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Biomedical subjects

E Lang

Publications and source records attributed to E Lang.

At least 163 records · Page 9Linked to original sources
PubMed1984

[Arndt-Gottron scleromyxedema and associated phenomena].

Scleromyxedema is an uncommon fibromucinous connective tissue disease characterized by accumulation of mucinous material in the dermis. A monoclonal paraprotein is regularly identified. A review of the literature (57 cases) shows the exceptional association of scleromyxedema with multiple myeloma (8.7%) and macroglobulinemia Waldenström (3.5%). A man with scleromyxedema, IgG lambda paraproteinemia, and sclerodactylia--as a special sign of scleromyxedema--is reported. Melphalan is the drug of choice in serious cases, but not effective in sclerodactylia.

Fingers↗
PubMed1983

[Anticoagulants and thrombocyte aggregation inhibitors in the treatment of heart infarct. A survey].

The treatment of causes and complications of myocardial infarction is complicated by variable response to anticoagulants and inhibitors of platelet aggregation. No generally accepted principle for treatment of myocardial infarction is available at present. Following a literature review and after our own experience we suggest an immediate treatment of acute myocardial infarction with heparin and a switch to oral anticoagulants after heparin treatment of the acute phase. Three to four weeks after the acute myocardial infarction invasive diagnostic procedure should be performed. The result will lead to a decision about possibly extended therapy with oral anticoagulants. Left ventricular aneurysma e.g. would lead to prolonged coumarin-therapy. If no oral anticoagulants are necessary long term treatment with sulfinpyrazone or Aspirin plus dipyridamole should be initiated.

Anti-Inflammatory Agents↗
PubMed1983

[Severe generalized atherosclerosis in a 14-year-old boy].

A case of severe generalized atherosclerosis in a 14-year-old boy is reported; all the large arteries, including the coronary vessels, were involved. A high degree of stenosis of the abdominal aorta very close to the origin of the renal arteries was thought to be the reason for the accompanying considerable systemic hypertension. Laboratory investigations were not able to produce evidence of the cause of the disease, and there were no apparent risk factors. Finally, it was concluded on the basis of the family history of the patient that a genetic component involving unknown pathogenetic mechanisms was responsible for the early manifestation of the disease.

Adolescent↗
PubMed1982

Abrupt withdrawal of pindolol or metoprolol after chronic therapy.

1 In an open controlled study a group of 18 healthy volunteers received either pindolol 10 mg three times daily or metoprolol 100 mg three times daily for 4 weeks. Before treatment, and after abrupt withdrawal the resting heart rate, the blood pressure, the exercise heart rate and the isoprenaline CD25 (dose of isoprenaline to increase the heart rate of 25 beats/min) were determined. Heart rates were continuously monitored by an ECG-coupled computer. The CD25 values were calculated by an off line computer procedure from the on line recorded data. 2 After metoprolol we found 6 out of 12 patients with a CD25 below baseline, in one case with a corresponding increase in heart rate during exercise. After pindolol we observed a CD25 below baseline only in one case with no corresponding reaction in the exercise test. In both groups we observed a reactive increase in resting heart rate and systolic blood pressure around day 5 after withdrawal. 3 We conclude that abrupt withdrawal of metoprolol in contrast to pindolol is associated with a higher risk of developing beta-adrenergic receptor hypersensitivity.

Adult↗
PubMed1982

Endotoxaemia and complement activation in acute pancreatitis in man.

Twenty-four patients who experienced 26 attacks of acute pancreatitis were studied. Endotoxaemia, as measured by the limulus lysate assay, was present in 13 of the attacks. Six out of seven patients with systemic complications of the disease had endotoxaemia. C3 catabolism was increased in all 26 attacks of pancreatitis, and a falling level of C3 during attacks of severe pancreatitis was associated with a fatal outcome. There was statistical evidence of more complement activation in serum samples taken when patients had positive limulus lysate tests than when endotoxin was not detected in their blood.

Acute Disease↗
PubMed1982

[The strain of physiotherapeutical treatment in elderly patients (author's transl)].

