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Biomedical subjects

E Somogyi

Publications and source records attributed to E Somogyi.

At least 55 records · Page 3Linked to original sources
PubMed1987

Experimental investigation of the effect of cardiac glycosides on the ischemic coronary circulation.

The paper presents new evidence of the vasoactivity of cardiac glycosides in the myocardium. Experiments were performed on the in situ dog heart. The present study primarily focuses on the analysis of K-strophantoside induced topo-optical and thermographic alterations in acute myocardial ischemia. The strong binding of K-strophantoside to the coronary vessel wall and the endothelial cells was found to be accompanied by vasoconstriction in the regionally ischemic heart muscle. The potential clinical impact of these findings on therapy is briefly evaluated.

Animals↗
PubMed1986

Electron microscopic demonstration of viruses and bacteria in cardiac myocytes from victims of sudden cardiac death.

In 7 men and 1 woman who died suddenly the functionally important areas of myocardium in the sino-auricular area and the subendocardial layers of left ventricle were obtained by necropsy no more than 3 h after death, and then prepared for study by electron microscopy. In three cases of five, in whom the cause of death was cardiovascular insufficiency, viral particles and bacteria were identified. In three other cases of sudden non-cardiac death they were not found. Viruses were found only in working cardiomyocytes, but near the sinus node. Bacteria were found in left ventricular subendocardium. Intercellular junctions between virus-damaged myocytes and intact cells were preserved. Based upon the functionally important sites where they were found, associated degeneration near them, and preservation of contacts among myocardial cells there, viruses and bacterial infections may play an important role in the patho-physiologic events leading to some cases of sudden death.

Adult↗
PubMed1985

Application of a vascular graft material (Solcograft-P) in experimental surgery.

The implantation and post-implantation behaviour of a Solcograft-P vascular prosthesis in the aortic, aorto-iliac, carotid and vena caval positions in dogs was studied up to 100 d post-surgery in order to assess the suitability of this vascular material for use in man. Solcograft-P is prepared from the carotid arteries of calves by crosslinking the collagen stroma using adipyl dichloride. During the postoperative follow-up period of 3 month, 100% of the aortal grafts, 80% of the aorto-iliac bypasses, 60% of the vena caval grafts and 35% of the carotid implants remained patent. The biochemical properties of the Solcograft-P are better than those of Solcograft, its predecessor. The intimal lining was consistently smooth and homogeneous in grafts of biological origin, and no aneurysm was observed. Infection and early thrombosis occured no more frequently than with other grafts. The new Solcograft-P, crosslinked via ester and amide groups, seems to represent a real improvement over Solcograft. Our results suggest that Solcograft-P should prove valuable in various cases of reconstructive vascular surgery of the lower limb, especially when the autologous vena saphena magna is not available, and its mechanical properties may well prove suitable for both arterial and venous replacement.

Animals↗
PubMed1985

The history of forensic medicine in Hungary.

The XIIIth Congress of the International Academy of Forensic and Social Medicine will be held in September 1985, in Budapest, and for this occasion we gave a brief account of the past and present state of forensic medicine in Hungary.

Education, Medical, Graduate↗
PubMed1985

Electron microscopic autoradiographic study of heart muscle calcium in experimental cardiac glycoside poisoning.

The role of calcium was investigated in myocardial cell necrosis induced by cardiac glycoside. Experimental poisoning caused an increase of Ca45. Excessive intracellular calcium uptake must be the determining factor in the aetiology of myocardial cell damage. The possible involvement of calcium increase in the genesis of cardiac glycoside induced myocardial cell necrosis is discussed.

Adenosine Triphosphatases↗