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Biomedical subjects

E Lang

Publications and source records attributed to E Lang.

At least 181 records · Page 10Linked to original sources
PubMed1981

Haemodynamic effects of amezinium in man.

After single i.v. (5 and 10 mg) and p.o. (10, 20 and 40 mg) administrations, 4-amino-6-methyoxy-1-phenyl-pyridazinium methyl sulfate (ameziniummetilsulfate, LU 1631, Regulton), in the following briefly called amezinium, a new antihypotensive agent, was studied by non-invasive methods for its cardiovascular action in comparison with norfenefrine (10 mg i.m. and 40 mg p.o.) and dihydroergotamine (1 mg i.m. and 4 mg p.o.) in a group of 33 volunteers. The action pattern of 10 mg amezinium i.v. consisted of a significant rise in arterial blood pressure (systolic 23%, diastolic 14%) with an increase in pulse pressure (38%) and a reflex fall in heart rate (9%). The total peripheral resistance was increased by 29%, with a moderate reduction of cardiac output (5%; n.s.) and an increase of the stroke volume (6%; n.s.). A clear positive inotropic effect was discernible by the significant reduction of heart rate, corrected preejection period (delta PEP; 13 ms), left ventricular ejection time (delta LVET; 8 ms; n.s.) and a decrease of the ratio PEP/LVET (-0.028). This pattern of action points to stimulation of vascular alpha- as well as cardiac beta 1-adrenoceptors and is in accordance with the findings from animal experiments as amezinium acts via endogenous noradrenaline. The reference substance norfenefrine exhibited purely alpha-sympathomimetic action, whereas dihydroergotamine presumably exerted venoconstrictive and central sympatholytic effects. The effects of amezinium after p.o. administration on the circulation were similar to those after i.v. administration, whereas the reference substances did not reveal any definite pharmacodynamic action when given p.o. Single administrations of the various p.o. doses of amezinium gave rise to a dose-dependent increase of the systolic blood pressure, persisting over the 180 min of the investigation period. From the dose-response relationships after parenteral and oral administration a relative enteral efficacy of 50-80% was established, which corresponds well with bioavailability data. The results show amezinium to have potent, long-lasting blood pressure increasing and positive inotropic actions in man after oral as well as parenteral administration.

2-Hydroxyphenethylamine↗
PubMed1981

Cardiovascular effects of amezinium in humans during passive upright tilt in comparison with norfenefrine and dihydroergotamine.

20 min after single i.v. administration of 10 mg 4-amino-6-methoxy-1-phenyl-pyridazinium methyl sulfate (ameziniummetilsulfate, LU 1631, Regulton), in the following briefly called amezinium, a new antihypotensive agent, was studied in comparison with 10 mg norfenefrine i.m. and 1 mg dihydroergotamine i.m. during orthostatic stress on a tilt table in a total group of 29 healthy volunteers with stable cardiovascular conditions. The study of each substance was preceded by a control tilting test. After amezinium a higher systolic blood pressure of 10 to 15 mmHg in comparison with the control test was maintained during 5 min upright tilt with both a smaller increase in the rise of heart rate and decrease in stroke volume. In comparison with control, pulse pressure was also clearly increased whereas cardiac output and total peripheral resistance were not significantly different. The increase in stroke volume in comparison with control was a result of the positive inotropic effect on the one hand, which could be seen in both a diminished prolongation of the preejection period and increase in the PEP/LVET ratio, and an increased venous return to the heart on the other hand. Systolic blood pressure and heart rate after norfenefrine were principally similar to those after amezinium, whereas the effect on stroke volume was of minor magnitude because of the absence of a positive inotropic action. Moreover, cardiac output decreased more with higher total peripheral resistance in comparison to control. Besides a slight reduction in heart rate, dihydroergotamine did not reveal any significant differences from control during orthostatic stress. At the dose studied, amezinium seemed to produce a better adaptation to passive upright tilt than the reference substances.

