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Biomedical subjects

E Somogyi

Publications and source records attributed to E Somogyi.

At least 73 records · Page 4Linked to original sources
PubMed1985

Post-mortem examination of the heart in cases of sudden death.

Sudden unexpected death is an important topic of forensic medicine. Several papers have been published on the morphological changes of the coronary arteries and the myocardium in sudden cardiac death. Forensic pathology demands more and more accurate methods of postmortem diagnosis of early ischaemic lesions of the heart muscle that occur shortly before death and which, in the absence of other explanations, may presumably be related to the cause of death. The cause of death is often evident from post-mortem findings, still in a number of cases the diagnosis may be doubtful. The application of electron microscopy has increased rapidly over recent years and the electron microscopic investigation of post-mortem biopsy material may be useful in narrowing down the cause of death. This report presents the results of electron microscopic and cytochemical studies of the myocardium in cases when death had occurred at a precisely recorded time.

Calcium↗
PubMed1985

[Ultrastructural analysis of viral and bacterial lesions in human sudden cardiac death].

Sinoatrial node, perinodular working myocardium of the right atrium and subendocardial muscle fibers of the left ventricle of 8 persons who died suddenly at the age of 23-69 years were studied ultrastructurally. In 1% of working cardiomyocytes, in 2 out of 5 cases of sudden cardiac death, viruses were detected. Myofibrils were destroyed in the damaged myocytes but the contact zones with undamaged myocytes remained intact. Rod-like bacteria were observed in the interstitium of the subendocardial myocardium of the left ventricle in one case. Destructive changes of the mitochondria, myofibrils and intercalated discs were found in the myocytes adjacent to bacteria. Viruses and bacteria were absent in 3 control cases. The possible role of viruses and bacteria in the development of sudden cardiac death is discussed.

Adult↗
PubMed1984

The use of chromosomes in paternity actions.

The authors performed paternity investigations for many years by the order of the court and on this basis they give expert opinion in discussed paternity cases. In recent years opinion was given with the help of chromosome studies in cases where neither blood group nor anthropology investigations were decisive. From a couple of hundred persons the thickening of the heterochromatic part of the chromosomes studied by C-band methods is evaluated (1, 9, 16, Y) and (within this) the occurrence of total or partial inversion is observed. The frequency of polymorphism was studied among the chromosomes investigated by the C-band technique. From these data the authors aimed at deducing exact relationship: and forming the most exact possible expert's opinion in this problem which is of social significance as well.

Adolescent↗
PubMed1983

[János N. Rupp].

Explore the source record for details and available documents.

Forensic Medicine↗
PubMed1983

Electron-cytochemical detection of endogenous nickel in the myocardium in acute carbon monoxide poisoning. Applicability of a new cytochemical technique in forensic medicine.

After acute carbon monoxide poisoning (inhalation, dogs; perfusion, rats; postmortem, humans) endogenous nickel was cytochemically detected in heart muscle by dimethylglioxime reaction. Dimethylglioxime cytochemical reaction, in each case at the COHb level, was always positive in experiments and in postmortem samples. A nickel ion accumulation in the heart muscle above 30 rel.% of COHb was suggested. A possible role of nickel ion in the pathomechanism of the acute carbon monoxide poisoning was supposed. This dimethylglioxime cytochemical technique is applicable in forensic medical practice, primarily because it is not disturbed by autolysis.

Animals↗
PubMed1983

Comparative topo-optical investigation of cardiac glycoside localization.

The aldehyde-bisulfite-toluidine blue (ABT) reaction is a selective topo-optical test of vicinal-OH and amino-OH groups. The localization of cardiac glycoside was investigated morphologically. After digoxin the sarcolemma membranes, capillaries and sinus node showed strong basophilia and negative birefringence. The topo-optical reaction are useful for the histopathological examination. The new method gives the possibility to the digoxin intoxication with a high specificity.

Animals↗
PubMed1983

Cytochemical demonstration of the molecular forms of cardiac glycosides in the heart muscle.

Selective topo-optical staining of vicinal-OH groups with aldehyde-bisulphite-toluidine blue (ABT) has been used for studying the localization and molecular structural order of cardiac glycoside in heart muscle. The glycoside has strong metachromatic basophilia and negative birefringence. In addition to confirming the electron microscopic suitability of the ABT reaction has offered also ultrastructural evidence for the reliability of the topo-optical method. The localization appeared to be in extracellular connection with the outer side of sarcolemma membrane, internal surface of endothelial cell, and in the subsarcolemmal cysterne. The findings suggest that the topo-optical reaction is suitable for molecular analysis of cardiac glycoside.

Aldehydes↗
PubMed1983

Comparative electron-microscopic investigation of postmortem human heart muscle biopsy.

Based on Harvard criteria findings, comparative morphological investigation on postmortem heart muscle biopsy following coronary insufficiency after sudden cardiac death have been reported. The subendothelial layer of the left ventricular wall has revealed a severe interstitial edema, various types of actin-myosin filamental destruction, mitochondrial damage, and disseminated muscle fiber necrosis. One of the first alterations observed was the change in transmembrane calcium and intracellular calcium metabolism. A decrease in succinic dehydrogenase and cytochrome oxidase activity was discovered early.

Adolescent↗