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Biomedical subjects

F C Blodi

Publications and source records attributed to F C Blodi.

At least 37 records · Page 2Linked to original sources
PubMed1985

The role of orbital exenteration in choroidal melanoma with extrascleral extension.

The management of choroidal melanoma with extrascleral extension has been a subject of controversy with some proposing orbital exenteration whenever extrascleral extension is demonstrated and others feeling it to be of no value in increasing survival. We reviewed the cases of 43 patients with extrascleral extension of choroidal melanoma. Although five-year survival had previously been demonstrated to be significantly improved in patients undergoing early orbital exenteration at our institution, extended follow-up in 16 consecutive cases revealed ultimate tumor related mortality to approach that of patients refusing exenteration. Only in cases with nonencapsulated or surgically transected extension did exenteration appear to improve survival. In ten cases with delayed recurrence of tumor in the orbit, exenteration proved to be palliative rather than curative.

Aged↗
PubMed1984

Dual properties of cultured retinoblastoma cells: immunohistochemical characterization of neuronal and glial markers.

The dual properties of two human retinoblastoma cell lines, WERI-Rb1 and Y79, were investigated with immunohistochemistry. Two neuron-specific markers, dopamine-B-hydroxylase (DBH) and tetanus toxin, and an astrocyte-specific marker, the glial fibrillary acid protein (GFAP), were applied for immunohistochemical reactions. With peroxidase-antiperoxidase (PAP) and immunofluorescence techniques, all of the WERI-Rb1 and Y79 cells showed consistently positive results with both neuronal and glial markers. The findings demonstrate that cultured retinoblastoma cells WERI-Rb1 and Y79 have both neuronal and glial properties.

Cell Line↗
PubMed1983

[Calcinosis of the eyelid].

Subepidermal calcified nodules are a well known clinical and histologic entity. Their occurrence in the lids should be recognized. Their origin remains obscure. All of the authors' patients were under 21 years old and had had the lesion for a number of years. The calcinosis must be a lesion which is acquired in early life and grows slowly for a few years. It does not cause any clinical symptoms. Histologically, the lesion consists of calcium deposits which are only rarely surrounded by an inflammatory (granulomatous) reaction.

Adolescent↗
PubMed1982

Unilateral optic nerve head and choroidal metastases from a bronchial carcinoma.

A 61-year-old man presented with uniocular gradually progressive visual loss, pain in the eye, visual activity of 6/60, markedly constricted visual fields, optic disc edema, retinal pigment epithelial disturbance at the posterior pole, and markedly delayed filling of the choroid on angiography, with a normal fellow eye. He had suffered from recurrent seizures for 15 years, with some evidence of cortical demyelination. Erythrocyte sedimentation rate was elevated. About 5 months after the onset of visual disturbance, evidence of bronchial carcinoma became apparent and he died 6 weeks later. The etiology of his ocular lesions was established only by histopathological evidence of metastases into the optic nerve head and the choroid. Diagnostic problems presented by the ocular findings are discussed.

Carcinoma, Bronchogenic↗