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Biomedical subjects

F Borchard

Publications and source records attributed to F Borchard.

At least 181 records · Page 10Linked to original sources
PubMed1981

Acute monocytic leukemia complicating combined-modality therapy for localized childhood Ewing's sarcoma.

Rapidly fatal acute monocytic leukemia occurred in an 11-year-old by 33 months after the beginning of irradiation and chemotherapy for non-metastatic pelvic Ewing's sarcoma. At autopsy, no recurrent primary disease was seen. An analysis of this case together with a review of the literature suggests therapy-related leukemogenesis. Thus, the decline in mortality rate for childhood cancer may be accompanied by an increased incidence of second neoplasms in cured children having the potential of a normal life span.

Antineoplastic Agents↗
PubMed1980

[Esophageal stenosis in sjögren's syndrome].

Dysphagia in Sjögren's syndrome may be caused by xerostomy, pharyngoesophagitis and esophageal membranes. This is the first report on a tubular upper esophageal stenosis in a 71 year old woman with Sjögren's syndrome who developed progressive dysphagia. It is suggested, that this stenosis was due to chronic inflammatory processes and secondary sclerosis of deep layers in the esophageal wall. Bouginage was adequate symptomatic therapy. Tubular esophageal stenosis is regarded as gastrointestinal manifestation of Sjögren's syndrome.

Aged↗
PubMed1980

Morphology of cardiac nerves in experimental infarction of rat hearts. I. Fluorescence microscopical findings.

The effect of ischemia on the catecholamine content and morphology of autonomic cardiac nerves was studied in experimental myocardial infarction in 65 rats with coronary ligation. The area of infarction, of ligation and other regions of the heart were investigated at hourly and daily intervals up to 9 weeks after ligation. During the first 4 h there is a slight reduction of fluorescence in the area of infarction and a focal, inconstant diffusion of adrenergic transmitters shown by Falck method. After 4 h an increasing loss of catecholamines is observed while the fluorescence of the adrenergic nerves in the adjacent myocardium is maintained or even increased. After 8 h the fluorescence of terminal nerve fibres has decreased; such changes also take place in bigger perivascular nerve trunks. After 16 h specifically fluorescent nerves can be identified only weakly. After two days catecholamine fluorescence has faded. The serotonin fluorescence of mast cells is constant except for focal degranulation. In later stages non-specific fluorescence is caused by fatty degeneration of myocardial cells and lipid-laden phagocytes. The results are discussed in respect to the local effects of catecholamines liberated during the early phase of infarction.

Animals↗
PubMed1980

Morphology of cardiac nerves in experimental infarction of rat hearts. II. Electron microscopical findings.

Alterations of cardiac nerves in myocardial infarction were investigated by electron microscopy after differing intervals in 28 rats. During the first 4 h there are, in non-myelinated nerves within the myocardium, a swelling of the axoplasm with the occurrence of 'pale' axons and swelling of axonal mitochondria and neurosecretory granules. After bursting of the axolemma, these are spilled into the adjacent interstitial space. After 4 h first myelin figures are observed, and in some axons an accumulation of neurofilaments takes place. During the second to seventh day an extensive vesicular disintegration of axonal structures develops. Because of regressive changes, axons cannot be identified with certainty within the necrosis. After two or three weeks nerves with lamellar enfoldings of cytoplasmic processes corresponding to Büngner bands can be seen at the infarction border. These nerves may contain only a few residual axons. Myelinated nerves show a mainly vesicular disintegration. The results are discussed with regard to their functional significance and the special conditions of the animal model, in which ligature of the coronary artery may not only produce ischemia, but may also, by simultaneous ligature of the adjacent cardiac nerves, induce Wallerian degeneration.

Animals↗
PubMed1980

[Suppression of bone marrow in neonatal herpes simplex virus infection under virustatic therapy with adenine arabinoside-5'-monophosphate (author's transl)].

The case of a generalized neonatal herpes-simplex-virus infection with lethal outcome is presented. Therapy with adenine arabinoside-5'-monophosphate (ARA AMP) was employed with a good virustatic effect. Suppression of bone marrow and a possible immunological suppression was seen at low dose level already. Therefore in newborn and prematures we suggest a cautious regimen in employing this substance, which was until now considered to have no serious side effects.

Arabinonucleotides↗
PubMed1979

Detection of HBsAg containing cells in liver biopsies by different stains and classification of positively reacting ground-glass hepatocytes.

