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Biomedical subjects

F Bloch

Publications and source records attributed to F Bloch.

At least 55 records · Page 3Linked to original sources
PubMed1986

Campylobacter-like organisms and surface epithelium abnormalities in active, chronic gastritis in humans: an ultrastructural study.

A prospective light and electron microscopic study of repeated endoscopic gastric biopsy specimens obtained from 10 patients presenting at the first examination for long-standing erosive gastritis was performed. In nearly all specimens from 7 patients, spiral bacteria were found in close contact to the surface epithelial cells and associated with active inflammatory changes. These organisms appeared similar to those recently described as gastric "campylobacter-Like organisms" (GCLO). It is possible that they are related to unusual anaerobic spirochetes. In the specimens obtained after antibiotic-therapy the bacteria were few in number and damaged. At the ultrastructural level, the presence of cell necrosis and autolytic intracytoplasmic vacuoles combined with damaged bacteria may suggest a relationship between GCLO surface colonization and erosive epithelial abnormality. Such colonization does not occur in normal mucosa.

Biopsy↗
PubMed1986

[Ultrastructural markers in LAV-HTLV III virus infection: study of the rectal mucosa in 16 patients].

Ultrastructural study of rectal mucosa was performed in 6 patients with AIDS related complex (ARC) and in 10 patients with AIDS. There were 16 men (mean age: 39.1 years): 8 homosexuals, 3 Haitians, 2 Africans and 3 IV drug abusers, all having significant titers of LAV antibodies. Two types of ultrastructural markers were observed: tubuloreticular structures (TRS) were found in endothelial cells, lymphocytes and macrophages in 1/6 ARC patients and 10/10 AIDS patients. TRS have already been described in various pathological situations and seem to be related to alpha-interferon, test tube and ring shaped forms (TRF) were observed in lymphocytes and macrophages in 0/6 ARC patients and 6/10 AIDS patients. TRF have been rarely reported previously. The 6 AIDS patients with TRF were 4 homosexuals and 2 Haitians. In two of three of these patients in whom repeated ultrastructural studies were performed, the same markers were found. All AIDS patients with TRF died within a mean time of ten months after the diagnosis had been established, whereas 1/4 AIDS patients without TRF died within seven months and the three others survived for more than 14 months. These data suggest that the association of TRS and TRF in the rectal mucosa could be specific of AIDS. In LAV/HTLV III retro-virus infection, this association is an aggravating factor.

Acquired Immunodeficiency Syndrome↗
PubMed1985

[The care of elderly patients by their relatives].

New concepts are needed for the still increasing number of geriatric patients who require long term institutional care and for the often difficult situation of caregiving relatives. We investigated the possibility to integrate relatives of institutionalized patients in the nursing care. 323 geriatric patients were randomly selected and the relatives contacted. Only four (1%) had no relatives or friends. Of 86% of the patients it was possible to interview 343 relatives or close friends. Of those 147 (43%) were favorably disposed towards a cooperation in the care with the ward staff. Persons willing to cooperate were characterized by female sex, middle class status, good health, not too demanding jobs, and close contacts prior to institutionalization of their next of kin. In a second part 29 of 196 relatives were willing to take part in a pilot project. Unfortunately, for technical reasons only five patients could be hospitalized on the experimental ward in the given time. The practical experience demonstrated that relatives can cooperate on a part time basis with the nursing staff in the care of institutionalized geriatric patients. It is estimated that probably 12% of the geriatric patients in institutions have relatives willing and capable to take part in the nursing or other activities on the ward. Smaller nursing facilities appear more suitable than large geriatric clinics for this type of cooperation.

Aged↗
PubMed1985

[Human pentastomiasis: clinical, radiological and x-ray computed tomographic study of a case].

A case of abdominal pentastomiasis in a 38-year-old Congolese man is reported. This parasitic disease has been described in Central Africa and South East Asia. The patient presented with unexplained permanent abdominal pain. The peritoneal and hepatic localisations of the parasite were recognized on plain abdominal film and documented by ultrasonography and CT scan studies. At laparoscopy multiples adherences were found, in spite of the fact that no previous abdominal surgery had been performed. These findings suggest a possible correlation between the clinical manifestations and the anatomic lesions in this disease which is usually considered to be asymptomatic.

Adult↗
PubMed1983

[Contribution of the family in the care of the chronically ill aged].

As part of the Swiss National Research Programm No. 8 (Economy and Efficacy of the Swiss Health System), we evaluated the participation of relatives in the care of institutionalized, chronically ill elderly parents. 323 patients were selected at random. Of 473 relatives and friends it was possible to interview 343. Men below the age of 80 were, cared for significantly more often at home in comparison to women. Care was in most instances provided by closely related women, usually from the next generation (daughters and daughters-in-law). In this group a majority participated in nursing care for institutionalized elderly relatives. Only close relatives appear to be willing to carry the burden of nursing care over a long period of time, whereas friends, neighbours, and distantly related family members are not. Economic problems arise mainly for men, less so for women. The latter are surprisingly often already involved in caring for an additional handicapped or elderly family member.

Aged↗
PubMed1982

[Care of elderly chronically ill patients at home].

In a survey of 261 chronically ill elderly 43 are found to be supported at home by family members. In comparison to institutionalised patients significantly more men are nursed at home. Members of lower socioeconomic groups are overrepresented in the home care group. Only close family members (spouse and daughter) contribute in significant numbers to home care. In addition formal support is necessary in the majority of patients (periodic hospitalisation in more than 50%). In the present situation, only a minority (mainly married men) is cared for at home.

Aged↗
PubMed1982

[Asymptomatic abetalipoproteinemia associated with partial apoprotein B deficiency: a familial case report].

The authors report a case of familial asymptomatic abetalipoproteinemia. The propositus has total abetalipoproteinemia associated with a partial apoprotein B defect. His two daughters have a subtotal betalipoprotein deficiency. This familial case, with autosomal dominant transmission, seems different from other reports. It supports the hypothesis that the primary involvement is a deficiency in apoprotein B synthesis, which appears more closely correlated with clinical symptoms.

Abetalipoproteinemia↗
PubMed1981

Hepatocyte localization of hepatitis B core and surface antigens in renal transplant recipients. An ultrastructural prospective study.

A prospective series of 45 liver biopsies taken from 22 renal transplant patients was investigated for the presence of hepatitis B antigen core (HBc) and surface (HBs) components by electron microscopy. At the time of each biopsy serum HBs Ag was sought by radioimmunoassay. Sections were taken for the detection of HBs Ag by immunofluorescence. In seropositive patients, intravesicular tubular structures resembling HBs Ag were found in 61% of biopsies while the intranuclear core HBc was present in 69%. No correlation could be made between the ultrastructural pattern of the viral components and the intensity of the histological liver damage. During the follow up, there was an accumulation of both HBs and HBc Ag even in a period as short as 1 year. The 9 liver specimens examined after three years of transplantation showed a marked accumulation of both antigens. Thus the expression of HB Ag at the hepatocellular level seems to correlate better with the duration of antigenaemia than with the histological pattern. Lastly, on matched semithin and ultrathin sections, the ground glass appearance of cytoplasm appeared to correlate with smooth endoplasmic reticulum distorsion, irrespective of the simultaneous presence or absence of intravesicular tubular structures. The sanded nuclei expressed a rare massive accumulation of core antigen.

Biopsy↗