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Biomedical subjects

F Denis

Publications and source records attributed to F Denis.

At least 253 records · Page 14Linked to original sources

Spinal instability as defined by the three-column spine concept in acute spinal trauma.

This article is a presentation of the concept of the three-column spine. The concept evolved from a retrospective review of 412 thoracolumbar spine injuries and observations on spinal instability. The posterior column consists of what Holdsworth described as the posterior ligamentous complex. The middle column includes the posterior longitudinal ligament, posterior annulus fibrosus, and posterior wall of the vertebral body. The anterior column consists of the anterior vertebral body, anterior annulus fibrosus, and anterior longitudinal ligament. Major spinal injuries are classified into four different categories, all definable in terms of the degree of involvement of each of the three columns. Each type is defined also in terms of its pathomechanics, roentgenograms, and computerized axial tomograms, as well as in terms of its particular stability. The compression fracture is basically stress failure of the anterior column with an intact middle column. The burst fracture indicates failure under compression of both the anterior and middle columns. The seat-belt-type spinal fracture is the result of failure of the posterior and middle columns under tension with an intact anterior hinge. In fracture-dislocations, the structure of all three columns fails from forces acting to various degrees from one or another direction.

Biomechanical Phenomena↗

Lack of anti-HBc IgM in neonates with HBsAg carrier mothers argues against transplacental transmission of hepatitis B virus infection.

Transplacental transmission of hepatitis B virus infection was studied in 51 Senegalese neonates born to mothers who were chronic carriers of HBsAg. 13 mothers were positive for both HBsAg and HBeAg. Mother-to-infant transmission of these two markers was different with 3 children being HBsAg positive and HBeAg negative at birth and 6 being HBsAg negative but HBeAg positive. At birth none of the 51 children had anti-HBc IgM detected by a highly specific enzyme immunoassay, indicating that none had had a primary immune response in utero to HBV infection. These HBV serum markers in newborn infants indicate contamination by maternal blood at delivery rather than active infection in utero. Prophylaxis at birth is advisable in children of mothers who are chronic carriers.

Adolescent↗

Hepatitis B vaccine: further studies in children with previously acquired hepatitis B surface antigenemia.

Three doses of inactivated hepatitis B vaccine were given at 1-month intervals to 31 hepatitis B surface antigen (HBsAg)-positive Senegalese children aged between 3 and 24 months. A control group of 18 HBsAg-positive Senegalese children received diphtheria-tetanus-polio vaccine. Immunization of HBsAg-positive infants with hepatitis B vaccine was safe but inefficient. After a 12-month follow-up, the prevalence of HBsAg chronic carriers was not significantly reduced in the hepatitis B vaccine group as compared with the control group: 48.4 and 66.7%, respectively. The presence of hepatitis B antigen was found to be a major risk factor for HBsAg-positive children to develop a chronic carrier state. The risk of developing an HBsAg chronic carrier state was also related to advancing age at time of enrollment in the study.

Carrier State↗

[Epidemiology and prognosis of Haemophilus influenzae meningitis in Africa (901 cases)].

Haemophilus influenzae meningitis are frequent in Africa in infants between 6 months and two years of age. Type b is observed in 97% of cases. In Dakar, 2% of strains are resistant to ampicillin and 0% to chloramphenicol. Lethality is about 30% and sequellae are very frequent. Prognosis can be predicted by a cotation scale including consciousness, tonus, seizures, nutritional status, delay before treatment and initial bacterial antigen level in CSF.

Child, Preschool↗

[Latex agglutination test and counterimmunoelectrophoresis in the diagnosis of Haemophilus influenzae meningitis].

Authors have searched for Haemophilus influenzae by culture and by detection of capsular antigens in CSF of 1.700 bacterial meningitis in Dakar. Culture has been positive in 71.9%, counter-immunoelectrophoresis in 94.9% and latex (slidex meningitis kit) in 91.2% of cases. Diagnosis results are improved of 39% comparatively with bacteriologic culture. False positive results caused by antigenic cross-reactions have been observed only in 1.3% of others bacterial meningitis. Latex-test is allowing a diagnosis in three minutes and a quantitative determination of antigens (useful for pronostic).

Counterimmunoelectrophoresis↗

[Spinal concentrations of amoxicillin in purulent meningitis in children].

Hundred and fifteen children suffering of purulent meningitis (S.pneumoniae: 19; H.influenzae: 44; N.meningitidis; 23; others: 29) were treated by amoxicillin 200 mg/kg/day in four intramuscular injections. Spinal taps for assay of antibiotic levels in the CSF were taken 1 or 3 or 6 hours after the injection. The levels were respectively for this samples of 6.9 -1.7-1.4 micrograms/ml during the first 48 hours of treatment and 4.4-1.7-1.9 after one week. The concentrations CSF/serum were from 5 to 9.8 per cent at the beginning of treatment.

Amoxicillin↗

Unilateral external fixation for severe open tibial fractures. Preliminary report of a prospective study.

In a prospective survey of severe open tibial fractures, the incidence of serious complications with relatively rigid one- or two-plane unilateral fixator frames was considerably lower than with internal fixation by plates and screws. Unilateral configurations that contain rigid components provide better wound access than bilateral frames and interfere less with knee and ankle motion; they allow unencumbered partial and even full weight-bearing. This increases comfort and mobility and may have a positive effect on fracture healing. No standard formula exists, however, for the application of an optimal unilateral frame. The clinical and mechanical demands of each patient and injury must be considered individually.

Adolescent↗