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Biomedical subjects

E Yilmaz

Publications and source records attributed to E Yilmaz.

At least 109 records · Page 6Linked to original sources
PubMed1995

Cutaneous histoplasmosis in a child with hyper-IgM.

Immunodeficiency with hyperimmunoglobulinemia M is a rare disease characterized by very low levels of IgG and IgA and normal or high levels of serum IgM and IgD. Recurrent and severe systemic infections with pathogenic bacteria are frequent if immunoglobulin replacement therapy is not given. Histoplasmosis is a systemic granulomatous mycosis due to Histoplasma capsulatum and characterized by a particular affinity for the reticuloendothelial system. Glabrous skin involvement in histoplasmosis is highly unusual except in patients with advanced human immunodeficiency viral disease. Cutaneous histoplasmosis and granulomatous reaction were diagnosed in a 5-year-old boy with hyper-IgM disease. The lesion improved after oral ketoconazole therapy. To our knowledge, this is the first case of cutaneous histoplasmosis associated with hyper-IgM to be reported.

Child, Preschool↗
PubMed1995

Visual discrimination of local surface depth and orientation.

Many theoretical analyses of 3-dimensional form perception assume that visible surfaces in the environment are perceptually represented in terms of local mappings of metric depth and/or orientation. Although this approach is often taken for granted in the study of human vision, there have been relatively few attempts to demonstrate its psychological validity empirically. In an effort to shed new light on this issue, our research has been designed to investigate the accuracy with which observers can discriminate metric depth and orientation intervals on smoothly curved surfaces. Observers were presented with visual images of surfaces defined by shading and/or texture, on which two pairs of points were designated with small dots. In Experiment 1, their task was to identify which pair of points had a greater difference in depth; in Experiment 2 they were required to judge which pair had a greater difference in orientation. The Weber fractions obtained for these tasks were 10 to 100 times greater than those that have been reported for other types of sensory discrimination, indicating that the perception of metric structure from these displays is surprisingly coarse grained.

Attention↗
PubMed1994

Importance of serum anticardiolipin antibody levels in coronary heart disease.

During the past 10 years it has been shown that some patients with antibodies to phospholipids develop recurrent venous and arterial thromboses, repeated fetal loss, and thrombocytopenia. The aim of this study is to determine the importance of levels of serum anticardiolipin antibodies (ACA) in patients with coronary heart disease (CHD). The study population consisted of 76 CHD patients (Group 1) and 22 healthy subjects (Group 2). Group 1 comprised three subgroups: (1a) 32 patients with acute myocardial infarction (MI), (1b) 22 patients with chronic CHD and a history of MI, and (1c) 22 patients with CHD but without previous MI. Immunoglobulin G anticardiolipin antibodies (IgG ACA) and immunoglobulin M anticardiolipin antibodies (IgM ACA) were detected by ELISA. High IgG ACA levels were found in 36 patients (47%) in Group 1, but no high levels were found in the control group. IgM ACA levels showed no significant difference between the two groups. The ACA (IgG and IgM) levels showed no correlation with age, gender, risk factor profiles, platelet counts, coronary artery lesions, left ventricular function, and morbidity and mortality rates during the follow-up period of 22 months. As a result, measurement of ACA in CHD patients is unlikely to yield information that is diagnostically or prognostically important. The importance of serum anticardiolipin antibody levels in the natural history and prognosis of CHD is still undetermined and remains to be clarified.

Adult↗
PubMed1994

Sodium chloride deficiency in cystic fibrosis patients.

Sodium chloride deficiency (SCD) was observed within the 1st year of life in 12 of 46 cystic fibrosis (CF) patients between July 1989 and September 1992. All patients showed sweating, loss of appetite, fever, vomiting, irritation, dehydration, weakness, and cyanosis during an attack. Mean plasma sodium, potassium and chloride levels were 122.9 (range 106-135), 2.5 (range 1.6-3.5), and 73.3 (range 60-90) mEq/l respectively. Alkalosis and elevated plasma renin activity were detected in all patients. Of the patients, 50% showed microscopic haematuria, and hypercalciuria was detected in two out of four patients. Low urinary sodium and high urinary potassium were observed in the four examined patients. Increased creatinine, BUN and uric acid values returned to normal with treatment. All the patients were treated initially with intravenous fluids and electrolyte solutions. All patients were less than 7 months of age during the first attack, five received only breast milk and the others breast milk with formula milk. Their oral salt supplement was 2-4 mEq/kg per day, which is recommended for CF patients, but could be deficient in excessively sweating infants. The genotype of these patients might be cause of high salt losses. F508 is the most common mutation with the frequency of 38% in our CF patients with SCD, but the frequency of unknown mutations is high (54%).

Alkalosis↗
PubMed1994

Interferon therapy for Behçet's disease.

BACKGROUND: Behçet's disease was first described in 1937 as a trisymptom complex. No standard therapy has been established. Its cause is presumed to be viral or immunologic. OBJECTIVE: We sought to determine whether patients with Behçet's disease benefit from interferon, which has antiviral, immunomodulatory, antiproliferative, and antitumoral properties. METHODS: Fourteen patients were initially given 3 MU interferon alfa-2a subcutaneously three times per week. The doses were gradually increased to 12 MU. Each patient received a total dose of 216 MU during the 2-month study. Therapy with 9 MU interferon alfa-2a once a month was continued in half the patients. All patients were observed before and after treatment for 6-month periods, and all symptoms were recorded. RESULTS: All patients were symptom free by the end of the 2-month treatment period. The frequencies of oral and genital ulcers as well as pustular vasculitis decreased significantly in the posttreatment period as compared with the pretreatment period. CONCLUSION: The data suggest that interferon treatment appears to be effective for patients with Behçet's disease.

