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Biomedical subjects

E Ott

Publications and source records attributed to E Ott.

At least 127 records · Page 7Linked to original sources
PubMed1986

Sleep alterations in ischemic stroke.

In 19 patients with cerebral infarctions in the middle cerebral artery territory, investigations of sleep using a mobile EEG recording system were performed. Sleep was found to be markedly altered compared to a normal group. Although an increase of time in bed and sleep period time was observed, total sleep time did not rise in a parallel manner, so that a distinct reduction of the sleep efficiency index was found. This increase of quantitative parameters was particularly caused by a higher amount of NREM time, whereas REM sleep was found to be deeply suppressed. Regarding the different NREM sleep stages, stage 0 (time spent awake during the night) and stage 1 had increased, whereas stage 4 was reduced. Interhemispheric differences were noticed referring to the sleep period time, which was found to be increased particularly in right-sided infarctions (because of an increase of NREM time) and a reduction of REM sleep in lesions of the right hemisphere (worsening of the REM to NREM ratio). Slow-wave sleep (stage 4), on the contrary, was found to be decreased in infarctions of the left hemisphere. These results support the hypothesis of a REM-inducing and regulating function of the right hemisphere and will lead to a new understanding of sleep-controlling mechanisms.

Adult↗
PubMed1986

[Present status of hemorheology in neurology].

Abnormalities of hemorheologic parameters are of pathophysiological importance in cases with evidence of vessel wall lesions and can thus be detected already in asymptomatic controls. Close relationships have been established to the severity of vessel wall lesions, to cerebral blood flow and to the severity of clinical symptoms.

Cerebrovascular Circulation↗
PubMed1986

[The significance of arterial hypertonia and cerebral vessel wall changes within the scope of hemorheologic changes in ischemic insult].

The frequency of vascular risk factors and of hemorheologic alterations has been investigated in 163 patients with ischaemic cerebrovascular disease and was related to angiographical findings. Hemorheologic abnormalities were observed in 57% of the patients but lesions of the cerebral vessel walls displayed by angiography were present in 85%. The leading risk factor was hypertension which was diagnosed in 42% of the patients, however, their hemorheologic profile did not differ significantly from the normotensive stroke patients. Indeed, the frequency of hypertension was significantly higher in patients with severe vessel wall lesions. The important role of hemorheologic disturbances seems to be the deterioration of the hemodynamic situation provoked by vessel wall lesions.

Adult↗
PubMed1986

[The course of hemorheologic parameters in acute cerebral ischemia].

In 74 patients with acute cerebral ischaemia determinations of hemorheologic parameters including hematocrit, red cell filtration, platelet aggregation, fibrinogen and blood viscosity were carried out and performed at first within three hours following the acute event and before treatment was started. Control measurements were performed 7, 14, 28 days and 6 months later. In the acute phase all parameters measured were significantly increased and in the following 6 months hematocrit and fibrinogen were responsible for the then still increased blood viscosity.

Acute Disease↗
PubMed1985

Evidence of enhanced platelet aggregation and platelet sensitivity in migraine patients.

In fourteen untreated migraine patients with a mean age of 40 years platelet sensitivity to 5HT, EN and ADP was investigated during the prodromal phase (three patients), 12-48 h after headache (three patients) and during the headache-free period (eight patients). Platelet sensitivity was tested using an optical density method and was calculated by the percentage of disaggregation (%DA) occurring 3 min after the peak aggregation. Platelet release reaction was assessed using beta-thromboglobulin (beta-TG) as an indicator. Platelet sensitivity to low concentrations of 5HT, EN and ADP (0.3 X 10(-9) M/ml) was most marked during the headache and prodromal phases. The least platelet sensitivity in migraineurs was detected during the headache-free interval, but was still higher than in the control group. beta-TG levels were increased during the headache phase indicating platelet release reaction. A general hyperaggregability of platelets in migraineurs has been demonstrated and in addition a varying sensibility of platelets to low concentrations of 5HT, EN and ADP has been established.

5-Hydroxytryptophan↗
PubMed1983

Rheological aspects of cerebrovascular disease.

Disturbances of the flow properties of the blood may occur in more than 40% of patients with CVD. Abnormal rheologic conditions can be measured as increased blood viscosity and may be caused by corpuscular as well as by plasmatic factors.

Blood Viscosity↗
PubMed1983

Therapeutical aspects of cerebrovascular disease.

Treatment of hemorheologic alterations in patients with CVD must be directed to reduce enhanced platelet and red cell aggregation, to improve reduced red cell deformability, and to control plasmatic hypercoagulability.

Aspirin↗
PubMed1983

Hemorheological effects of pentoxifylline on disturbed flow behavior of blood in patients with cerebrovascular insufficiency.

The influence of pentoxifylline (11-18 mg/kg orally, Trental 400) on impaired hemorheologic conditions has been investigated in a total of 73 patients with CVI. Throughout a treatment period of 4 weeks, there was a significant improvement in red cell behavior and a significant inhibition of increased platelet aggregation; moreover, a fall in plasma fibrinogen and of blood viscosity has also been observed.

Adenosine Diphosphate↗
PubMed1983

GNP effectiveness in a rehabilitation center.

Gerontological nurse practitioners have proved to be of immense value to patient care in a moderate sized (124-bed), busy (100 percent capacity), long-term care facility. A program that was established to handle a staffing problem with financial constraints has worked very well in providing extended medical services to a demanding patient load. GNPs have successfully been integrated into the facility with wide acceptance by the hospital staff and the clinic physicians to whom the facility's patients are referred when needed.

California↗