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Biomedical subjects

E Nagy

Publications and source records attributed to E Nagy.

At least 307 records · Page 17Linked to original sources
PubMed1982

Anthrax-specific "AP 50-like" phages isolated from Bacillus cereus strains.

Phages exerting a specific action on Bacillus anthracis were isolated from mitomycin C-induced concentrated lysates of 5 Bacillus cereus strains producing megacin A (phospholipase A). In electron micrographs the phages closely resembled the anthrax-specific, lipid containing phage AP 50 isolated earlier from soil sample. The phages were similar to AP 50 also in their antigenic and chemical structure, host range and sensitivity to organic solvents, detergents and caesium chloride. The DNA character of AP 50 nucleic acid was shown by agarose gel electrophoresis. AP 50 and related phages seem to represent a separate group of phages acting on Bacillus strains.

Bacillus anthracis↗
PubMed1981

Five different adenomas derived from the rat adenohypophysis: immunocytochemical and ultrastructural study.

With the use of electron microscopic morphology and immunochemistry, 5 tumors were studied: a spontaneous prolactin-producing adenoma (LEP rats); an estrogen-induced intrasellar tumor (R-Amsterdam rats); and 3 transplanted tumors, MtT.W10 and MtT.W5 (WF rats) and MtT.F4 (F344 rats). All tumors were derived from rat adenohypophysis and are known to secrete prolactin, growth hormone, or adrenocorticotropic hormone. The spontaneous tumor consisted of a uniform population of cells containing only immunoreactive prolactin. In the estrogen-induced tumor, prolactin and growth hormone were localized in separate cell types with the use of the immunoperoxidase technique. In the MtT.W10 tumor, both immunoreactive prolactin and growth hormone were observed in the same cell and in separate cell types. In the MtT.F4 and MtT.W5 tumors, one cell type was identified that was characterized by lack of morphologic differentiation, reduced secretory granule number, and inconclusive immunopositivity.

Adenoma↗
PubMed1981

Prolactin and contact sensitivity.

Hypophysectomized (Hypo-X) rats did not develop contact dermatitis in response to dinitrochlorobenzene (DNCB). Syngeneic pituitary grafts placed under the kidney capsule or daily treatment with prolactin restored the DNCB-reactivity of Hypo-X animals. Combined treatment with other pituitary hormones was ineffective. Treatment of normal rats with a potent prolactin antagonist drug, bromocriptine, was as effective in inhibiting contact sensitivity as was hypophysectomy. These results indicate the contact sensitivity is a prolactin dependent reaction.

Animals↗
PubMed1981

Regulation of humoral immunity in rats by pituitary hormones.

Hypophysectomized female Fischer 344 and Wistar-Furth rats had severely impaired primary and secondary antibody responses to sheep red blood cells (SRBC). Mercaptoethanol-sensitive (IgM) and mercaptoethanol-resistant (IgG) antibodies were similarly affected. Titers to E. Coli 055:B5 lipopolysaccharide were also significantly decreased in such animals. The antibody response of hypophysectomized rats could be restored by syngeneic pituitary grafts when placed under the kidney capsule or by prolactin treatment. Growth hormone was less effective in this respect than prolactin. Treatment of normal rats with ACTH suppressed their antibody formation to SRBC. These results indicate that the pituitary gland has the potential to regulate humoral immune responses.

Adrenocorticotropic Hormone↗
PubMed1981

[Recent data in the diagnosis of scaphoid non-union (author's transl)].

An analysis of the problems of the scaphoid non-union diagnostics is given here, based on their experiences with more than 400 operations. Bennet's x-rays are always mandatory, and if problems arise, microfocal x-rays and tomography should be done. They draw the attention to certain x-rays signs described by them. Intraosseous venography has been introduced to help the diagnosis. The distinctive signs between bipartite scaphoid and scaphoid non-union are given too.

Carpal Bones↗
PubMed1981

Histiocytosis X with unusual skin symptoms.

A 4-year-old boy with skin symptoms resembling verruca plana juvenile was observed. The light- and electron-microscopic picture showed the typical features of histiocytosis X (Letterer-Siwe syndrome). Beside the skin manifestations some less dense areas in the skull bones were found by X-ray examination. Vinblastine and prednisolone treatment for one year resulted in complete remission.

Child, Preschool↗
PubMed1980

[Combination therapy of porphyria cutanea tarda using chloroquine and bloodletting therapy].

14 patients with PCT were treated with phlebotomy combined with Chloroquine. 4 venesections were performed before Chloroquine-treatment administered intermittently twice weekly. The so-called flu-syndrome manifested itself in the majority of patients. The clinical symptoms of PCT regressed within 6 weeks to 4 months of treatment, and the urinary uroporphyrin excretion returned to normal within 6 weeks to 3 months. Besides the flu-syndrome no side-effects could be observed. There has been a clinical and biochemical remission for a year and a half in each case but one. Relapse occurred in one case only one year after treatment.

Adult↗
PubMed1980

The diagnostic role of the intraosseous phlebography in the affections of the hip in childhood.

The authors have applied intraosseous phlebography 38 times in 33 children, in order to assess the extent of damage to the femoral head circulation in fractures of the femoral neck and other disorders. Contrast medium was injected mostly into the epiphysis, but eventually into the metaphysis too. Results of these examinations have been important guidelines in the management of the disease, i.e. if the venous drainage of the contrast medium was delayed or absent, or if the contrast medium was congested in the head, the weightbearing had to be releaved until regenerative signs of the femoral head were seen.

Adolescent↗