Biomedical subjects
E Heilmann
Publications and source records attributed to E Heilmann.
[Extracoporeal irradiation of blood in the treatment of leukemia. Experiences on 25 patients with chronic lymphadenosis].
Extracorporeal irradiation of the blood (ECIB) is a valuable addition to the treatment of chronic lymphatic leukemia (CLL). Possibly the prognosis of chronic lymphatic leukemia can be significantly influenced by early treatment. In acute leukemia the increase of bone marrow proliferation can be useful in cases resistent to chemotherapy. Side effects of ECIB have not been observed.
[Clinical findings in porphyria cutanea tarda].
Disturbances in the iron metabolism can quite frequently be observed in patients with porphyria cutanea tarda. Studies on 10 patients with porphyria cutanea tarda indicate that elevated iron levels are correlated with decreased latent and normal total iron binding capacity in the serum. Morphological examinations of the liver showed alterations as can be found in fatty liver up to cirrhosis, which -- in most instances -- were associated with iron deposits in the hepatocytes.
[Hemolytic components of anemia in patients with long-term hemodialysis].
Hemolysis was investigated in 12 patients on chronic dialysis. A hemolytic component was evaluated by estimation of free hemoglobin concentration, elevated activity of red cell enzymes as well as by reduction of red cell life span to 2/3 of normal. Only in one case where the patient suffered also from familial hemolytic jaundice, splenectomy was necessary.
[Anemia in terminal kidney failure. Pathogenesis and therapy].
Various factors are involved in the pathogenesis of anemia in dialysis patients. Reduced erythropoiesis is mainly attributed to erythropoietin deficiency. Stimulation of erythropoiesis may be promoted by androgens. Substitution of iron is recommended in case of iron deficiency. As a rule, supplementation of vitamin B12 is not necessary, but administration of folic acid is recommended. Treatment of anemia in renal failure is rendered more effective by increased technical efficiency in hemodialysis permitting a relatively protein-rich diet. Blood transfusions are not necessary during routine treatment of dialysis. Since bilateral nephrectomy will always provoke severe anemia, it should be reserved to special cases of severe hypertension. Until now, no conservative therapy has been developed which would allow optimal treatment of anemia in dialysis patients. Successful renal transplantation still is, and will be, the best therapeutic intervention.
[Pyridoxine-sensitive, sideroachrestic anemia with post splenectomy manifestation].
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[Extracorporeal irradiation of blood using 137Cs in the treatment of chronic lymphadenosis. Experience with 14 patients].
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[Haptoglobin in the course of surgery with the heart lung machine (author's transl)].
In 20 patients, who underwent open heart surgery, the results of quantitavely and semi-quantitavely determined haptoglobin (hp) were evaluated. A rapid method (Rapi tex-Hp-Test, Behring-Werke) was used. Five minutes after the heart lung machine was cut off hp decreased slightly, and increased about 200% at the 4th day after operation, compared to the preoperative value. These changes were less pronounced in patients with prosthetic heart values. Blood transfusions did not influence the results. There is a significant correlation between the results of hp determined quantitatively and semi-quantitatively.
[Anemia in patients with artificial heart valves (author's transl)].
The pathogenesis of anemia in 84 patients with valvular protheses of the heart was investigated. A secondary deficiency of serum iron and folate, caused by chronic hemolysis, was found. There was no indication of vitamin-B12-deficiency.
[Correlations between lymphocyte subpopulation and stage of disease in chronic lymphatic leukemia of Rai].
T- and B-lymphocytes have been studied in 36 patients with chronic lymphatic leukaemia (CLL). Each 12 cases remained untreated or were treated with chlorambucil or extracorporeal irradiation of the blood (ECIB). The patients were classified according to the staging system proposed by Rai et al. In all groups we found significantly elevated B- and T-cells. There was no correlation between the stage of the disease and the proportion of lymphocytes. B-lymphocytes were reduced significantly by ECIB, whereas T-lymphocytes have not been influenced.
[Serum folic acid, vitamin b12 and iron values during pregnancy (author's transl)].
Of 125 pregnant women, of whom 81 were treated and 44 not treated, 14 (12,5%) were found to be suffering from anemia, with a hemoglobin count to be diminished. In 31 cases iron deficiency was established and in 8 women vitamin B12 in serum was reduced. Iron and vitamin deficiencies were found more frequently in the non-treated group than in the treated group.
[Clinical significance of the folic acid content in plasma and erythrocytes].
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[Hemolysis after extracorporeal blood irradiation of man?].
Haemolysis was studied before and after extracorporeal irradiation of the blood of 20 chronic lymphadenosis patients. Free haemoglobin, haptoglobin and haemopexin were not affected by irradiation, indicating that no haemolysis was caused by the transit dose accumulated during the applied procedure.
[The effect of extracorporeal blood radiotherapy on the peripheral blood T and B-lymphocytes in chronic lymphadenitis].
B-lymphocytes and T-lymphocytes were determined before and after therapy in 12 patients with chronic lymphatic leukemia (CLL) treated with extracorporal blood radiation (ECIB). There was a significant decrease of B-lymphocytes (p less than 0.001) from 85.3 +/- 6.55% to 71.55 +/- 10.60% by ECIB, whereas no significant changes could be found in T-lymphocytes. 12 untreated CLL patients, whose B-lymphocytes amounted 83.25 +/- 6.79% with 7.5 +/- 3.42% of T-lymphocytes, were examined as group of comparison. From these findings ECIB is concluded to cause a decrease of accumulated B-cells.
[The diagnosis of vitamin B 12 deficiency].
In 5 normal persons, 1 patient with pernicious anemia, 5 patients with renal insufficiency in the state of compensation, and in one patient with chronic hemodialysis Schilling tests, activity of 57Co and vitamin B12 serum levels were measured. It was obvicous that activity of 57Co in serum 8 hours after oral application of 0.5 muCi 57Co-vitamin B12 showed reliable results to clear the problem of vitamin B12 malresorption. This method is easier than the Schilling test because the collection of 24-hour-urine is not necessary and an insufficiency of renal function does not influence the result.
[The vitamin B 12 serum level at various ages].
A report is presented on the determination of the vitamin B12 content by means of radioassay in the serum of 402 healthy persons aged between 14 to 98 years. With increasing age a significant decrease of the vitamin B12 content could be observed in both sexes after the sixtieth year of age. In the age group between 21 to 30 only the low values of women made an exception, which may be due to the administration of contraceptives.
[Haptoglobin in various diseases].
The clinical significance of haptoglobin (Hp) can be seen in the fact that its serum concentration shows a specific pattern in certain diseases and under various therapeutic measures. The determination of Hp is not only indicated in haemolytic anaemias, but also in liver and kidney diseases, infections, diseases of the connective tissue, malignant tumours, and under certain therapeutic conditions.
[Anemia in female adolescents].
Investigations for exploring the frequency and pathogenesis of anaemia were carried out in 164 female pupils of a minicipal grammar school for girls aged from 14 to 20 years. There were lowered haematocrit values below 37% in 81 cases (49%), which were due to iron deficiency in 31 girls. Only in one case a lowered vitamin B12 level was detected and in 8 girls there was a lowered folic acid content in the serum. The frequency of anaemia in girls of school age mainly caused by iron deficiency is emphasized.