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Biomedical subjects

E Kucharz

Publications and source records attributed to E Kucharz.

At least 73 records · Page 4Linked to original sources
PubMed1977

The effect of cytostatic drugs on collagen metabolism in guinea pigs.

Azathiprine (0.25 mg/100 g body wt.) and cyclophosphamide (0.2 mg/100 g body wt.) were administered to guinea pigs, orally every day during 4 weeks. Azathioprine caused a decrease in total collagen content in skin, liver and bone and decreased hydroxyproline and hydroxylysine concentration in blood serum, and urinary excretion of collagen catabolites. No effect of cyclophosphamide on total collagen in skin and liver was observed. An increase in collagen content in bone in cyclophosphamide-treated guinea pigs was found. A decrease of hydroxyproline and hydroxylysine in blood serum and urine was observed after cyclophosphamide treatment. The results support the view that cytostatic drugs inhibit collagen metabolism, and azathioprine significantly affects collagen biosynthesis, and cyclophosphamide influences inhibition of catabolic processes of collagen.

Animals↗
PubMed1976

Effect of chronic exposure to nitrogen dioxide on collagen fractions content in skin of guinea pigs.

Guinea pigs were exposed to nitrogen dioxide in concentration of 2 mg/m3 (8 hrs. daily, 180 days). Control group inspired fresh air. Collagen fractions were estimated in skin and assayed as hydroxyproline concentration. An increase of total collagen content, due to on increase of salt-soluble collagen fraction was found in the skin of the exposed animals, while a simultaneous decrease of insoluble collagen content was observed.

Animals↗
PubMed1976

Serum glycoproteins level and urinary glycosaminoglycans excretion in drug induced collagen-like syndrome in guinea pigs.

A collagen-like syndrome was produced by a long-term administration of 1-hydrazinophthalazine (hydralazine) to guinea pigs. The results obtained indicate that hydralazine-induced collagen-like syndrome stimulated an increase of the concentration of perchloric acid-soluble proteins, protein-bound hexoses, protein-bound-hexosamines and sialic acids in blood serum as well as urinary excretion of glycosaminoglycans. The increase of serum glycoproteins is not connected with non-specific changes in total protein level. No biochemical differences were found in the parameters studied between subgroups (LE-positive and LE-negative) of hydralazine treated animals.

Animals↗