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Biomedical subjects

E Richter

Publications and source records attributed to E Richter.

At least 307 records · Page 17Linked to original sources
PubMed1979

[Intravenous and oral galactose loading of rats suffering from galactosamine hepatitis and ANIT-cholestasis; comparison of the kinetics in vivo and the galactose metabolism in the liver in vitro (author's transl)].

Different groups of rats suffering from galactosamine hepatitis or ANIT-cholestasis received 200 mg galactose either by 5 minutes intravenous infusion or via a gastric tube. Blood galactose concentrations were measured for a time period of 1.5 hrs. after intravenous administration and the galactose elimination capacity (GEC) was calculated. After oral administration the galactose blood concentrations were determined for a period of 3.5 hrs. and the oral galactose clearance was estimated. After termination of both types of galactose loading the activity of the galactokinase (EC 2.7.1.6.) was determined in total liver homogenate and compared either to the GEC or to the oral galactose clearance in vivo. Galactokinase activity in the liver increased in the group of animals with experimental cholestasis and was significantly reduced in the galactosamine treated group. In vivo these changes could be estimated much better by the GEC than by determination of the oral galactose clearance.

1-Naphthylisothiocyanate↗
PubMed1979

Sources of parathion exposures for Israeli aerial spray workers, 1977.

Exposure of Israeli agricultural spray pilots and ground crews to parathion was studied. Measurements were made with personal samplers contianing wet midget impingers; samples were analyzed by gas chromatography. Cockpit air exposure levels during 11-21-minute sampling periods for 12 flights ranged from nearly 0 to 430 microgram/m3. During sampling periods of 30 minutes to 4 hours the threshold limit value (TLV) of 100 microgram/m3 was exceeded in 2 of 19 instances. In seven measurements of ground crew exposures, TLV was not exceeded. Air washing with parathion resulted in airborne contamination of the ground level area at more than three times the TLV. Skin exposure data suggested that this route of exposure was significant for ground crew workers but not for pilots. Calculations based on the present data and standard absorption formula suggested that total daily intake for ground crew, but not for pilots, exceeded the Accepted Daily Intake (ADI) of 5 microgram/kg body weight. Sources of exposure and contamination for ground crew and pilots were identified. Recommended environmental control measures for parathion exposure should include cockpit air filtration, modification in flight patterns, paving landing areas, installation of hosing and drainage, NaOH neutralization point, and separate loading and unloading sites. Personal control measures were suggested as a supplement.

Aerosols↗
PubMed1979

Alternative transport pathways of cholephilic 14C-hexobarbital metabolites in rats with experimental hepatitis and cholestasis.

Object of the investigation was to find out whether otherwise cholephilic metabolites are excreted via an alternative pathway into urine in experimental liver disease. Intraduodenal application of 14C-labelled hexobarbital in rats is followed by an immediate biliary excretion of metabolites in the range of 400 microgram/100 g bw/h. Using TLC these metabolites can be separated into a polar fraction (about 80% of total) and a non-polar fraction. Phenobarbital treatment leads to a decrease of the total biliary excretion of metabolites to about 200 microgram/100 g bw/h, the metabolite pattern remaining unchanged. Animals with a mild form of GalN-hepatitis had a moderate reduction of bile flow and a total metabolite output of 40 microgram/100/gbw/h. The metabolite pattern showed a decrease mainly of the polar fraction. In animals with an early stage of ANIT cholestasis a 50% reduction of bile flow was associated with a total metabolite excretion of only 20 microgram/100 g bw/h and polar metabolites were nearly absent. In both types of experimental liver disease in corresponding urine samples otherwise cholephilic metabolites appeared. The results obtained show that clinically moderate stages of experimental liver disease lead to a significantly diminished output especially of polar 14C-hexobarbital-metabolites into the bile, which can, therefore, appear in the urine instead.

1-Naphthylisothiocyanate↗
PubMed1978

First clinical experiences with hormone-therapy of pachydermia laryngis.

First clinical experiences with the anti-androgenic drug cyproterone-acetate in treatment of pachydermia laryngis are reported in eleven male and female patients. This endocrine therapy led to complete healing in four and to marked improvement in six patients. One did not respond. Evaluation of the endocrine state of these patients showed imbalance in the androgen/estrogen equilibrium. As the larynx constitutes a secondary sex characteristic and an endocrine target organ, the significance of endocrine factors for pathogenesis and therapy of epithelial changes on the vocal cords is discussed.

Androgen Antagonists↗
PubMed1978

[Bioavailability of Ce-Ferro forte. Comparative iron load test (author's transl)].

