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Biomedical subjects

E Ott

Publications and source records attributed to E Ott.

At least 145 records · Page 8Linked to original sources
PubMed1981

[The effect of tiofedrine on brain perfusion in patients with cerebrovascular insufficiency].

The influence of intravenous tinofedrine (0.12 to 0.17 mg/kg body-weight) on cerebral blood flow has been investigated in 23 patients (mean age 65 years) with subacute cerebral infarction. The mean cerebral blood flow increased significantly by 20% in the infarcted hemisphere during a treatment period of 12 days. Clinically an improvement of an initially depressed vigilance level was established which was quantified psychopathometrically in 4 patients.

Aged↗
PubMed1981

Special therapeutical aspects of cerebrovascular disease.

The frequency of irreversible induced PA (IPA) by ADP or EN has been studied in 246 stroke patients. Compared to an age and sex matched control group IPA was more frequent in patients with CVD. Eighty six patients were referred to treatment of IPA with ASA or pentoxifylline or both compounds as combined treatment. ASA as well as PO were found to satisfactorily influence IPA however, the best therapeutic results have been achieved by combined treatment.

Aspirin↗
PubMed1981

The effects of haemodialysis on cerebral blood flow.

Cerebral blood flow (CBF ml/100g/min) was measured by 133Xenon in 24 patients before and after haemodialysis (HD) and in 27 normal persons. A wide scatter of the absolute CBF values were observed to correlate with the haematocrit, whereas blood pressure, pCO2 and weight loss during HD did not. Before HD, when compared with the control group, the patients showed a distinct elevation of CBF due to the severe anaemia of this group. Though there was only a slight increase in haematocrit post-dialysis a return to normal of the post-dialysis CBF was observed. In order to achieve comparative data the CBF values were corrected mathematically to a normal haemoglobin (160g/L) and the adjusted mean pre-dialysis CBF value was within the normal range and decreased to the lowest limit of normal after HD. A significant decline in CBF was observed with increasing age and length of time on HD. When compared with normal the age-dependent decline was about twice as high and showed a 10-fold decrease with the time on HD treatment. When we grouped the patients with regard to the CBF values the following results were obtained: in eight patients CBF was elevated before HD and showed a return to normal after HD. These were younger patients with greater predialysis over-hydration and lower blood pressure. A distinctly reduced CBF was observed in nine patients and remained unchanged after HD. This group included older patients with a higher blood pressure. The reaction of CBF suggests three types of patients with different vascular reactivity to fluid excess: young normotensive patients with high vascular fluid storage capacity, patients with hypertensive vascular reactivity and patients with vascular damage.

Adolescent↗
PubMed1980

Medical versus surgical treatment of patients with cerebrovascular insufficiency. A retrospective comparative study.

Report on a series of patients suffering from cerebrovascular insufficiency caused by stenosis and/or occlusion of one or several major cerebral vessels. The patients were divided in two groups, one being medically treated with anticoagulants, the other operated on either a carotid artery thrombosis by thromboendarterectomy or occlusion treated with an extracranial-intracranial arterial bypass. Results after a follow-up period of 1-3 years are compared and discussed in view of the recent literature.

Adult↗
PubMed1979

Disturbances of the coagulatory system in patients with severe cerebral trauma II. Platelet function.

Platelet number, spontaneous aggregation, ADP- and adrenaline-induced aggregation, fibrinogen, and factors 2, 5, 7, and 10, were investigated in a series of 40 consecutive patients admitted to the clinic following severe head injury. Data were evaluated daily during the first week after trauma. Platelets were significantly decreased, particularly in non-survivors; there was no pathological spontaneous aggregation, except in a group of 22.5% of cases who had a mean age of 23.5 years. ADP-induced aggregation was negative in 69% of cases, and adrenaline-induced aggregation was absent in only two non-survivors. Fibrinogen was markedly reduced during the first five days, thereafter normalizing or increasing towards the end of the week. The other investigated values remained within their normal range of 70--130%. The results give no evidence of disseminated intravascular coagulation as a generalized and frequent phenomenon in severely head injured patients. There are, however, signs of latent consumption coagulopathy, which support data from the literature that indicate focal microthrombosis in contused brain areas.

Adenosine Diphosphate↗
PubMed1978

[The influence of tinofedrine on fibrinogen and platelet aggregation in patients with recent cerebral infarction (author's transl)].

The influence of Tinofedrine (0.12--0.17 mg/kg. bodyweight) on fibrinogen and platelet aggregation has been investigated in 45 patients (mean age 65 years) with recent cerebral infarction. Depending on the duration of medication a significant decrease of the fibrinogen level as well as of enhanced platelet aggregation has been observed. It is concluded from the present results that the decrease of enhanced platelet aggregation may be mediated by the fall of fibrinogen.

Aged↗
PubMed1978

Preoperative propranolol therapy and aortocoronary bypass operation.

The relationship between long-term propranolol hydrochloride therapy and subsequent coronary bypass operation was prospectively investigated in 119 patients who were grouped three ways: propranolol therapy continued in full dosage to operation (group A), propranolol therapy discontinued or tapered 24 to 72 hours preoperatively (group B), and no preoperative propranolol therapy (control group). During preoperative hospitalization, one patient in each group A and the control group suffered an increase in anginal symptoms compared with 15 patients in group B, three of whom also had new ventricular arrhythmias. During anesthesia up to the period of cardiopulmonary bypass, 26% of group A patients showed signs of ischemia (eg, ST segment deviation or ventricular arrhythmias) as compared with 51% of the control group and 70% of group B. Hypotension and bradycardia were not more common in group A patients. No differences among groups were noted in case of emergence from bypass, need for cardiac stimulants, or mortality.

Anesthetics↗
PubMed1978

[Clinical diagnosis of normal pressure hydrocephalus (author's transl)].

5 patients are described in which normal pressure hydrocephalus was diagnosed. The criteria on which the diagnosis was based were a cerebrospinal fluid perfusion test and an air study. Pathological verification was additionally obtained in 2 patients. The clinical picture in all patients was characterized by dementia. 4 patients were incontinent and 3 were paraspastic.

Adult↗