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Biomedical subjects

E Rossi

Publications and source records attributed to E Rossi.

At least 325 records · Page 18Linked to original sources
PubMed1983

Reversibility of lung function abnormalities in children with perennial asthma.

Extrinsic perennial bronchial asthma was studied by whole-body plethysmography in 118 patients to evaluate the degree and character of functional abnormalities during the asymptomatic "interval phase" of the disease. Study patients were divided into three functional subgroups, and the efficacy of albuterol (salbutamol), a beta-2-sympathomimetic drug, on bronchial obstruction of hyperinflation was analyzed. Response to medication was best in the group with predominant bronchial obstruction without hyperinflation. In contrast, patients with hyperinflation in the presence or absence of bronchial obstruction had only partial reversibility of their pathophysiologic alterations. Hyperinflation usually causes only minor clinical symptoms but tends to develop into irreversible lung damage in the form of "loss of elastic recoil." We suggest that early diagnosis and strict medical management in patients with hyperinflation are mandatory.

Adolescent↗
PubMed1983

Chordoma.

Explore the source record for details and available documents.

Adult↗
PubMed1983

Treatment of severe aplastic anemia with sequential immunosuppression.

Forty-two patients with severe aplastic anemia (SAA) were treated with immunosuppressive therapy (IS) consisting of one or more courses of the following regimens: a) high dose bolus 6 methylprednisolone (BMPr); b) horse antilymphocytic globulin (HALG); c) rabbit ALG (RALG); d) ALG followed by the infusion of haploidentical marrow (ALG +/- BM); e) BMPr in combination with HALG; f) ALG in combination with androgens. All patients received one initial course of IS: 16 (38%) showed hematologic reconstitution and required no further transfusions, of 26 refractory patients 4 died, and 22 received a second course of IS 60 days after the first course. Of these 22, 6 (27%) responded, and of the 16 refractory patients, 9 died, and 7 received a third course of IS 60 days after the second course. Two of these responded (28%), 3 died and 2 are alive but pancytopenic. The overall response rate is 24/42 patients (57%): all of these patients are transfusion independent 6-60 months post-treatment, and 17 are off maintenance therapy with low dose steroids. The actuarial 5 year survival is currently 60%; 13/26 surviving patients have been followed for more than 3 years. The present study confirms that over 50% of patients with SAA can recover from their aplasia following IS treatment, and this is of relevance for patients who can not be offered a bone marrow transplant.

Adolescent↗
PubMed1982

Haemolytic uraemic syndrome: therapeutic effect of plasma infusion.

The therapeutic effect of plasma infusion was evaluated in 10 children and seven adults with haemolytic uraemic syndrome. All but one patient responded to this treatment with rapid disappearance of haematological abnormalities. The patient who apparently failed to respond to plasma infusion obtained complete remission of the disease after plasmapheresis. Although 15 of the 17 patients were anuric or oliguric on admission, renal function recovered completely in eight children and two adults. Seven patients showed residual chronic renal failure and two required long-term maintenance haemodialysis. Treatment with plasma was also successful in patients with relapses or recurrent episodes. Plasma infusion is a promising therapeutic approach for the haemolytic uraemic syndrome and deserves further study in clinical trials.

Adolescent↗
PubMed1982

[Clinical forms and lung physiology changes in children with bronchial asthma].

The clinical findings, allergoimmunological results and lung function data of 208 asthmatic children (aged 4-18 years), admitted to the Pediatric Outpatient Department were investigated. In respect to the case history and the clinical findings the patients were divided into 5 etiopathogenetic groups including infectious asthma (6%), seasonal asthma (29%), exogenous perennial asthma (56%), intrinsic asthma (4%) and exercise-induced asthma (5%). All patients presented with increased airway resistance measured plethysmographically (Raw greater than 120% predicted) as indicator of bronchial hyperreactivity. On a functional basis patients with perennial asthma were subdivided into those with predominant hyperinflation (thoracic gas volume, TGV greater than 120% predicted), those with hyperinflation and airway obstruction (Raw greater than 120%), and those with airway obstruction without overinflation. By the method of circular statistics the influence of salbutamol, a beta-2-mimetic drug inhaled by pressurized aerosol, was studied to evaluate the reversibility of these functional abnormalities in the symptom free interval of disease. Response to therapy was best in the group with predominant airway obstruction without hyperinflation. In contrast, patients with airway obstruction and/or hyperinflation showed only partial reversibility of pathophysiological alterations. Hyperinflation usually causes only minor clinical symptoms but leads to the development of irreversible lung damage in the form of "loss of elastic recoil". Therefore, it is suggested that early diagnosis and strict medical management are mandatory in patients with hyperinflation.

Airway Resistance↗
PubMed1982

Persistence of circulating HBsAg/IgM complexes in acute viral hepatitis, type B: an early marker of chronic evolution.

Serial serum samples from 110 patients with acute viral hepatitis type B were tested for HBsAg/IgM complexes by a newly developed solid-phase radioimmunoassay. In 102 patients the infection resolved and they recovered from the disease. In these patients, HBsAg/IgM complexes were either absent from the outset of disappeared from serum within four weeks of admission, long before HBsAg had cleared or serum alanine aminotransferase had returned to normal, 8 patients progressed to chronic HBsAg carrier state and chronic liver disease. In these patients, HBsAg/IgM complexes were detectable in the serum on admission, and never disappeared. These results indicate that persistence of circulating complexes containing HBsAg and IgM after the early phase of acute viral hepatitis type B is a predictor of disease chronicity. As early as the fifth week of illness those in whom chronic liver disease developed could be distinguished from those who recovered.

Adolescent↗
PubMed1982

Infantile chlamydial pneumonia--a review based on 115 cases.

Clinical manifestations, diagnostic studies and management of chlamydial pneumonia were reviewed in 115 infants and compared to those from 21 infants with interstitial pertussoid eosinophilic pneumonia. The identity of these two forms of subacute afebrile pneumonia is suggested. Chlamydial pneumonia is natally acquired, essentially occurs during the second and third month of life, and its frequency in the United States is surprisingly high. Gradual onset of respiratory tract symptoms, lack of possible infection from symptomatic persons, afebrile course and staccato cough represent the typical anamnesis. Presence of conjunctivitis and serous otitis is common. Distinctive diagnostic studies include slight eosinophilia (greater than or equal to 300 eosinophils/mm3), elevated serum immunoglobulins M and G, depressed PO2 and normal PCO2 in arterial blood under room air, and both interstitial infiltrates and hyperexpansion of the lungs on chest roentgenogram. Chlamydial cultures of nasopharyngeal secretions or tracheal aspirates, and determination of antichlamydial antibody titers in serum are indicated in establishing the etiology. Adequate management consists of antichlamydial chemotherapy and general supportive care, including chest physiotherapy and oxygen and parenteral fluids when needed.

Carbon Dioxide↗