The diagnostic significance of orcein, aldehydthionine, and chromotrope anilinblue stains for the demonstration of HBsAg containing hepatocytes was investigated in 602 unselected liver biopsies. Five types of specifically stained ground-glass hepatocytes (GGH) were distinguished: Type I showed a positive staining reaction of the cytoplasmic periphery (marginal GGH), type II a diffuse staining of the total cytoplasm (diffuse GGH). Type III contained round or oval globular positive cytoplasmic masses (globular GGH). Type IV showed only very small round, drop-like or sickle-shaped positive structures (spotty GGH). The GGH with fatty changes were designated as type V. In all carriers and patients with minimal hepatitis GGH, mostly type I and II, appeared in extensive clusters within the lobules. In chronic persistent hepatitis, there were moderately numerous, partly grouped, partly disseminated ground-glass hepatocytes of type II and III. In chronic active hepatitis there were only a few GGH of type IV. In acute viral hepatitis, there were no typical GGH, however, positively stained phagocytes were seen. The intracellular antigen localization and the intralobular distribution of GGH are considered to be the result of an immune reaction. Single so-called 'metabolic' GGH sometimes showed similar pictures. However, they could usually be distinguished from virus containing GGH because of their granular cytoplasmic structure and a lower staining intensity in the applied stains. Among the three stains the orcein stain yielded the best results. In some cases with HBsAg-positive chronic active hepatitis virus infection could not be proved by means of staining.

Biopsy↗
PubMed1979

Incidence of epithelial dysplasia after partial gastric resection.

Because of the higher risk of cancer in the gastric stump, an increased incidence of pre-cancerous conditions should be exspected also in the resected stomach. Therefore, a combined endoscopic and bioptic study was performed in order to investigate the incidence of dysplasias in the gastric stump after resection for benign conditions. Among 101 patients with gastric resection, 2 cases were excluded from this study because of preceeding gastric cancer and one because of cancer of the gastric stump. In 43 of the remaining 98 patients, a Billroth-I-resection (gastroduodenostomy) had been carried out. In the remaining 55 patients with a Billroth-II-resection (gastroenterostomy) 9 had an additional enteroanastomosis of Braun whereas in the residual 46 patients this enteroanastomosis was lacking. This distinction was made because of a facultative or obligatory bile reflux. The average age of the B-I-group was 68 years, of the B-II-group with enteroanastomosis 69 years, and the B-II-group without enteroanastomosis 62 years. A non-operated group matched for age served as control group. Biopsy particles from the anastomotic region were gained by endoscopy and cut in step sections. The classification of dysplasias (degree I-III) followed the criteria given by Nagayo as modified by Grundmann. Inflammatory reactive changes were separated from these. A few changes could not be classified definitely and were listed as unclassified dysplasia. While dysplastic changes of low degree were quite numerous in every group, the dysplasias of higher degree were only found in a small number of cases. In the 46 cases with B-II-resection without Braun's enteroanastomosis, there were 5 dysplasia II and 3 dysplasia II. In the 9 cases with B-II-resection and with Braun's enteroanastomosis, there was 1 dysplasia I and no dysplasia III. In the 43 patient with B-I-resection only 2 dysplasia II and no dysplasia III were found. In the control group of 98 patients matched for age there were only 5 cases with dysplasia I and 1 case with dysplasia III. Patients with higher degrees of dysplasia showed a higher age and a longer interval after operation. There was also a correlation between higher degrees of dysplasia and severe atrophic changes in the mucosa. Correlating the degree of dysplasia with the reason for gastric resection, most of the dysplastic changes occurred in patients resected for gastric ulcer, whereas cases resected for duodenal ulcer showed only 2 dysplasias I. The discussion refers to the few data about dysplasia of the gastric stump available from the literature. Atrophic and increased regenerative changes obviously play a role in the pathogenesis of these dysplastic changes. As a causative factor the role of bile reflux is discussed. A further diagnostic and therapeutic regimen for the different forms of dysplasia is proposed.

Aged↗
PubMed1979

[Localized retroperitoneal xanthofibrogranuloma simulating a pancreatic tumor].

The diagnosis of xanthofibrogranuloma is difficult. This is examplified by observations in a 46-year-old man with a palpable tumor in the left upper abdomen. Even modern diagnostic procedures like ultrasound, angiography and ERCP were unable to clarify the diagnosis. Only when laparotomy demonstrated a circumscript tumor, 7 x 7 x 10 cm in size, below the pancreas which was enucleated, the suspicion of a pancreatic tumor could be dismissed. The different clinical pictures of xanthofibrogranuloma ware discussed. Etiology is still unknown. Therapy as a rule should be surgical.

Celiac Artery↗
PubMed1978

[Chemically induced carcinogenesis of stomach of the rat after vagotomy and resection (author's transl)].

180 male Wistar-rats were daily exposed to 30 and 100 mg MNNG/1000 ccm tapwater. After 7 weeks exposure a truncal vagotomy with pyloroplasty or a Billroth-II-resection was performed in 25 animals of each dosage-group. 80 rats were not operated. The incidence of carcinomas in the Billroth-II-rats of both dosage-groups was evidently higher than in the exposed controls. In the vagotomized rats an increased occurrence of carcinomas could not be observed.

Animals↗