2-Hydroxyphenethylamine↗
PubMed1981

[Speech audiometry in advanced age - differentiating between the elements of primary and secondary presbyacusis (author's transl)].

Tone threshold, speech intelligibility by the Freiburg test with loss of hearing for speech, discrimination loss and total word intelligibility, dichotic discrimination and binaural summation ability were all measured in 167 test subjects aged between 65 and 91 years. The statistical processing of the numerous parameters shows that all parameters manifest a worsening of hearing with age, the individual values revealing a considerable scatter. Tone loss proved to be largely cochlear in nature. All the speech audiometric parameters correlated highly significantly (binaural summation significantly) with age, in the sense that increasing was accompanied by a worsening of the hearing ability. The complex correlations among all the hearing parameters lead us to believe that ageing affects the organ of hearing as a whole, and not merely specific parts of the auditory pathway. A possibility for differentiating between the elements of primary and secondary presbyacusis, and for measurement of the biological age of the sense organ, ear, is discussed.

Age Factors↗
PubMed1981

[Preclinical precautions in the therapeutic treatment of the aged].

In the case of elderly subjects in the preclinical stage of an illness, medication is required in exceptional cases only. On the other hand, general therapeutic aspects should be considered as early as possible in connection with a chronic illness accompanying the ageing process. In the elderly, physiotherapy forms a by no means insubstantial part of treatment. Considerable evidence points to its value during the preclinical phase. When physiotherapy is indicated, it is, however, important to avoid any danger of the therapeutic measures exceeding the maximum stress which such an elderly patient is able to bear. The stress imposed on the patient should be set at an appropriately low level, so as to avoid serious complications wherever possible. The following activities have been found to be particularly prone to complications: a load of more than 80% of the maximum functional capacity in ergometric training; gymnastic exercises producing an average rise in pulse frequency to over 120/min.; swimming at relatively low water temperatures and balneotherapeutic treatment in a full-size bath.

Aged↗
PubMed1981

[Risks of physiotherapeutical intervention in pre-clinical geriatrics (author's transl)].

Physiotherapeutical measures of intervention applied to ageing people must not be regarded as a form of neutral secondary treatment included in a therapeutical concept. A wealth of positive findings illustrates that physiotherapeutical measures can be regarded as a meaningful possibility of influencing the ageing process, and in particular the diseases accompanying the ageing process, in a positive way. This is demonstrated by the behaviour of various data recorded for the cardiovascular system, the pulmonary function and the maximum oxygen absorption capacity, all of which being indicators of physical fitness. In people of advanced age all these data are also clearly improved by physiotherapeutical intervention. The positive effects of physiotherapeutical measures can be enhanced by taking into account the risks which may occur in ageing people whose tolerance to stress has been exceeded.

Aged↗
PubMed1980

[The effect of treatment on performance and self-appraisal in geriatric patients (author's transl)].

On the background of the wellknown favorable effects on the social behavior, mood and activation, a six-week treatment with Hydergin of 34 inhabitants of an old people's home led to a significant improvement in the results of psychometric performance tests and to a realistic self-appraisal with consequent greater adaptation. Hydergin was thus shown to be distinctly superior in its observed favorable therapeutic effects to chlordiazepoxide which sometimes rather intensifies the unrealistic self-appraisal of people living in old people's homes.

Aged↗
PubMed1980

[On the platelet aggregation inhibiting and analgesic activities of acetylsalicylic acid (author's transl)].

