Search PubMed⌕ Search

Biomedical subjects

E Richter

Publications and source records attributed to E Richter.

At least 325 records · Page 18Linked to original sources
PubMed1977

Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance.

Eleven patients with hepatic cirrhosis or cholestasis were treated with rifampicin for 7 to 132 days. Ten patients received hexobarbital (7.32 mg/kg) and five received tolbutamide (20 mg/kg) by i.v. infusion prior to and after rifampicin treatment; plasma concentrations of the two test compounds were determined during and after infusion. The average elimination half-life of hexobarbital had decreased from 624 to 262 min and that of tolbutamide from 292 to 160 min following rifampicin treatment. It was calculated that the metabolic clearance of hexobarbital had increased more than two-fold and that of tolbutamide almost two-fold. The results suggests that rifampicin is able to stimulate hepatic drug metabolism in patients with liver disease. It was apparent in general that the induction did not lead to improvement of hepatocellular function during disease as judged by laboratory findings.

Adult↗
PubMed1977

Anti-androgen-therapy in pachydermia of the female larynx--a new therapeutic possibility.

Case-report about a 56 year old white female patient with pachydermia laryngis and hirsutism, successfully treated with cyproterone-acetate, a testosterone antagonist. The significance of androgenic hormones for the development of epithelial changes in the female larynx is emphasized. The administration of antiandrogenic substances as a new therapeutic measure is discussed.

17-Hydroxycorticosteroids↗
PubMed1977

Influence of rifampicin on drug metabolism: differences between hexobarbital and antipyrine.

Six healthy volunteers were treated with 1,200 mg of rifampicin daily for 8 days. Before and immediately afterward each received indocyanine green, hexobarbital, galactose, and antipyrine by intravenous infusion on 3 consecutive days. The plasma concentrations of the drugs were determined several times after infusion. The average elimination half-life of hexobarbital had decreased from 407 to 171 min and its metabolic clearance had increased almost threefold. In contrast, the average elimination half-life of antipyrine was virtually the same on both occasions (6.9 and 7.2 hr) and there was no change in metabolic clearance. In a tuberculous patient treated with rifampicin the antipyrine elimination rate was unaffected. Rifampicin did not influence indocyanine green clearance or galactose elimination capacity. Serum gamma glutamyl transferase was not affected but urinary D-glucaric acid excretion was increased during rifampicin treatment. The experiment with hexobarbital was repeated after 2 weeks in all subjects; half-lives and clearance values had returned to near control values. It appears that rifampicin is a selective inducer of oxidative drug metabolism in man.

Adult↗
PubMed1977

Effect of sensory integrative therapy on the neurometer development of retarded children.

Three groups of trainable mentally retarded children participated in three different motor programs for an eight-month period. Children receiving sensory integrative therapy showed the greatest gains on test batteries for reflex integration and gross and fine motor skills. Children in a developmental physical education program demonstrated greater improvement on the same test batteries than a third group of children who participated in a recreational, adaptive physical education program and an "arts and crafts" oriented therapy program. Results of data analysis indicate that neuromotor development may be enhanced more effectively by activities which facilitate improved postural responses rather than by practice of specific motor skills.

Child↗
PubMed1977

[Adrenocortical adenoma in a 2 1/2 year old girl causing virilization and accelerated growth. Clinical and morphological results (author's transl)].

A 2 1/2 year old girl with virilization and advanced bone age was found to have a leftsided adrenocortical adenoma. The secretion of mainly androgens besides estrogens was not suppressible with dexamethasone. Plasma cortisol levels were not elevated but did not show any circadian rhythm. The tumor was localized by retroperitoneal instillation of gas, intravenous urography and tomography. After complete removal of the tumor the originally strongly elevated excretion of 17-ketosteroids sank back to normal, the acceleration of skeletal development slowed down. The right adrenal cortex was not atrophic, 2 1/2 years after the operation the child is well and without evidence of recurrent disease. Differential diagnosis as well as ultrastructor and histology of the tumor are discussed with reference to the literature.

17-Ketosteroids↗
PubMed1977

Fluoro-immuno-cytoadherence (FICA): A new method for the identification and enumeration of antigen-binding cells.

Antigen-coated particles of cross-linked dextran may be used for affinity chromatography of antibodies and for the fractionation of lymphoid cells with appropriate surface receptors. Furthermore, such particles serve as convenient substrates for quantitative immunofluorescence tests. The fluoro-immuno-cyto-adherence (FICA) is a simple technique which combines affinity chromatography and immunofluorescence, provides durable antigen-coated substrates and allows the identification, enumeration and characterization of lymphoid cells capable of binding an antigen, covalently linked via a spacer onto the surface of dextran beads. In the present study chicken thyroglobulin (TG) or bovine serum albumin (BSA) were coupled onto fluorescein and rhodamin-labelled or unlabelled Sephadex G-25 beads by means of spacer molecules. The specificity and degree of antigen-coating were controlled by indirect immunoflourescence. For the study of antigen-binding cells the different antigen-coated beads were mixed with suspensions of peripheral blood lymphoid cells from Obese strain (OS) chickens with spontaneous hereditary autoimmune thyroiditis, or with cells from BSA-immunized or unimmunized normal White Leghron chickens. Specific adherence of OS lymphocytes to TG-coated beads and of lymphocytes from BSA-immunized chickens to BSA-beads was found. The test and control preparations are observed simultaneously under the fluorescence microscope where the distinction of beads coated with different antigens can be made on the basis of the color of their fluorescence. Results obtained with the FICA technique are in good agreement with those of conventional rosette tests.

