[A new method for the determination of total alkaloids and of cephaeline in Ipecacuanha].
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Biomedical subjects
Publications and source records attributed to E Graf.
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Prognostic classification schemes have often been used in medical applications, but rarely subjected to a rigorous examination of their adequacy. For survival data, the statistical methodology to assess such schemes consists mainly of a range of ad hoc approaches, and there is an alarming lack of commonly accepted standards in this field. We review these methods and develop measures of inaccuracy which may be calculated in a validation study in order to assess the usefulness of estimated patient-specific survival probabilities associated with a prognostic classification scheme. These measures are meaningful even when the estimated probabilities are misspecified, and asymptotically they are not affected by random censorship. In addition, they can be used to derive R(2)-type measures of explained residual variation. A breast cancer study will serve for illustration throughout the paper.
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The prevalence of diabetes mellitus and the distribution of serum glucose levels among 254 immigrant Ethiopian Jews (Operation Solomon) were studied immediately after their arrival in Israel in 1991. No case of diabetes was found. Although the body mass index of this population was higher than those obtained in Operation Moses, the serum glucose levels in almost all age-groups were significantly lower.