[Statistical analysis of the daily birth rate in Vienna].
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Biomedical subjects
Publications and source records attributed to E Schuster.
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Twenty-eight cases of children with deafness or severe perceptive impairment of hearing are discussed. They are selected into two groups for the symmetrical longitudinal planigraphy of the ear, the findings of which enable us to prove a labyrinthine aplasia and to compare them with audiometric findings. Accordingly we are able to draw a definite conclusion in small children. Histological findings about congenital anomalies of the inner ear with changes in the cochlea may also be divided into two groups: 1. Complete absence of development of inner ear with labyrinth aplasia. 2. Greater or lesser aplasia in the bony part of the cochlea Subgroups: (a) classic type after Mondini; (b) partial type after Mondini.
From the viewpoint of internal medicine, the author deals with risks encountered in the dental treatment of certain patients. Special attention is paid to local anaesthetics and certain risk factors such as chronic ischaemic disease, pacemaker, hypertension, and circulatory lability. Furthermore, haemorrhages are treated with special regard to haemophilia. The group of the diabetics requires consideration. The significance of endocrine diseases, allergies and vegetative disorders should not be underrated.
Serum, cord blood and amniotic fluid beta2-microglobulin contents were measured from normal pregnancies complicated by EPH gestosis, Rh immunisation and pathological serum levels of HPL and alpha1-fetoprotein. We found no changes in high risk pregnancies from normal serum levels. beta2-microglobulin seems to be no parameter in managing complicated pregnancies and fetal growth retardation.
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The findings of 300 cases of vesicoureteral reflux are reported. Girls were affected 3 times more frequently than boys. The reflux was unilateral in 61% with a strong preponderance of the left ureter. Two hundred and seven children presented with a so-called complete reflux, the contrast material being dected in the ureter and in the pelvicalyceal system at the same time. Almost one third of the children exhibited some changes of the pelvicalyceal system and every 4th patient had serious changes in the upper urinary tract and kidneys. According to the severity of the changes in the ureter, the pelvicalyceal system, and the kidney tissue, 4 types of reflux are differentiated. Typed 1 and 2 were treated successfully with conservative therapy alone, while types 3 and 4 responded only to surgical correction. In 61 cases followed closely for at least 8 months, 28 cases were cured.
The kinetics of intravenously injected [14C]cholic acid have been investigated in 14 patients with fulminant hepatic failure, 24 to 36 hr after the development of grade IV encephalopathy. Radioactivity was measured in plasma samples and in the individual plasma bile acid fractions after separation by thin layer chromatography. Plasma disappearance curves of the free [14C]cholic acid were calculated by an iterative nonlinear least squares fitting procedure using a computer. The disappearance of total plasma radioactivity was similar in all patients and greatly prolonged compared with healthy subjects. However, the plasma disappearance of free [14C]cholic acid was significantly faster in the 8 patients who recovered consciousness than in the 6 who did not. Plasma disappearance of free [14C]cholic acid correlated highly significantly with the proportion of conjugated [14C]cholate in plasma. All patients in whom more than 70% of plasma radioactivity was in the conjugated fraction 3 hr after injection survived and left hospital, whereas all of those in whom less than 55% was conjugated died. Measuring the percentage conjugation of [14C]cholate 3 hr after injection may therefore be a useful test of residual liver function in hepatic failure, as a guide to prognosis and in evaluating new forms of treatment.
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Phosphoglycerate kinase levels in Hydrogenomonas facilis were reasonably constant whether cells were utilizing or synthesizing hexose during growth. Specific enzyme activities (micromoles of 3-phosphoglycerate disappearing per minute per milligram of protein) at 30 C were 0.234, 0.391, 0.300, and 0.229 in the "soluble" fraction derived from cells grown on fructose, lactate, succinate, and glutamate, respectively. The enzyme was purified 300-fold from succinate-grown cells. The final preparation, which was not homogenous but was free from glyceraldehyde-3-phosphate dehydrogenase and adenylate kinase, had a specific activity at 30 C of 90 mumoles of 3-phosphoglycerate per min per mg of protein. K(m) values for adenosine triphosphate (ATP), 3-phosphoglycerate, and Mg(++) were 0.16, 0.83, and 0.4 mm, respectively, at pH 7.4 and 30 C. Adenosine monophosphate (AMP) inhibited 23% at a ratio of AMP to ATP of 2.4, and the possible physiological implications of this inhibition are discussed. No evidence was found for an enzyme which catalyzes ATP-dependent conversion of 3-phosphoglycerate to 1,3-diphosphoglycerate, AMP, and phosphate.
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