Animals↗
PubMed1977

Biochemical studies of isolated rat hepatocytes from normal and phenobarbital-treated liver as obtained by rate zonal centrifugation.

Cell suspensions from normal and phenobarbital treated livers were analysed by rate zonal centrifugation in ficoll gradients. No difference in the microsomal cytochrome P-450 and NADPH-cytochrome C reductase content and in the incorporation rate of radioactive leucine was noted between light and heavy hepatocytes. After centrifugation of a mixture of radioactive phenobarbital-treated cells and normal liver cells, the specific radioactivity was constant, indicating that the hepatocytes from drug-treated liver had the same density as the normal cells.

Animals↗
PubMed1977

[Dysontogenetic giant cyst].

Casuistics of congenital dysontogenetic giant cyst which has lead to the displacement and the restriction of the function of the two kidneys. Therapeutic experiment with repeated instillations of formaldehyde for the obliteration of cysts.

Adult↗
PubMed1977

[Metabolism of hexobarbital in patients with acute hepatitis and cirrhosis (author's transl)].

16 patients with acute hepatitis, 18 patients with cirrhosis and a total of 21 volunteers and patients with normal liver function received 7.32 mg/kg hexobarbital by linear intravenous infusion within 60 min. Hexobarbital was determined gaschromatographically in serial blood samples and the hexobarbital-clearance was calculated from the plasma concentration curve versus time. Additional experiments were performed in rats suffering from so called "galactosamine hepatitis". In half of the patients with acute hepatitis a normal hexobarbital clearance could be found. In the other patients this was distinctly reduced but not correlation was found to other liver function tests. Patients with cirrhosis were subdivided into two groups. The patients in group 1 were well compensated. The patients in group 2 had a decompensated state with ascites and oesophageal varices. In nearly all patients with cirrhosis the hexobarbital-clearance was diminished. This was more pronounced in group 2. Ketohexobarbital excretion in healthy subjects was in the range of 40-60% of dose. Patients with acute hepatitis excreted only 10-20% of dose and patients with liver cirrhosis only about 5% of dose. In rats with "galactosamine hepatitis" hexobarbital clearance in vivo was distinctly reduced and this could be explained by diminished microsomal cytochrome p 45- and hexobarbital oxidation rate.

Acute Disease↗
PubMed1977

[Hexobarbital-oxidation in vivo and in vitro in rats after phenobarbital-pretreatment or after portacaval anastomosis (author's transl)].

Male rats were pretreated with phenobarbital for 5 days or received portacaval anastomosis 3 weeks before. Hexobarbital was applicated intravenously and hexobarbital plasma concentrations were followed up gaschromatographically in arterial blood samples. Hexobarbital clearance was calculated from the plasma concentration curve versus time. Liver microsomes were prepared and cytochrome P 450 and the hexobarbital oxidation rate was determined. After portacaval shunt the animals showed a small liver, a reduced cytochrome P 450 and diminished hexobarbital oxidation rate. Hexobarbital clearance in vivo was reduced, too. After phenobarbital pretreatment liver weight increased and cytochrome P 450 and hexobarbital oxidation rate were distinctly enhanced. The hexobarbital clearance in vivo were increased. Since the plot of hexobarbital clearance in vivo versus cytochrome P 450 or versus hexobarbital oxidation rate in vitro gave a good correlation, it is concluded that hexobarbital clearance in vivo may be a good estimate for hepatic cytochrome P 450 and hepatic hexobarbital oxidation rate.

Animals↗
PubMed1976

Postmortem angiocardiography in newborn infants with congenital malformation of the heart and great vessels.

In congenital malformations of the heart and great vessels with a fatal outcome a postmortem angiocardiography may contribute to diagnosis. In this technique the heart is not dissected and the topographical relationships remain unchanged. A postmorten angiocardiography is of particular interest if no autopsy is to be performed. Some patho-anatomical details are demonstrated in three selected cases: newborn infants with 1. hypoplastic left heart syndrome, 2. truncus arteriosus communis with interruption of the aortic arch, and 3. aortic-left ventricular tunnel.

Angiocardiography↗
PubMed1976

[Hexachlorobenzene content in the whole blood of children (author's transl)].

In the spring of 1975, samples of whole blood of 98 male and 96 female children from Upper Bavaria, of 1-18 years of age, were examined for hexachlorbenzene (HCB) by gas chromatographic methods. All blood samples contained HCB ranging in concentration from 2,6 to 77,9 ppb. The HCB concentration shows a positive, hyperbolic correlation with age, tending toward a limiting value of 22 ppb for boys and 17 ppb for girls. The rate of increase in HCB concentration is inversely proportional to the square of the age. The concentration profile suggests that a substantial amount of HCB apparently starts to show up 9-10 months after birth (environmental effects?). No change in HBC concentration could be found in those children with infectious diseases. Furthermore, regional differences could not be detected, although the impression was that the HCB content was higher in children from rural areas than in children from urban areas.

Adolescent↗
PubMed1976

[Radiological anatomy of the umbilical vein, the venous duct and the portal vein in human fetuses and neonates].

Selected examples of 44 postmortem angiographies of human fetuses and neonates demonstrate the radiological anatomy of those vessels which are important for umbilical vein catheterization. The tip of an indwelling endhole umbilical venous catheter should ideally be located in the inferior vena cava directly below the right artrium of within the right atrium. A radiological control of the catheter's position is mandatory in order to avoid complications and late sequelae.

Catheterization↗