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Biomedical subjects

E Heilmann

Publications and source records attributed to E Heilmann.

At least 109 records · Page 6Linked to original sources
PubMed1976

[Folic acid substitution in hemodialyzed patients. Folic acid levels in plasma and erythrocytes].

Investigations of folic acid levels in plasma and erythrocytes. In 20 patients on hemodialysis with and without folic acid substitution the concentration of folic acid in plasma and in red cells was estimated by radioassay. In patients, who were substituted with folic acid concomitantly with elevated folic acid concentrations hematocrit values were higher than those of patients who were not substituted. Folic acid concentrations in patients not substituted. Folic acid concentrations in patients not substituted were subnormal and further decreased on dialysis. Results of folic acid determinations in plasma were paralleled by concentrations in erythrocytes. It is concluded, that folic acid substitution is necessary in patients on hemodialysis.

Adolescent↗
PubMed1976

[Folic acid determination in the serum and erythrocytes by means of a competitive binding method with 125 iodine labeling].

Folic acid concentration in serum and erythrocytes was measured by radio assay according to the principle of competitive binding to proteins with 125I as marker. The method yielded a linear regression with readily reproducible results. The mean value in controls was 7.05 -+/ 3.4 ng/ml in serum and 386.8 -+/ 215.1 ng/ml in erythrocytes. In chronic alcoholics the respective values were significantly lower: 4.79 -+/ 2.02 ng/ml for serum and 344.4 -+/ 198.9 ng/ml for erythrocytes. The clinical importance of folic acid estimations arises from the general frequency of folic aicd deficits. Latent folic acid deficiency is associated with lowered folic acid concentrations in serum and normal values in red cells. In manifest folic acid deficiency both concentrations are decreased.

Alcoholism↗
PubMed1976

[Familial hemolytic anemia and terminal renal failure (author's transl)].

We report about a patient with corpuscular hemolytic anemia and chronic glomerulonephritis in the state of terminal renal failure. The hematocrit decreased to 11% gradually with the progression of uremia. The hematological studies revealed the typical signs of hemolytic anemia. We found a splenic destruction of 51-Cr labelled red cells combined with an extremely short red cell life of 7 days. After splenectomy hematocrit improved to 32%. A complete normalisation could not be expected because of the chronic renal failure leading to anemia itself.

Adult↗
PubMed1976

[Iron deficiency following implantation of a heart valve prosthesis].

In 44 patients with single or multiple valvular protheses of the heart, the problem of secondary iron deficiency due to mechanical hemolysis was investigated. In 17 cases, elevated serum transferrin values were noted, compared to elevated serum iron levels in only 6 cases. Therefore, treatment should be based on the more reliable transferrin values. Severity and duration of mechanical hemolysis did not seem to be correlated with the occurrence or the degree of iron deficiency.

Adult↗
PubMed1975

[Proceedings: Plasma hemoglobin in patients with intermittent hemodialysis with special reference to various dialysis procedures].

In the pathogenesis of anemia in patients on intermittent hemodialysis is a frequently mentioned factor. To evaluate the red blood cell trauma caused by the hemodialyser, free hemoglobin was determined in the plasma before and after various types of hemodialysis. We investigated 22 patients with chronic renal failure in the age range from 18 to 54 years who were hemodialysed with various types of shunt (Cimino, Scribner or Thomas shunt) and hemodialysers (Kiil or Rhone-Poulenc). Determinations of hemoglobin in the plasma before and after 8-h hemodialysis were performed by the method of RICHTERICH. A significant increase in the initial normal values for hemoglobin in the plasma were found, but without any correlation between rate of hemolysis and type of hemodialyser. The presumed mechanical destruction of erythrocytes during hemodialysis can be determined by the free hemoglobin in the plasma. The small extent of intravascular hemolysis does not correlate with the type of hemodialyser.

Adolescent↗
PubMed1975

[Proceedings: Studies on mechanically induced hemolysis following prosthetic heart valve replacement].

Investigations into the problem of mechanical hemolysis were carried out in 28 patients with one or more prosthetic heart valve replacements. Signs of compensated intravascular hemolysis were demonstrated in all cases by determination of lactic dehydrogenase activity and free hemoglobin in the serum. We found no correlation between the type and number of prosthetic heart valves and the incidence of hemolysis.

Adult↗
PubMed1975

[Anemia in chronic renal insufficiency].

Anemia is known as one of the earliest manifestations of chronic renal insufficiency. Anemia begins at a serum creatinine level of 2 mg/100 ml. There is no correlation between the degree of anemia and the etiology of renal disease. Patients on chronic hemodialysis shown an average hematocrit of 23%. In the pathogenesis of renal anemia various factors may be discussed, especially a deficiency of iron and erythropoietin. A method of conservative therapy which would allow optimal treatment of renal anemia is not yet available. Successful renal transplantation has to be considered the best therapeutic measure in terminal renal insufficiency.

Anemia↗