Acetylsalicylic acid (ASA)--now the most potent platelet-aggregation inhibitor--is being investigated in combination with glycine (Godamed; text preparation A) and microencapsulated (test preparation B) in view of the plasma total salicylate level and platelet aggregation inhibiting effect. The examination is conducted on 20 patients by the cross-over method. An increase of the plasma total salicylate level of test preparation A compared with test preparation B is highly significant up to 60 min after application of 1000 mg ASA respectively. As in shorter time a higher plasma total salicylate level is reached a significantly higher analgesic effect of the test preparation A may be expected. In certain indications, occurring with pain, as for instance arterial occlusive disease, thrombophlebitis, etc., this is absolutely desired. Additional application of analgetics is then often unnecessary. A differentiated use of ASA preparations as platelet-aggregation inhibitors is therefore required. To investigate the disaggregating effect of both ASA preparations the PAT-III test by Breddin was used. 2 h after the oral application of 1000 mg ASA a complete normalisation by both ASA preparations was reached, whereas before a significant higher platelet aggregation had been recognized. The somewhat faster reached effect of test preparation A is not significant and clinically not relevant. When in the acute phase as well as in the long-term treatment of the above mentioned indications an ASA-containing platelet-aggregation inhibitor is used, that preparation should get preference which is well tolerable and has the same platelet-disaggregating effect but with the higher analgesic effect.

Analgesics↗
PubMed1980

[Antibiotic treatment in hand surgery of childhood (author's transl)].

The use of antibiotics in hand surgery in children must be guided by the same critical indications which apply to antibiotic therapy in general, and bacterial sensitivity to antibiotics must be considered in each case. In potentially infected patients, intra- or perioperative prophylactic antibiotic may be used and the dangers of widespread uncritical use of antibiotics is pointed out.

Anti-Bacterial Agents↗
PubMed1979

[Beta-blockader, pindolol, in the therapy of angina pectoris; a report on a multicentric controlled study].

68 patients with angina pectoris were treated 14 days with placebo and four weeks with 15 mg/die pindolol (Visken) in a double blind multicenter study. The patients were divided into two groups at random: group I received pindolol/placebo, group II pacebo/pindolol. Pindolol reduced in both groups significantly the number and intensity of angina pectoris attacks and the consumption of nitroglycerin capsules. There was no evidence for a rebound phenomenon after abrupt cessation of pindolol treatment. In the wash out period still a relevant antianginous effect of the beta-blocker could be observed. The oxygen demand of the myocardium was reduced by reduction of systolic blood pressure and heart rate whereas diastolic blood pressure remained unchanged. The tolerance of the preparation was good.

Angina Pectoris↗
PubMed1979

[Examinations of the pulmonary function of untrained and physically trained old men (author's transl)].

In tests there were determined the vital capacity and absolute and relative seconds capacity of 180 physical-trained sportsmen aged 55 to 89 and of 175 untrained, but clinically healthy test persons. The results of the different age-intervals are compared statistically. It was noticed, that vital capacity and absolute seconds-capacity of both groups decrease statistically significant with the age. Vital capacity and seconds capacity are in all age-intervals on a higher level with the trained sportsmen than the control group. The relative seconds-capacity showed no significant difference between the two groups. There is a clear statistic connexion between the vital capacity and the time obtained in a 5 000 meters run. One can suppose that in contrast to juvenile sportsmen a good pulmonary function is a contributory determinant of the performance of old sportsmen.

Age Factors↗
PubMed1978

Enzyme changes after coronary angiography.

The enzymatic response to contrast media after coronary angiography was observed in 24 patients. The enzymes studied were glutamic oxaloacetic transaminase (SGOT), glutamic pyruvic transaminase (SGPT), lactic dehydrogenase (LDH), alpha-hydroxybutyrate dehydrogenase (alpha-HBDH), gamma-glutamyl transferase (gamma-GT), creatine phosphokinase (CPK), and the myocardial-specific isoenzyme of CPK (CK-MB). Angiography produced no significant elevations in SGOT, SGPT, alpha-HBDH, LDH, or CK-MB activities; gamma-GT increased up to the twelfth hour. High levels of CPK and CK-MB observed in one patient were found to be products of a thymus carcinoma. In vitro examinations also showed that concentrations of contrast media used in coronary angiography do not inhibit gamma-GT, LDH, and CPK activities.

Adult↗