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Biomedical subjects

E Haneke

Publications and source records attributed to E Haneke.

At least 127 records · Page 7Linked to original sources

[Clinical significance of positive penicillin test reactions (author's transl)].

Epicutaneous, scratch and intracutaneous tests with various penicillins and their major as well as minor determinants were performed on 495 patients either because they were suspected of having a penicillin allergy, or in order to exclude such allergy, or before starting penicillin treatment, or because they suffered from chronic recurrent urticaria. A positive test reaction occurred in 25%: 44% among those with a history pointing to penicillin allergy and 17.8% among those who were tested before treatment to exclude penicillin allergy. Positive reactions also occurred in 11% of patients with chronic recurrent urticaria, but in practically all instances were clinically without significance. D-Penicillamine (Metalcaptase) and penicilloyl-polysine in the intracutaneous test, penicillin-G-sodium and ampicillin in the epicutaneous test gave the highest incidence of positive reactions.

Ampicillin↗

[Sea urchin granulomas].

Sea-urchin granulomas are chronic granulomatous skin lesions arising as a delayed reaction a few months after the initial injury by sea-urchin spines. Spontaneous resolution may occur.

Adult↗

[Cross allergies following sensitization with dinitrochlorbenzol (DNCB)].

82 of 203 patients with malignant melanoma and other skin diseases suitable for DNCB-immunotherapy were re-exposed to standard test substances, chloramphenicol, and another four p-nitrocompounds similar to DNCB by epicutaneous patch tests 6-15 months after primary sensitization with DNCB. The DNCB sensitizaton threshold proved to be unchange. No cross allergy with chloramphenicol was observed However, two patients showed sensitization against picric acid not seen before. A group allergy may be suggested in both cases. Immunotherapy with DNCB is briefly discussed. Apart from a very low rate of group sensitization, topical treatment with threshold concentrations of DNCB has neither toxic effect nor produces scarring nor generalized eczema.

Cross Reactions↗

[Seasonal burning palate in allergy against grass pollen].

An immediate type I allergy elicited by IgE antibodies against pollen of grasses and cereals was demonstrated as the rare cause of palatinal stomatopyrosis (burning palate). The casual relationship was suggested through history and proven by skin, radioallergosorbent and exposition tests.

Adult↗

The Papillon-Lefèvre syndrome: keratosis palmoplantaris with periodontopathy. Report of a case and review of the cases in the literature.

The Papillon-Lefévre syndrome (PLS) is an autosomal recessive trait characterized by diffuse transgredient palmar-plantar keratosis (PPK) and premature loss of both the deciduous and permanent teeth. In most cases, the PPK is noted within the first 3 years of life. The periodontal lesions begin shortly after the start of both the primary and the permanent dentitions. The teeth are affected in the order of their eruption, exhibiting inflammation of the periodontal tissue, bleeding of the gums, pocket formation, loosening, and finally spontaneous exfoliation without showing definite signs of root resorption. After an edentulous interval, the same process begins anew shortly after the second dentition. Ectopic intracranial calcifications, mental retardation, and increased susceptibility to infections have often been seen in PLS patients and may thus be regarded as facultative signs.

Child↗

[Levamisole therapy under different dermatological indications].

More than 180 patients were treated for immunostimulation with levamisole within three and a half years. The results were statistically evaluated in 128 subjects. A highly significant improvement was noted in 44 patients suffering from recurrent herpes simplex labialis, facialis and oralis. 14 patients with recurrent herpes genitalis, lumbalis and glutaealis only experienced a reduction of the recurrence frequency. Aphthae in 16 subjects became less frequent and pain was reduced. Levamisole should be tried in recalcitrant chronic candidoses and bacterial infections not responding to specific antibiotic treatment. Slight side effects are relatively frequent, but severe ones are only rarely observed.

Adult↗

The dermal component in melanosis naeviformis Becker.

Histological investigations were performed in 11 subjects suffering from melanosis naeviformis Becker. Apart from the well-known epidermal alterations such as basal hyperpigmentation, slight acanthosis and growth of coarse hair, dermal changes were found in each case. The dermis was considerably thickened and contained numerous small and/or large bundles of smooth muscle without relation to cutaneous adnexa. Thus, melanosis naeviformis Becker can be considered an organoid nevus with epidermal, melanocytic and dermal components.

Humans↗

[Psychological aspects of glossodynia (author's transl)].

The term glossodynia refers to all conditions with pain and dysaesthesia of the tongue and entire oral mucosa manifesting themselves in burning, prickling, itching, stinging, and other frequently bizarre sensations as well as subjective xerostomia and bad taste. In most cases psychiatric diseases are the cause of the complex of complaints whereas local and general disorders are of only minor importance. Menopausal women with atypical depression are most often affected. Schizophrenia and abnormal personality development are far less frequent in glossodynia. After exclusion or therapy of organic disorders antidepressants are the treatment of choice in glossodynia. Thereapeutic difficulties may arise in patients suffering from marked xerostomia whose complaints may intensify during therapy because of the anticholinergic effect of most antidepressants, and in neurotic persons.

Adult↗

[Morphological variants of folliculitis barbae candidomycetica].

Report on two cases of folliculitis barbae candidomycetica (f.b.c) which mimicked impetigo contagiosa in one case and tinea barbae in the other. Both patients suffered from typical predisposing factors such as leukemia, cytostatic and corticosteroid therapy, and diabetes mellitue. Taking into consideration the morphology of cases described earlier in this journal, three types of f.b.c. can be recognized: folliculitis simplex-like type, tinea barbae-like type and impetigo-like type.

Candidiasis, Cutaneous↗

[Generalized syringomata].

Two cases of generalized syringomata showing an uncommon dissemination and density of tumors particularly on thighs, back and abdomen, are demonstrated. Clinically there is similarity with urticaria pigmentosa adultorum. Histological investigation is essential for clinical diagnosis.

Abdomen↗

[Subungual melanoma with linear nail pigmentation].

A 53 year old male patient presented with a dark-brown linear pigmentation of the thumb nail due to a subungual melanoma mainly of the superficial spreading melanoma-type. Melanin-induced nail pigmentations are recommended to be treated by a resection in local anaemia of the dorsal two thirds of the terminal phalanx. This procedure combines sufficient radical surgery with a good functional and acceptable cosmetic result.

Fingers↗

[Late-onset cutis laxa (generalized elastolysis)].

Cutis laxa is a heterogeneous disease of elastic fibres, divided into three congenital and two acquired forms. Its aetiology is unknown except for the X-linked recessive form. A late form with slow progression in a 52-year-old woman and a probably postinflammatory form in a 29-year-old woman are reported. In both cases histological examination revealed severe damage of the elastic fibres of the skin, in the first one also calcium deposits and (electronmicroscopically) damage to collagen fibres. Treatment is entirely symptomatic, but in severe cases plastic surgery may help cosmetically.

Adult↗