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Biomedical subjects

E Petri

Publications and source records attributed to E Petri.

At least 55 records · Page 3Linked to original sources
PubMed1982

[Palliative urinary diversion in cases of cancer of the pelvis].

The introduction of percutaneous nephrostomy under xc-ray control or ultra-sonic control makes it possible to do the operation even in patients with a bad general condition. The decision for palliative urinary diversion in cases of cancer of the pelvis is therefore largely an ethical question. A group of patients with palliative urinary diversion (n = 48) was compared to a group with iatrogenic obstruction of the urinary tracts but without recurrence of carcinoma (n = 26). Six months later only 23 of the 48 Patients in the palliative group were alive, whereas 23 of the 26 patients without recurrence of cancer were alive. After 24 months, 35 of the 48 patients with incurable cancer had died. The indications are listed.

Adult↗
PubMed1982

Deletions of specific regions of the simian sarcoma-associated virus genome are found in defective viruses and in the simian sarcoma virus.

Extrachromosomal DNA was isolated from tissue culture cells that were acutely infected with simian sarcoma virus (SSV) and its associated helper (simian sarcoma-associated virus [SSAV]). Two sizes of closed circular viral genomic DNA intermediates were isolated, cleaved at the single EcoRI site, and ligated to the Charon 21A phage lambda vector. Cloned molecules of the larger size all represented the full-length (9.0-kilobase [kb]) SSAV molecule. A heterogeneous group of clones was derived from the smaller DNA circles. These included the SSV genome and SSAV deletion mutants. When two SSV clones were compared with the helper, they contained the following three characteristic deletions: (i) a 250-base pair deletion in the gag gene about 1.0 kb from the 5' end of the genome; (ii) a 1.85-kb deletion in the pol gene; and (iii) a 1.9-kb deletion at the 3' end, which included part of the env gene. This latter deletion was the site of the onc gene substitution. Six other clones of the smaller molecules represented the following variants of the SSAV genome: (i) two clones of the entire genome containing only one long terminal repeat unit; (ii) one clone with the 1.85-kb deletion of the pol gene observed in SSSV; and (iii) three clones having a deletion of the 3' end of the SSAV genome. In each of the latter clones, the 5' border of the deletion was indistinguishable from the 5' border of the onc substitution in SSV. The fidelity of genetic deletions observed suggested that certain regions of the SSAV genome were deleted at a high frequency. In certain cases, these deletions may have been accompanied by a substitution of cellular sequences to generate SSV.

Chromosome Deletion↗
PubMed1981

Telemetric urodynamic investigations in female incontinence.

The usual method of filling cystometry fails to assess the mechanism of urinary leakage in more than half the women who complain of incontinence. Telemetric studies with televised observation provide the patient with a relative degree of privacy and thus make possible urodynamic investigations independent of restrictive laboratory conditions. Twelve women (mean age 49.8 years) underwent usual cystometric studies and subsequent telemetric urodynamic study via identical catheters and electrodes. In regular cystometry urine loss was detected in four of 12 women, while telemetric study allowed evidence of urine loss in seven of 12 women. Leakage was provoked by raised bladder pressure under various simulated stress conditions. Five non-incontinent women in the telemetric study had markedly lower bladder pressures under stress conditions than the remainder of the patients. During the voiding phase, maximum and average flow rates were increased in the telemetric study despite a slightly reduced micturition pressure and a reduced volume voided. Our discussion shows this finding to be related to lowered psychogenic stress. The introduction of telemetric techniques in urodynamics provides a further refinement of investigative methods, which may help to better understand bladder and sphincter behavior both in normal physiologic conditions and in cases of pathologic changes.

Adult↗
PubMed1980

Male stress incontinence. Diagnostic work-up and therapteutic considerations.

Urinary incontinence in 80 men was classifed by combined radiological and urodynamic techniques. 28 cases of pure stress incontinence were evaluated for grading of sphincteric loss. Clinical and sphincterometric data were correlated. Functional urethral length, urethral closure pressure at rest and with voluntary sphicter activation, and pressure transmission under stress were used to estimate the remaining sphincteric functions. Theoretical guidelines are drawn for the use of operative sphincter repair based on the grade of stress incontinence.

Adolescent↗
PubMed1980

Telemetric urodynamic investigations in normal males.

To study the applicability of telemetry in urodynamics, 10 healthy males were evaluated by both standard and telemetric urodynamic techniques. TV observation made correlation of the data with the actual situation possible. During bladder filling, intravesical pressure could be registrated in a lying, sitting and standing position. Stress conditions such as walking, running, climbing steps, kneebends, push-ups and even handstands were tested. Detrusor instability was detected with telemetric techniques in 6 volunteers, while regular cystometry showed evidence of instability in only 2 cases. Desire to void occurred in telemetric studies at lower bladder volume than in regular cystometry. A normal voiding phase was registered in all telemetric investigations, while 3/10 men displayed an abnormal micturition pattern in regular sitting cystometry. The advantages of telemetric urodynamic investigations are: (1) simulation of several stress conditions because of the patient's independence of stationary laboratory equipment; (2) lowered psychogenic stress as the patient is left undisturbed and can urinate in a normal position and (3) 24-hour investigations. It is indicated in (1) incontinence if no urine loss can be detected by regular cystometry; (2) micturition disorders in psychogenic inhibition of micturition is suspected, and (3) enuresis if 24-hour investigations are desired.

Adult↗