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Biomedical subjects

F Borchard

Publications and source records attributed to F Borchard.

At least 163 records · Page 9Linked to original sources
PubMed1984

Herpes oesophagitis. II. Electron microscopical findings.

Ultra-thin sections obtained from routine biopsy specimens and cytological smears of 3 cases, together with one autopsy case suggestive of herpes oesophagitis, clearly demonstrate herpes viruses. The infected epithelial cells reveal different stages of virus replication and propagation. Cowdry A type inclusion bodies, however, representing early alterations in the course of infection are less frequent. Ground-glass looking nuclei of light microscopical balloon cells and infected multinuclear giant cells of epithelial origin are characteristic changes of the late ulcerative stage of herpes oesophagitis usually seen at the time of detection. These typical virus induced cell changes are mostly to be found at the ulcers edge.

Adolescent↗
PubMed1984

Synchronous double primary malignant lymphoma of low grade malignancy and early cancer (collision tumor) of the stomach.

Collision tumors of the stomach are rare tumors, with about 32 cases reported in the English and German literature. In this report the case of a 65-year-old male with a synchronous primary malignant lymphoma (immunocytoma) and an early cancer of the stomach is presented. A total gastrectomy with esophago-jejunostomy was performed. Postoperatively the affected region was irradiated. 30 months later a re-evaluation did not reveal any recurrence of the disease. The diagnostic and therapeutic problems of collision tumors of the stomach and a possible relationship between the two tumors are discussed against the background of the literature.

Adenocarcinoma↗
PubMed1984

Esophageal cancer. Autopsy findings in 171 cases.

We present the autopsy findings in 171 patients with primary esophageal cancer and compare our results with those of other investigators. The ratio of men to women was 5.84:1. The average age of the women was 72.9 years. The average age of the men was 61.6 years. Squamous cell carcinomas were found in 91.8% of the cases, adenocarcinomas in 6.4% of the cases, and sarcomas in 1.8% of the cases. In the cases of squamous cell carcinoma, there was an ulcerating and infiltrating growth, primarily. In the cases of adenocarcinoma, there was a polypoid exophytic growth and an ulcerating growth. Most of the tumors were localized in the medial third of the esophagus (50.9%), followed by the distal third of the esophagus (39.7%), and, lastly, the proximal third of the esophagus (9.4%). Of all the tumors, 42.7% had an extension of more than 5 cm in the longitudinal axis at autopsy. The trachea was the organ most commonly infiltrated (21%). No metastases occurred in 28.6% of the cases. Lymph node metastases existed in 67.3% of the cases, and visceral metastases were present in 29.8% of the cases.

Adenoma↗
PubMed1983

[Benign epithelial neoplasias of Vater's papilla].

Benign epithelial tumours of the papilla of Vater seem to be very rare. Since 1910, 75 cases have been published. 3 own cases were added. Diagnostic and therapeutic problems were discussed. Benign epithelial neoplasms of the papilla of Vater are precanceromatous. Many cases of carcinoma of the papilla may grow from benign adenomas. The treatment of choice is the local exzision of the adenoma, occasionally necessitating the reimplantation of bile and pancreatic ducts. The main problem is the treatment of adenomas with severe epithelial dysplasia. Metastatic deposits are possible but duodenopancreatectomy seems to be too aggressive an operation in such cases. In cases of severe epithelial dysplasia and focal invasion of the stroma duodenopancreatectomy should be performed. In cases of familial adenomatosis coli adenomas of the papilla should be thought of. In cases of adenomas of the papilla of Vater the colon should be examined to exclude a familial polyposis coli.

Adenoma↗
PubMed1983

[Alcohol and epithelial regeneration in the rat stomach following experimental lesions].

In man, chronic consumption of alcohol has been incriminated as a promoting factor in the development of columnar-lined lower esophagus (Barrett's syndrome). To test the effects of alcohol on the regeneration of squamous epithelium, rats were fed a diet containing 2,5 g alcohol daily for 6 weeks after the junctional region between the squamous epithelium of their fore stomach and the columnar epithelium of their glandular chamber had been injured and denuded. Compared to animals fed an isocaloric control diet the alcohol-fed rats showed neither major macroscopical nor histological differences in the regeneration process of the epithelium. Under the influence of alcohol the mucosal border did not move in an orad direction. Thus, these results fail to support the hypothesis of alcohol promoting the replacement of defects in squamous epithelium by columnar epithelium which is thought to be the major pathomechanism in Barrett's syndrome.

Alcohol Drinking↗
PubMed1982

[Portal vein aneurysm and liver fibrosis in myelofibrosis].

In a 54-year-old woman with oesophageal varices there were the unusual morphological findings of portal-vein aneurysm and irregular hepatic fibrosis. The patient had been treated for 8 years for polycythaemia vera with transition into myelofibrosis. Histologically the hepatic tissue showed occlusion of intrahepatic portal-vein branches by organised thrombi, as well as angiomatous vessels in the sclerosed portal areas. the increased pressure as well as medial atrophy with portal-vein sclerosis were the cause of the portal-vein aneurysm. Portal hypertension may have been the result of intrahepatic vascular obstruction and of the increased flow through the enlarged spleen. It is suggested that interaction of several factors, related to the basic disease of myelofibrosis led to these complex anomalies of the liver and portal vascular system.

