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Biomedical subjects

E Schuster

Publications and source records attributed to E Schuster.

At least 91 records · Page 5Linked to original sources
PubMed1984

[Behavior of ACTH and cortisol in acute myocardial infarct].

In 30 patients with acute myocardial infarction in 4-hour intervals the temporary course of the ACTH and cortisol in the plasma was pursued up to the 60th hour. Here 3 different patterns of behaviour were found. In group 1 (11 patients) normal ACTH and cortisol values are present during the period of examination. In group 2 (13 patients) ACTH in increased at admission to hospital, and a decrease of the values to the normal takes place after the beginning of the infarction within 4 to 8 hours, whereas the plasma cortisol remains clearly increased. Increased ACTH and cortisol values during the whole period were measured in group 3 (6 patients). The different hormone constellations found are possibly the expression of a different reaction behaviour of the adrenocortical system in acute myocardial infarction. There is a weak positive correlation between the creatine kinase and the plasma cortisol. The size and the duration of the increase of ACTH and cortisol seems to be connected with the degree of severity of the acute myocardial infarction. An increase of ACTH and cortisol for a longer time is to be regarded as unfavourable for the course of the acute myocardial infarction, while uncomplicated courses are connected with normal ACTH and cortisol in the plasma.

Adrenocorticotropic Hormone↗
PubMed1984

Fibronectin in children with diabetes mellitus.

Fibronectin plasma concentrations were determined in 28 children with type I diabetes mellitus and 22 healthy children. No statistically significant difference was observed between the fibronectin concentrations in diabetic and non-diabetic children. Even in children with poor glycaemic control the fibronectin concentrations (glycosylated haemoglobin greater than 10%) were not significantly higher.

Adolescent↗
PubMed1983

[Characterization of the water-binding capacity of proteins].

A general method for determining the water-absorbing capacity of proteins is described. To calculate their water-absorbing capacity, the proteins are centrifuged off and then added with portions of water to determine the amount of water required for just obtaining an aqueous supernatant (in case of insoluble proteins) or for obtaining a paste which is beginning to flow (in case of soluble proteins). The correlation between the "modified centrifugation method" and the Grau-Hamm pressing method for determining the "juice loss", a method that is currently used in practice, is demonstrated by some examples.

Absorption↗
PubMed1982

[Differential hemodynamically oriented therapy in the early hospital phase of acute myocardial infarction].

100 patients with acute myocardial infarction were examined by means of catheterization of the pulmonary artery, dilution of isotopes and phonoelectrocardiography immediately after admission to the clinic and under a therapy following haemodynamic viewpoints within 2-24 hours after the beginning of the treatment, taking into consideration 15 parameters. According to a classification of the behaviour of the coronary circulation into normal function, hypovolaemia, hyperfunction, compensated insufficiency of the left heart, forward failure, retrofailure and cardiogenic shock the differential-therapeutic approach is described and the effects are explained. The haemodynamic examinations render possible the recognition of beginning circulatory complications still before their clinical manifestation, they result in founded therapeutic methods which are aimed at the correction of incorrect parameters which affect the O2-balance of the myocardium and thus the protection of the myocardium as well as the stability of the circulation, they allow a prognostic assessment of the course of the infarction and are suited to reduce the mortality of acute myocardial infarction in the early hospital phase by early recognition of developing pumping disturbances and their early treatment.

Adult↗
PubMed1981

Plasma urate measurements and fetal outcome in preeclampsia.

The relation of fetal birth weight to plasma urate concentrations and blood pressure was studied in 71 pregnant women with hypertension. The tendency to low birth weight was markedly increased when maternal plasma urate concentrations were over the normal level, generally in association with preeclampsia. Plasma urate showed a better correlation than either edema or proteinuria by itself with low fetal birth weight. Hypertension in association with elevated levels of plasma urate showed the lowest birth weight. Hyperuricemia in normotensive pregnancies showed similar fetal birth weights as maternal hypertension without other preeclamptic symptoms. These findings suggest that, in terms of fetal development, changes in renal retention of urate may be an additional predicting factor for fetal development as important as hypertension alone.

