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Biomedical subjects

E Graf

Publications and source records attributed to E Graf.

At least 73 records · Page 4Linked to original sources
PubMed1981

Failure of naloxone to antagonize metoclopramide induced prolactin rise.

Seven subjects aged 21--54 years were investigated. Serum PRL and DBH were estimated before and at 30, 60, 90 and 120 min after the administration of 20 mg clopropamide. The same parameters were estimated a second time when 0.4 mg naloxone was associated. PRL level increased and DBH decreased in all the patients in both investigations and no significant differences between the two occasions were detected. It is suggested that probably the two substances do not act on identical receptors.

Adult↗
PubMed1980

Method for determination of hydrogen peroxide, with its application illustrated by glucose assay.

We describe a simple colorimetric method for determining micromolar quantities of hydrogen peroxide, based on the oxidation of iodide in the presence of ammonium molybdate and photometry of the resulting blue starch-iodine complex. Color development is linearly dependent on analyte concentration, but only slightly time dependent, and the color of the complex formed is stable for several hours. In the range of wavelengths that may be used (570 to 630 nm), lack of interference from other biological compounds makes this method seem suitable for routine analyses. As one illustrative application of the method we quantitated glucose by measuring hydrogen peroxide produced from it by glucose oxidase catalysis. This method of quantitating glucose is more than five times as sensitive as the commonly used dianisidine method. With the appropriate hydrogen peroxide-producing oxidases, this method may be used to directly measure amino acids, purines, uric acid, xanthine, and hypoxanthine.

Colorimetry↗
PubMed1979

[Displacement of the hinge angle point in a Class II malocclusion; 1 case report during treatment with a Bern activator (an interim report)].

In the context of a global examination of the effects of the activator therapy of Herren in class-II malocclusion, the position of the hinge axis points was studied in a group of 12 consecutive cases (9 boys and 3 girls). The hinger axis was recorded immediately before and in the course of the treatment, using a standardised recording method. After 1 mm change in occlusal relationship, the hinge axis points were located about 2 mm caudally of the tattooed zero point. When the change in occlusal relationship step by step had reached 3, 5 and 7 mm, and even after 6 months of retention, the hinge axis points had moved back by about 1 mm in a cranial direction, but remained still about 1 mm caudally of point zero. In a sagittal direction, a facial dislocation of about 1 mm was found no sooner than after a 6-months retention time. A study on reproducibility was used to ensure the statistical proof of these results.

Activator Appliances↗
PubMed1978

Central nervous effects of a new tricyclic antidepressant (amitriptylinoxide).

The central action of amitriptylinoxide was investigated in mice and rats using established models. The substance was found to possess antidepressant, drive-promoting properties which correspond to amitriptyline in their intensity or are superior even. In addition the pharmacodynamic spectrum of amitriptylinoxide displays a sedative component that is considered a desirable accompanying effect but is somewhat weaker than with amitriptyline. According to revealed differences in this work between the pharmacological activities of amitripytlinoxide and those of other tricyclic antidepressants, it became reasonable to undertake further studies to investigate its main and side effects.

Aggression↗
PubMed1978

[Isolation and pharmacodynamic activity of the sesquiterpene valeranone from Nardostachys jatamansi DC].

The known sesquiterpene valeranone (= Yatamanson) was isolated from the subterranian parts of Nardostachys yatamansi (DC). It was pharmacologically investigated in animal experiments of sedative, tranquilizing and antihypertensive properties. In some experiments, typical for tranquilizers, certain activities could be demonstrated such as the prolongation of barbiturate hypnosis, the impairment of rotarod performance, an anticonvulsive activity on electric shock and potentiation of the body-temperature lowering activity of reserpine. In three other pharmacological models an anti-ulcer action was detected. In general the activity of valeranone was lower than those of the standard substances used. As regards the hypotensive property only a weak activity was demonstrated. In toxicological studies on rats and mice an oral LD50 of greater than 3160 mg/kg was found, which suggests the possibility of a therapeutically useful dose ratio.

Aggression↗