Aneurysm↗
PubMed1982

[Diagnosis and therapy of colorectal polyps with special reference to adenomas].

Colo-rectal adenoms occur more frequently in the elderly and should be considered as precancerous. The structural changes of the glandular epithelium are known as dysplasia or atypia and are classified into three grades of severity; the "severe epithelial dysplasia" has all the histological characteristics of a malignant tumor which however has not infiltrated the muscularis mucosa and so has not gained access to the lymphatic system. Whenever these structural changes were present the terms focal carcinoma or carcinoma in situ were used. However in 1976 the WHO accepted to change the nomenclature to "severe epithelial dysplasia", as Morson had proposed. Their aim was to avoid superfluous radical surgical intervention. Whenever severe dysplasia is present in an adenoma, the necessary therapy is the local excision of the adenoma together with its pedick. An exact complete histological examination is necessary. Between 1976 and 1980 we saw 201 cases of adenoma of the colon or rectum at the Surgical Clinic, University of Düsseldorf. 27 of these cases showed severe epithelial dysplasia. As described in the literature there was a correlation between the size of the adenoma, the histological picture and the risk of malignancy. The reexamination of 105 patients showed that there was a significant percentage of recurrency at the site of excision or new polyps at a different site. Therefore, regular checkups are a must for all those patients in whom polyps of the large bowel have been removed.

Adenoma↗
PubMed1982

[Fatal immunohaemolytic anaemia after eating the mushroom Paxillus involutus (author's transl)].

A 49-year-old previously healthy man fell gravely ill after repeatedly eating the mushroom Paxillus involutus. Haemolysis and circulatory shock caused acute renal failure, acute respiratory failure and disseminated intravascular coagulation. The patient died three-and-a-half days after the mushroom meal in protracted shock. In addition to the signs of haemolysis, post-mortem examination revealed signs of intravascular coagulopathy in lungs, kidneys, adrenals, myocardium, liver and spleen. There were also extensive fat emboli to both lungs. An IgG antibody against paxillus involutus extract was demonstrated in the patient's serum. The immunological reaction pattern suggests primarily the formation of an immune complex, which secondarily attaches itself to the erythrocyte surface and causes intravascular haemolysis by activation of the complement chain. In the first instance the diagnosis is made from anamnestic data. In addition to adequate treatment of circulatory shock, immediate plasma separation could provide a chance of effective treatment.

Acute Disease↗
PubMed1982

Thanatophoric dysplasia with cloverleaf-skull. Case report and review of the literature.

The radiologic and morphologic features of thanatophoric dysplasia with cloverleaf-skull could be demonstrated in a neonate who died from asphyxia shortly after birth. Occipital bone hemangiomatosis, a typical histomorphologic finding in cloverleaf-skull, is reported for the first time in a thanatophoric dwarf. Our investigations and the discussion of 26 observations of thanatophoric dysplasia with cloverleaf-skull reported since 1967 do not yet allow complete understanding of the pathogenetic relationship of both malformations. They serve, however, to elucidate some crucial unanswered questions which it is suggested should be studied in future observations of thanatophoric dysplasia with cloverleaf-skull.

Dwarfism↗
PubMed1982

[The diffuse endocrine system and the carcinoids of the alimentary tract. Part I: Orthological aspects and common morphological features of the carcinoids (author's transl)].

Carcinoids arise from the so-called system of diffuse clear cells. Because of common histochemical properties it was proposed in the APUD-concept that these endocrine cells are of neural crest origin. As for the gastrointestinal tract endocrine cells this embryological derivation is disputed. Modern methods have led to the identification of about 18 distinct cell types. - According to the different localization of these cells in the alimentary canal the carcinoids show various histological structures i.e., a solid, trabecular, adenoid, undifferentiated and mixed growth. According to the reactivity to silver salts one can distinguish argentaffin, argyrophil and argyrophobe carcinoids. Biochemically and immunohistochemically some carcinoids are multihormonal, while others show paraendocrine hormone production. Small cell anaplastic carcinomas with endocrine granules are highly malignant variants of the carcinoids. There may be a mixed endo- and exocrine (amphicrine) differentiation in normal cells and in the so-called mucicarcinoids.

APUD Cells↗
PubMed1982

[Isolated varicosis of the small intestine (without portal hypertension) causing massive upper gastrointestinal bleeding (author's transl)].

A case report is given of a 24 year old patient who had relapsing massive gastrointestinal bleeding from varices in the duodenum and jejunum, due to occlusion of the mesenterial vein. There is only one similar case described in the literature. 97 patients with varices of the small intestine have been described; in 41 of these cases there was extrahepatic, in 47 intrahepatic portal hypertension. In 60 of the 91 cases varices were found in the duodenum, less frequently in the ileum or jejunum too. In another 10 cases varices had formed around an ileostomy. In 1/3 of all cases abdominal surgery had preceded formation of varices in the small intestine. Pathogenesis, diagnosis and therapy are discussed.

Adult↗