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Biomedical subjects

E Heilmann

Publications and source records attributed to E Heilmann.

At least 73 records · Page 4Linked to original sources
PubMed1979

[Investigations of iron and folate levels in serum after implantation of heart valve prostheses (author's transl)].

In 90 patients with prosthetic heart valves, the presence of iron and folate deficiencies was assessed in a double-blind study. Anemia was found in 18 cases. Average serum iron levels were below the normal range and could be incremented significantly through the administration of 193 mg Fe++ daily during a 4-week period. No evidence of folate deficiency was found.

Anemia, Hypochromic↗
PubMed1979

[Relationship between the capacity to be stimulated of lymphocyte subpopulations and the RAI staging in patients with chronic lymphocytic leukemia].

By means of the incorporation rate of 3H thymidine into the lymphocytes of patients with chronic lymphatic leukaemia the possibility of stimulating them by using different mitogens was checked and compared with normal persons. The examination covered 11 patients treated with extracorporeal irradiation of the blood (ECIB), 5 patients treated with a chlorambucil therapy, and 10 untreated patients who were classified according to the staging system proposed by RAI. The lymphocytes of the peripheral blood were stimulated as mixed and isolated T and B-lymphocytes in the microculture by using the mitogens PHA, PWM, ConA, and LPS. In all CLL patients there was a diminished stimulation rate of a mixed lymphocyte population. A relation existed between the seriousness of the stage and the diminution of the incorporation rate of 3H thymidine. A corresponding correlation could not be identified in untreated CLL patients. Isolated T-lymphocytes revealed better results of stimulation than the total population. As to their function B-lymphocytes showed a dependance on the kind of therapy. In the mixed lymphocyte culture of normal persons the best findings could be observed after stimulation with PHA, that is also valid for CLL patients. PHA, PWA, ConA, and LPS were suitable as substances stimulating B-lymphocytes with different efficacy in normal persons and CLL patients. Both collectives showed the best results in the T-lymphocyte culture after stimulation with LPS.

B-Lymphocytes↗
PubMed1979

[Case contribution to the study of hemoglobin C disease].

Haemoglobin-C disease represents a haemoglobinopathy seldom occurring in our latitudes. In its homocygotic form it coincides with haemolytic anaemia and splenomegaly. The diagnosis of haemoglobin-C disease could be ensured in a 33 years old Yugoslav patient who had been treated because of being suspected of a venous thrombosis of the spleen. The knowledge of this disease taking prognostically a benign course seems to be important in order to prevent patients from unnescessary diagnostic and therapeutic measures.

Adult↗
PubMed1978

[Folic acid and vitamin B 12 in chronic alcoholics].

In 64 chronic alcoholics folic acid and vitamin B12 in plasma and folic acid in erythrocytes were determined. The mean values of folic acid in plasma and in erythrocytes were significantly below normal. The determination of vitamin B12 showed normal results in a group of 20 cases treated with vitamin B12 containing drugs, whereas in the group of untreated alcoholics significantly reduced values were found. Comparison of folic acid and vitamin B12 concentrations in plasma revealed a more frequent deficiency of folic acid than of vitamin B12, which was combined with anemia in half the alcoholics investigated. The need to treat chronic alcoholics with folic acid and vitamin B12 is pointed out.

Adult↗
PubMed1978

[Polycythemia vera, clinical aspects and disease course].

The data of 140 patients with polycythemia vera during the period 1955--1975 were analyzed with regard to clinical signs and prognosis. The average age was 53,4 years. The sex ratio was 1.9:1 in favor of men. The most frequent symptoms were headache and vertigo. In more than half of the cases hepatosplenomegaly and hypertension were found. Besides typical changes in the blood count with elevated erythrocytes, hemoglobin, hematocrit, leukocytes and thrombocytes, increased levels of alkaline leukocyte phosphatase and uric acid were found. As to therapy, after 32P-medication the survival was two years longer than after phlebotomy. In 9 patients osteomyelofibrosis developed, and in 7 cases chronic myeloic leukemia. The mean age of death was 61 years.

Adolescent↗
PubMed1978

[Compensatory mechanisms of haemolysis after surgery with the heart-lung-maschine (author's transl)].

In 20 patients, suffering from various diseases, the extent of haemolysis and the correlation between the rate of haemolysis and various mechanisms of erythrocyte damage in the course of open heart surgery was studied. We investigated haemotological parameters, electrolytes, lactate dehydrogenase before, and 1, 3, 5, and 7 days after operation. Besides free haemoglobin, haptoglobin and haemopexin were determined 5 and 15 minutes after starting perfusior with the heart-lung machine and after finishing. The best index of haemolysis was free haemoglobin in the serum. With increasing duration of perfusion the rate of haemolysis increased. Compensating mechanisms were postoperative increase of haptoglobin and haemopexin.

Cardiac Surgical Procedures↗
PubMed1978

[Fragmented erythrocytes (schizocytes) after surgical interventions].

Fragmented erythrocytes (schistocytes) develop as a consequence of erythrocytes being damaged mechanically. Cardiac and vessel anomalies as well as diseases of small vessels with disturbances of the microcirculation may be considered as the main causes. Intravasal haemolysis appearing after artificial heart valve replacement is characterized by the appearance of schistocytes. In laboratory chemical respect there are signs of a haemolysis. The treatment depends on the seriousness of clinical symptoms.

Bed Rest↗
PubMed1978

[Clinical treatment of chronic lymphatic leukemia by means of extracorporeal blood irradiation].

A chronic lymphatic leukaemia (CLL) with hepato-splenomegaly was treated in a 76 years old female patient by means of extracorporeal irradiation of blood (ECIB), after which a complete involution of the tumour in the spleen had taken place. Leukocytes initially increased to 35,500/mm3, amounting to 10,700/mm3 later on. The patient died of pneumonia in general cachexia. No signs of CLL could be found macroscopically after autopsy. An involution of the lymphatic infiltration could be identified microscopically in the bone-marrow.

Aged↗
PubMed1978

[A plasmacytoma with changing paraproteinemia].

A disease on myeloma is described which originally showed an IgA paraproteinaemia. 3 years later a paraprotein of IgM-typ could be identified by the immunoelectrophoresis. Clinical progress and examination of the bone marrow revealed the unequivocal diagnosis of multiple myeloma. In spite of IgM paraproteinaemia the formation of Waldenströms' disease did not occur.

Humans↗
PubMed1978

[Animal experimental studies of hemolysis following extracorporeal blood irradiation].

In experimental studies on animals, extracorporal blood irradiation was performed in 3 sheeps and 1 goat by means of 500 Ci 137 cesium source. The sheep died of the sequelae of narcosis, with anaemia being only moderately marked. In the goat a transit dosis of 466566 rad could be applied before the animal died of the sequelae of haemolytic anaemia.

Animals↗