The intraindividual relative bioavailability of three oral iron preparations was investigated in 9 male and 3 female healthy volunteers. After an overnight fast each of the volunteers took 110 mg Fe++ in a weak gelatine capsule soluble within the duodenum (Ce-Ferro forte) or 105 mg and 100 mg Fe++ respectively in commercial preparations. Care was taken that a 3 days interval took place between the investigations. Before taking and 1/2, 1, 2, 4, 6, 8 and 12 hrs. after taking the iron capsule, blood was withdrawn into heparinized test tubes and plasma iron concentrations were determined using an atomic absorption spectrophotometer. After taking Fe++ sulfate in a weak gelatine capsule (A), the mean plasma iron increased significantly higher in comparison to preparation B in the 2nd and in the 4th hour and in comparison to preparation C in the 1st hour. The area under curve of iron increase was 531 +/- 329 (SD) after A, 415 +/- 327 And 414 +/- 390 after B and C respectively without significant changes. From these data was concluded that Fe++ sulfate in a duodenal soluble weak gelatine capsule has a beter bioavailability than the 2 other preparations investigated.

Administration, Oral↗
PubMed1978

[Pharmacokinetics of digoxin and methyldigoxin in patients with acute hepatitis (author's transl)].

After i.v. application of 3h-digoxin or 3H-methyldigoxin to 5 healthy volunteers and 5 patients with acute hepatitis, respectively (0.75 mg daily for 3 days and 0.375 for the following 2 days) total radioactivity in urine and plasma were determined. Chloroform-soluble and -insoluble glycosides were separated and the chloroform-soluble fraction was determined by TLC. 3 days after methyldigoxin application plasma levels reached toxic values in the patient group (2.73 +/- 0.48 ng/ml), whereas in patients receiving digoxin a mean plasma level of 0.91 +/- 0.21 ng/ml was obtained. During the first 24 hours following administration of digoxin 44 +/- 12% of the dose were recovered in urine of control subjects and 48 +/- 13% in patients with acute hepatitis, after methyldigoxin 34 +/- 5% and 34 +/- 8%, respectively. Metabolism of digoxin in patients with acute hepatitis was unaltered, whereas a diminished demethylation rate of methyldigoxin could be observed. 16 patients with acute hepatitis and 7 healthy volunteers received unlabelled digoxin p.o. as maintenance dose. Plasma glycoside concentrations were studied by radioimmunoassay. The average glycoside plasma concentrations were 0.59 +/- 0.21 ng/ml and 0.63 +/- 0.24 ng/ml, respectively.

Animals↗
PubMed1978

Influence of corticosteroid on hexobarbital and tolbutamide disposition.

The influence of 10 days' prednisone treatment on the disposition of hexobarbital and tolbutamide was studied in 7 healthy male volunteers. No significant changes in the pharmacokinetic parameters of the two drugs became apparent, which indicates that prednisone pretreatment does not affect their metabolic activities.

Adult↗
PubMed1978

[Experiences with sole radiation therapy of primary osteogenic sarcomas (author's transl)].

In the course of the previous six years, nine osteogenic and three juxtacortical sarcomas have been irradiated for the single purpose of local tumor sanitation and final cure of the patient. Of nine cases with osteosarcomas, six are still alive. Two are surviving without recurrences these five years, three without metastasition. The 3-year survival amounts to 3/5. Radiation effects from high-dosage treatment are remarkably small. The cure rate after radiation therapy seems not to be inferior to the results after surgery.

Adolescent↗
PubMed1978

[Perfusion technic during clinical intra- and extracorporeal tumor removal from a solitary kidney].

On the basis of own experiences in operations of tumour-carrying kidneys two perfusion techniques for the intra- or extracorporal renal surgery are exolained and weighed one to another. In the in-situ-perfusion the pulsatile mechanical perfusion with supervisable flow, perfusate pressure and under direct measuring of temperature on organs has proved. The disadvantage of the in-situ-perfusion in contrast to the extra-corporal surgery consists in the impossibility of the local after irradiation.

Humans↗
PubMed1978

[Identification of thyroglobulin-binding cells in the blood of Hashimoto patients (author's transl)].

We developed a new method for demonstration and enumeration of antigen-binding cells, the principle and application of this method is demonstrated using peripheral blood lymphoid cells from Hashimoto patients, non-Hashimoto, non Graves' disease goiter patients and in patients without thyroid disease. A significantly higher number of thyroglobulin-binding cells was observed in the peripheral blood of Hashimoto patients as compared to members of the two other groups. The results of the FICA-tests were compared to conventional serological data of the individual patients.

Aged↗