Birth Weight↗
PubMed1980

Plasma levels of prostaglandin metabolites during spontaneous delivery.

1. The fetal contribution to PGFM levels is smaller than supposed. 2. The highest levels of PGFM found at placental separation seem to indicate the decidual origin of PGs which enter the maternal organism via the open uterine veins. This assumption is supported by low levels during the postpartum period when contractions are nearly as strong as during labor, but the uterine veins are closed. 3. There is no evidence that obstetrical factors are correlated to PGFM levels.

Female↗
PubMed1980

[Radioimmunoassay of plasma cortisol and plasma cortisol circadian rhythm in external triamcinolone acetonide therapy].

Plasma cortisol levels in a four-point daily profile were measured by radioimmuno assay before and during treatment with corticoid-containing ointments (triamcinolone acetonide) in 21 patients with psoriasis, who had no endocrine disorders. In the pretreatment phase there were typical circadian fluctuations of the plasma cortisol concentrations. Already after two days of treatment a significant supression of adrenal function could be detected. This dysfunction increased during continuous treatment. In comparison with a fluorimetric method, the radioimmuno assay allowed a better differentiation. This could be due to a lack of specificity and to susceptibility to erroneous measurement of the fluorimetric method. We could also confirm that the distribution of plasma cortisol levels is not a linear but a logarithmic one. Considering the log-normal distribution different mean values and variances are obtained.

Adult↗
PubMed1979

Sudden death during doxorubicin administration.

Three patients are described who either died suddenly or had severe, life-threatening arrhythmias during or immediately after doxorubicin administration. Since doxorubicin and daunorubicin administration is known to be associated with acute EKG abnormalities, the acute decompensation in these patients appeared to be caused by the administration of these agents. The importance of careful observation of patients receiving doxorubicin, because of the possibility of acute cardiac arrhythmias, is stressed.

Arrhythmias, Cardiac↗
PubMed1979

Metabolism and pharmacokinetics of 4-(p-chlorophenylthio)butanol (W-2719) in the rat and dog.

4-(p-Chlorophenylthio)butanol (W-2719) administered orally to rats and dogs is rapidly absorbed, metabolized and excreted. The only major biotransformation product found in blood was p-chlorophenylthioacetic acid (W-2683). No W-2719 or the intermediary p-chlorophenylthiobutyric acid (W-2718) could be found in plasma after oral administration of the drug. When W-2719 was given i.v. to dogs, both W-2719 and W-2718 appeared in plasma but each had a very short half-life of about 10 min. After an oral dose of W-2719 to dogs the plasma content of W-2683 peaked at 4-6 h, amounting to approximately 20% of the dose. More than 91% of the dose was excreted with 48 h, 83% in urine and 9% in feces. The predominant excretion product in urine was p-chlorothiophenol, most of which was excreted in a conjugated form. The other major urinary metabolite was W-2683, while smaller amounts of W-2718 and unchanged drug were also found. No significant effect of prolonged dosing of 14C-W-2719 to dogs was observed on plasma 14C levels, peak time, 14C half-life or excretion and composition patterns.

Animals↗
PubMed1978

[Extraamniotic induction of abortion with a new prostaglandin E-2 derivative].

First clinical results are reported of a new prostaglandin-E2-derivative (16-phenoxy-prostaglandin-E2-methylsulfonylamide = SHB 286) as abortifacient using the extraamniotic route of application. Upon investigation in animals this prostaglandin-E2-derivative proved to be more tissue-selective and more potent in inducing abortion than the naturally occurring prostaglandins. Prostaglandin SHB 286(50 or 100 microgram) was applicated to 31 patients for legal abortion and to 7 patients with a missed abortion. The mean instillation-abortion time was 14.2 and 13.7 h respectively. 96% of the patients had a complete or incomplete abortion after 24 hours. Severe local or systemic side effects did not occur and the patients did not need any further medication.

Abortion, Induced↗