[pK and Vk measurements on benzodiazepines].
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Biomedical subjects
Publications and source records attributed to E Graf.
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Conventional gnathological concepts concerning border movements, intermaxillary relations and terminal hinge movement of the mandible have been complemented by definitions obtained from observations in children, particularly orthodontic patients. While gnathologists tend to prefer the hand guided technique for diagnostic centric relation to the unguided method, the orthodontists on the other hand do not attribute the necessary importance to the guidance of the mandible into centric relation. By prevention or elimination of occlusal interferences, RCP/IP discrepancies, of balancing and particularly hyperbalance contacts, by possibly creating a type of occlusion as conceived by gnathology, the orthodontist may--within certain limits--be able to prevent TMJ disturbances and/or peridontal disease. Hopefully it may be at the same time possible to obtain more stable results of successful orthodontic treatment. The described functional analysis is designed to invite a more dynamic concept of the masticatory system.
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The pharmacokinetics of orally applied "essential" phospholipids (EPL) (i.e. polyenyl phosphatidyl choline) was investigated in conscious and in anesthetized rats with the aid of radioactively labelled dilinolyl phosphatidylcholines (3H and 14C.). Absorption, distribution and metabolism of EPL were studied using autoradiography and by measuring the distribution of the abosrbed radioactivity in lymph, blood and internal organs, and by determining excretion and expiration.
A method is described for the measurement of cerebral blood flow by coutinuous registration of the venous out-flow from the temporal sinus of anaesthetized dogs. This method can be used advantageously for the screening of unknown compounds because samples of "cerebral" venous blood are obtained by a less complicated and reliable technique. Changes in cerebral blood flow induced with well defined substances, were registered with our method. The results are discussed.
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