William R. Wilde (1815-1876) in Vienna.
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Biomedical subjects
Publications and source records attributed to F C Blodi.
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German-speaking immigrants came to America at the end of the seventeenth century from Central Europe, in the 19th century predominantly from Germany, in the 20th century from the Austro-Hungarian Monarchy. Herrmann Knapp (1839-1911), 1859 member of Eye Department in Heidelberg, 1867 immigration, 1879 foundation of American Archives of Ophthalmology, continued to be Editor together with his son Arnold until 1948. Julius Homberger (1839-1872), born in Frankfurt, 1861 immigration, foundation of American Journal of Ophthalmology (1862-1865). Favored specialisation in medicine, Secretary of Section of Surgery in the new American Medical Association 1864, expelled 1868. Adolf Alt (1851-1920), 1875 graduation at the University in Heidelberg, 1875 immigration, 1879 publication of his book in English and German "The Normal and Pathological Histology of the Human Eye". In 1883 second foundation of the American Journal of Ophthalmology, 1896 first president of Western Ophthalmological Society, 1882 member of American Ophthalmological Society. Karl Koller (1857-1944) from Bohemia, 1882 graduation in Vienna, 1884 discovery of anaesthetic effect of cocaine, 1888 immigration, 1889 chief of Mount Sinai Hospital, 1922 Howe-Medal, member of American Ophthalmological Society. Ludwig von Sallman (1892-1975), 1919 graduation in Vienna, 1939 immigration, head of Laboratories of Hermann Knapp Memorial Hospital, New York, 1956 chief of National Institute of Neurological Diseases and Blindness, Bethesda, 1947 member of American Ophthalmological Society, 1959 Howe-Medal. Bertha A. Klien-Montcreiff (1898-1978), 1925 graduation in Vienna, 1928 immigration to Chicago, 1959 Professor at the University of Chicago, clinicopathological correlation of ophthalmoscopic and histologic findings in oil paintings.(ABSTRACT TRUNCATED AT 250 WORDS)
A number of persons important in all fields of human endeavor became blind or were born blind. The reason for the loss of vision varies a great deal, but many of them continued a productive life and contributed to the welfare and advancement of mankind. It is also surprising how many famous people lost one eye or lost nearly all vision in one eye. These were not only soldiers and warriors exposed to accidental traumas, but also writers, scientists and even physicians.
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In summary we can say that the AOS was founded at a time when ophthalmology established itself as an independent scientific medical specialty. A hundred years earlier, in 1750, ophthalmology became an independent surgical specialty when Jacques Daviel of Marseille had begun extracting a cataract instead of merely couching or dislocating the lens. Now in the middle of the 19th century a new era dawned on the ophthalmic horizon. An era which Julius Hirschberg calls "the reform of ophthalmology." It was effected mainly by a group of unusual, gifted and genial scholars. Hermann v. Helmholtz, who not only invented the ophthalmoscope, but established with his handbook physiologic optics as an advanced, sophisticated branch of optics and mathematics; F.C. Donders, who put refraction, refractive errors and accommodation on a sound scientific footing, the great A. v. Graefe, who contributed so much to the concept and treatment of glaucoma, to strabismus, to various diseases of the fundus, to neuro-ophthalmology and to many other fields and finally William Bowman, the great investigator, clinician and surgeon. It was during this time of reform, of fermentation, of maturation, that a group of farsighted American ophthalmologists decided to establish a society to further the aims and objectives of our specialty in America. The time was right; the effort succeeded and our society developed into one of the decisive forces of American ophthalmology. I hope that my address has met the objectives which I had outlined earlier: To present and illuminate the circumstances and external conditions which were effective in 1864 when our society was founded. At the same time I hope I have done justice to the memory of this outstanding American ophthalmologist, Frederick Verhoeff, who contributed so much to the American Ophthalmological Society. On this the quasquicentennial jubilee of the AOS we find the Society healthy and flourishing. May it continue as an association of the most prominent and most promising American ophthalmologists who consider the practice of our specialty a scholarly profession and not a mercenary trade. I can only conclude with wishing the AOS a happy birthday, many successful returns, ad multos annos!
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Metastasis from carcinoma of the conjunctiva is said to be rare. The authors have reviewed the clinical and histopathologic findings of squamous cell carcinoma of the conjunctiva in ten patients from Saudi Arabia in whom distant metastasis developed. There were six men and four women who ranged in age from 45 to 75 years (mean, 61 years). The initial site of metastasis included the parotid gland, submandibular and submaxillary glands, preauricular, cervical lymph nodes, lungs, and bone. Squamous cell carcinoma of the conjunctiva appears to follow a more aggressive course in Saudi Arabia than elsewhere, which appears to be related to delay in management.
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We studied a rare case of congenital myofibromatosis of the orbit as part of a generalized multicentric disease in a 5-month-old boy. The ultrasonographic and computed tomographic findings were those of a low-reflective, firm, vascularized, lesion with heterogeneous internal structure. The histopathologic findings showed vascular channels with large polygonal cells and transition toward myofibroblasts with interwoven collagen fiber bundles.
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A 57-year-old woman had metastatic liposarcoma of the left orbit that underwent transformation. The primary focus in the abdomen, resected in 1975, was a well-differentiated liposarcoma. Later metastases to the neck and orbit were poorly differentiated, pleomorphic, and highly anaplastic liposarcomas. The ultrasonographic and histopathologic correlations of the different stages of the tumor during the disease process were analyzed and compared. This patient's disease had echopathologic similarities to other orbital sarcomas and adult cavernous hemangiomas.
The management of choroidal melanoma with extrascleral extension has been a subject of controversy with some proposing orbital exenteration whenever extrascleral extension is demonstrated and others feeling it to be of no value in increasing survival. We reviewed the cases of 43 patients with extrascleral extension of choroidal melanoma. Although five-year survival had previously been demonstrated to be significantly improved in patients undergoing early orbital exenteration at our institution, extended follow-up in 16 consecutive cases revealed ultimate tumor related mortality to approach that of patients refusing exenteration. Only in cases with nonencapsulated or surgically transected extension did exenteration appear to improve survival. In ten cases with delayed recurrence of tumor in the orbit, exenteration proved to be palliative rather than curative.
The dual properties of two human retinoblastoma cell lines, WERI-Rb1 and Y79, were investigated with immunohistochemistry. Two neuron-specific markers, dopamine-B-hydroxylase (DBH) and tetanus toxin, and an astrocyte-specific marker, the glial fibrillary acid protein (GFAP), were applied for immunohistochemical reactions. With peroxidase-antiperoxidase (PAP) and immunofluorescence techniques, all of the WERI-Rb1 and Y79 cells showed consistently positive results with both neuronal and glial markers. The findings demonstrate that cultured retinoblastoma cells WERI-Rb1 and Y79 have both neuronal and glial properties.