The strain of physiotherapeutical treatment in elderly patients depends on their age, their disease and on the type of the physiotherapy chosen. A survey carried out on 296 patients primarily suffering from heart circulation disease in the preclinical and clinical stage has shown that in case of elderly patients one generally must reckon with a latent heart and circulation disease. The risk of complications arising as result of the physiotherapy with respect to the heart and circulation system can be reduced by a thorough diagnosis. The relative intensity of the exercise employed should be on the low side. The risk particularly rises if the performance exceeds 80% of the maximal physical endurability involving the ergometer and gymnastical training with an average increase of the heart frequency over 120/min., swimming in cool water, balneotherapy in the full bath and exercises using mainly extensive isometrical actions.

Age Factors↗
PubMed1982

[Stroke volume and cardiac output equivalents under orthostatic load in young and elderly volunteers (author's transl)].

With advancing age, orthostatic disturbances of regulation become clinically more relevant. They are observed in about 25% of persons older than 65 years, independent of their initial blood pressure. The stroke volume equivalents obtained by means of impedance cardiography enable the physician to differentiate between the behaviour during the early regulation phase and that during the phase of late regulation. The following conclusions can be drawn from the findings in 38 young volunteers (average age: 22 years) and 39 elderly volunteers (average age: 76 years): In elderly volunteers with normal late regulation, the stroke volume drops immediately by 16.1 ml and attains a maximum drop by 19.5 ml after ten minutes. Elderly volunteers with pathologic late regulation show a distinctly higher decrease in stroke volume by 38 to 42 ml below the initial level. With younger volunteers with normal late regulation, the stroke volume drops after positional change by 43 ml and attains an average minimum value of 55 ml after ten minutes. With the younger volunteers with pathologic late regulation, there is an average drop by 52.7 to max. 72.7 ml below the initial level. Assessment of the immediate regulation shows 2 different types of behaviour of orthostatic immediate regulation.

Adult↗
PubMed1982

[Relations between acanthosis nigricans benigna and pseudoacanthosis nigricans].

A 37-year-old man is reported who, as a schoolboy and during puberty, showed the clinical aspects of acanthosis nigricans benigna. In correlation with an obvious obesity the picture has meanwhile developed into pseudoacanthosis nigricans. On the basis of this case the delimitating criteria of the various acanthosis nigricans subgroups and their etiologic factors are discussed.

Acanthosis Nigricans↗
PubMed1981

Beta-receptor blocking therapy in hypertensive patients--effects on vigilance and behaviour.

In 13 hypertensive patients taking the beta-receptor blocker atenolol, EEG and behaviour effects were studied. Using a single-blind sequential trial design, a 5-d placebo period was followed by a 6-d atenolol treatment period (100 mg/d). During either treatment period, two examinations yielded data derived from neurophysiological, test-psychological, and cardiovascular measurements. The statistically significant changes due to atenolol therapy indicated an improvement of vigilance, a smooth anxiolytic and tranquilizing effect, and at least no negative influences on discriminatory reaction time and concentration ability. The primary therapeutic effects were significant falls in systolic and diastolic blood pressure as well as in pulse rates. The study is still in progress and will be completed after 20 patients are reached. The data will then be reanalyzed in order to get further insight into CNS effects of a beta-blocking therapy concerning favorable vs. poor drug responders.

Adrenergic beta-Antagonists↗
PubMed1981

Hemodynamic effects of single-dose administration of AR-L 115 BS in patients with coronary artery disease.

2-[(2-Methoxy-4-methylsulfinyl)phenyl]-1H-imidazo[4,5-b]pyridine (AR-L 115 BS) was investigated in 14 patients with coronary artery disease (CAD) and an elevated left ventricular enddiastolic pressure at rest (LVEDP). There was a significant decrease in the systolic (AOPS) and diastolic aortic pressures (AOPD) of 9% and 6%, respectively, (p less than 0.001, p less than 0.01). The LVEDP decreased by 29% (p less than 0.001), and the maximum rate of pressure rise (dp/dt max) increased by 19% (p less 0.001). The systolic (PAPS) and diastolic pulmonary artery pressures (PAPD) fell by 17% and 16%, respectively (p less than 0.05). The cardiac index (CI) increased by 12% (p less than 0.05), and the peripheral resistance (SVR) fell by 17% (p less than 0.001). Heart rate increased slightly by 5% (p less than 0.1) but this was of no clinical relevance. The right atrial pressure (RAP) and the tension time index (TTI) remained unchanged. AR-L 15 BS was observed to have vasodilating and positive inotropic effects without increasing oxygen consumption. It can therefore be recommended for use in patients with CAD and an elevated LVEDP. Side-effects have not been reported.

Adult↗