Adolescent↗
PubMed1994

Allele frequencies of Mp6D-9 and GATT markers in 32 Turkish cystic fibrosis families.

The allele frequency of GATT and Mp6D-9 markers was investigated in 32 cystic fibrosis (CF) families. The GATT6 allele was found to be significantly associated with the delta F508 mutation. The Mp6D-9 allele 2/GATT6 haplotype was the major haplotype of the mutant alleles. Further analysis of CF alleles for population-specific mutations is underway so that a more direct approach can be taken, especially for families seeking prenatal diagnosis.

Alleles↗
PubMed1993

Arteria thyroidea ima arising from the brachiocephalic trunk with bilateral absence of inferior thyroid arteries: a case report.

The anomalous first parts of the left and right subclavian aa. had no inferior thyroid aa. in the neck region. The thyroidea ima a. was found to arise from the brachiocephalic trunk, and bifurcated into two branches almost immediately after its origin. These branches ascended in front of the trachea and entered the bases of the right and left lobes of the thyroid gland. The left vertebral a. arose from the aortic arch in the superior mediastinum. The possible existence of this anomaly is important for parathyroid localization studies, in neck surgery and especially in tracheostomy.

Arteries↗
PubMed1993

Detection of Mycobacterium tuberculosis in sputum samples by polymerase chain reaction using a simplified procedure.

A repetitive sequence of Mycobacterium tuberculosis DNA was amplified by polymerase chain reaction (PCR), from sputum samples, for the diagnosis of pulmonary tuberculosis. The method of heating the sample in a boiling water bath to break down the bacterial cell wall and to release the DNA was compared with that of enzymatic lysis of bacteria and then phenol-chloroform extraction of DNA. Heating the sample was the better method with a sensitivity of approximately 10 microorganisms. A total of 78 sputum specimens prepared by heating were examined by PCR, and the results were compared with the results of acid-fast stained smears, cultures, and clinical data. M. tuberculosis was detected by PCR in all smear- and culture-positive and smear-negative, culture-positive cases. Additionally, PCR was capable of detecting four of nine cases which were smear and culture negative but clinically suspected of tuberculosis. DNA amplification by PCR is a sensitive and specific method for the diagnosis of tuberculosis, and with this simplified DNA isolation procedure it can be used in routine clinical practice.

Bacteriological Techniques↗
PubMed1993

Mutation analysis in Turkish phenylketonuria patients.

Forty-four classical PKU patients have been screened for various mutations. The newly identified IVS 10 splicing mutation was found in 32% of the mutant alleles and comprises 74.5% of the mutations that could be typed: 261arg-gln (6.8%), 158arg-gly (2.3%), 252arg-trp (1.1%), 280glu-lys (-), and 272gly-stop (-) were the other mutations that were screened.

Alleles↗
PubMed1993

Somatotopic organization of the axons innervating the superior rectus muscle in the oculomotor nerve of the rat.

It has long been known that the pupillomotor fibers have a localized course in the dorsomedial periphery through the subarachnoid portion of the oculomotor nerve. However we do not have detailed knowledge about the organization of the fibers innervating individual extraocular muscles. This subject is of clinical importance for locating the site of lesions in patients with partial oculomotor nerve palsies. In this study the peripheral course of the axons innervating the superior rectus muscle were studied in the subarachnoid portion of the oculomotor nerve of the rat by making multiple injections of horseradish peroxidase solution into the muscle and reacting the nerve with tetramethylbenzidine as a chromogen. Coronal sections of the nerve showed that the axons innervating the superior rectus muscle were localized in the dorsal part of the nerve. Within the precavernous portion these axons showed a wider distribution invading dorsomedial and dorsolateral parts of the nerve.

Animals↗
PubMed1993

An anatomic variation of the deltoid muscle (case report).

A bilateral anomaly of deltoid muscles was found in cadaver dissection of a middle aged male. Posterior part of the muscle was enclosed with a separate fascial sheath. There was no concomitant muscular anomaly in any part of the body.

Arm↗
PubMed1993

Ligamentum teres hepatis: an unusual variation.

We report a variation of the ligamentum teres hepatis in 45 year old male cadaver. The ligamentum teres hepatis was found between the layers of the rectus sheath. A review of the literature reveals no additional reports of similar anomaly. There was also a variation in the form of the liver.

Humans↗
PubMed1993

An unusual insertion of the palmaris longus muscle.

In the course of an anatomical dissection at the School of Medicine, a variant form of the palmaris longus muscle was found on the right side; the fellow muscle of the left side being normal. The palmaris longus concerned was found to arise by fleshy fibers from the common tendon for the flexores antebrachii muscles to be divided into a lateral and a medial tendon. The lateral tendon of the muscle was inserted onto the thenar fascia and the scaphoid bone while the medial tendon was being inserted onto the hypothenar fascia and the triquentral bone.

Adolescent↗
PubMed1992

Unrotated left kidney associated with an accessory renal artery.

During routine dissection, a rare anomaly of the kidneys and their vessels was observed in a 55-y-old male cadaver. The anomaly consisted of an unrotated left kidney with partly extrarenal calyces and pelvis. In addition to its normal artery, the left kidney received a branch originating from the inferior end of the aorta.

Humans↗
PubMed1992

Bilateral anatomical anomaly of anterior bellies of digastric muscles.

During the gross anatomy dissection of the submandibular region, both anterior bellies of the digastric muscles, especially the left one, were found to be enlarged. They were arranged as two parallel asymmetric bands extending from the hyoid bone to the chin. The posterior bellies of the digastric muscles were normal. The suprahyoid muscles showed no abnormalities. This anomaly represents an anatomical variation in the mylohyoid digastric muscle group in the floor of the mouth.

Humans↗