythrocytes measured with the selecting-erythrocyte rigidometer showed a rigidity reference range between 0.83 and 1.19. Analysis of the results revealed that the parameters were independent of age (except in young children) and sex (with the exception of hematocrit).

Age Factors↗
PubMed1986

[Comparative study of low molecular dextran or hydroxyethyl starch as a volume substitute in hemodilution therapy].

Rheological therapy, as an immediate treatment in conjunction with physical therapy and the removal of risk factors, plays a significant role in the management of patients with peripheral vascular disease experiencing reduced walking tolerance. An essential element of rheological therapy is hemodilution. Currently, is still uncertain which plasma substitute solution would be the most appropriate in such cases. This study compared the effectiveness of low molecular hydroxyethyl starch to low molecular dextran during a 16-day hemodilution in combination to physical therapy. The clinical improvement observed with both plasma substitute solutions was comparable, yet in view of the cardiac volume overload, dextran demonstrates greater circulatory stress due to the transient pressure increase and more side effects. For this reason, we prefer to administer low or middle molecular hydroxyethyl starch in the dilution treatment of peripheral arterial occlusive disease as a chronic degenerative vascular disease.

Adult↗
PubMed1986

[Autotransplantation of the spleen. A new possibility in the conservative surgery of the spleen].

Conservative surgery to spleen is an ancient concept brought up-to date by improved knowledge of its fundamental roles in immunity and anti-bacterial defences. Suture of spleen and partial splenectomy ensure the best possible functional results but have technical limitations resulting frequently in splenectomy to provide hemostasis. Data from clinical and experimental studies and reports in the literature have demonstrated that autotransplantation of spleen is a simple, safe and effective method for preventing the true dangers of asplenia. Optimal results from autotransplantation of spleen are obtained when the injured organ is broken into small fragments which are then implanted into small spaces fashioned in the greater omentum. Clinical and biological tests to evaluate functional value of these transplants have shown that results approach those of a normal or sutured spleen. It is concluded that this procedure, which completes other conservative methods of splenic surgery, should definitely exclude hemostasis splenectomy from therapy of injuries to spleen.

Animals↗
PubMed1984

[Middle-molecular hydroxyethyl starch as a volume substitute. Its rheological effect in peripheral arterial occlusive diseases].

The tolerance to and effectiveness of middle-molecular hydroxy-ethyl starch as volume replacement by isovolemic haemodilution over 6 weeks was tested in 15 patients with peripheral arterial obstructive disease, stages II and III. After 6 weeks of isovolemic haemodilution treatment the pain-free walking distance increased significantly, the peak-flow after reactive hyperaemia increased, blood pressure and pulse remained unchanged, blood fluidity was significantly improved. This pilot study indicates that middle-molecular hydroxy-ethyl starch as volume replacement through isovolemic haemodilution represents a good alternative to dextran. It may even be superior to dextran in the treatment of arterial obstructive disease.

Arterial Occlusive Diseases↗
PubMed1984

[Hemorheologic therapy in peripheral arterial occlusive disease].

In view of current knowledge drug treatment of peripheral arterial occlusive disease is required at stage IIb in most cases. Angiological diagnostic procedures should be conducted to determine the location and extent of occlusion as well as to evaluate the blood fluidity. Rheological therapy is indicated in cases of microangiopathy, inoperable macroangiopathy, pre- and postoperative treatment of macroangiopathy and macroangiopathy after angioplasty or fibrinolysis. Drug treatment is administered according to clinical status and rheological parameters. The main emphasis in therapy includes hemodilution, reducing the fibrinogen concentration and improvement of blood fluidity. The findings of hemodilution therapy with various hydroxy-ethyl starches as well as a monotherapy with naftidrofuryl are presented and discussed.

Adult↗
PubMed1984

Assignment of hemorheological instruments in the angiologic ambulance: first results and experiences.

Patients with chronic arterial disorders (CAD) frequently exhibit rheological alterations of the blood beneath generalisated sclerosing of the vessels and restricted arterial diameters. Alterations of different rheological parameters were determined in more than 80% of the examined patients. The following parameters were measured: yield shear stress in the ESM, hematocrit level in the IHA, plasma viscosity in the CTPV, standardized erythrocyte aggregation index in the MEA and standardized erythrocyte rigidity index in the SER.

Adult↗