Peritoneal lavage red blood cell and white blood cell count: a prospective comparison of usefulness.
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Biomedical subjects
Publications and source records attributed to E Meyer.
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In seven patients with orbital lesions, fine-needle aspiration (FNA) was performed. No complications were seen in performing this procedure. FNA proved to be an important adjuvant method in the diagnosis of orbital lesions, especially in their pre-operative cytologic definition.
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A one year old female infant with mental and motor retardation and bilateral optic atrophy in association with pericentric inversion of chromosome No. 2 is described.
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In 35 patients at the age between 20 and 45 years with a manifest coronary heart disease various lipid-chemical parameters were established and compared with a control group of the same age of laboratory-chemically and clinically inconspicuous test persons as well as with a group of patients with infarction older than 45 years. For HDL-cholesterol, LDL-cholesterol as well as LDL significant differences of the mean value were the result in the group of juvenile patients with a coronary heart disease and in the healthy control group as well as the group of older test persons with infarction, which confirm the accumulation of lipid-chemical risk constellations in "juvenile" patient with a coronary heart disease. Moreover, the proportion of primary hyperlipoproteinaemias is essentially greater in these patients than in older test persons with infarction. Apart from the recognition of primary hypercholesterolaemias the diagnostics of autosomally combined hyperlipoproteinaemias is of particular importance.
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In 23 consecutive patients with Cushing's disease and 52 control subjects, the responses of ACTH and cortisol to TRH and LRH were investigated. From the pattern of cortisol levels after the administration of the releasing hormone in the controls, a criterion for paradoxical responsiveness could be derived (maximum cortisol increase, greater than 6.0 micrograms/100 ml). According to this criterion, 9 patients with Cushing's disease showed a paradoxical responsiveness to one or both releasing hormones (3 to both TRH and LRH, 3 to TRH alone, and 3 to LRH alone; group I). In all patients tested, paradoxical responses of cortisol were preceded by paradoxical increments in ACTH. The remaining 15 patients showed no paradoxical increments in ACTH or cortisol after TRH or LRH (group II). ACTH levels in group I (89 +/- 28 pg/ml) were significantly lower than those in group II (185 +/- 164 pg/ml; P less than 0.02). Nevertheless, in both groups, a similar plasma cortisol level was found, suggesting a relatively higher bioactivity of ACTH in group I. A second difference between both groups was a lower amplitude of cortisol variability during the day in group I. The 2 groups did not differ in clinical data, such as age, sex distribution, sellar volume, and duration of disease, or dexamethasone suppressibility, bromocriptine sensitivity, and basal PRL levels. These latter findings do not favor an intermediate lobe origin of Cushing's disease in patients with paradoxical responses to TRH/LRH. To conclude, TRH/LRH responsiveness of ACTH/cortisol discloses two subsets of patients with Cushing's disease.
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