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Biomedical subjects

E Cardan

Publications and source records attributed to E Cardan.

At least 37 records · Page 2Linked to original sources
PubMed1977

Pseudocholinesterase changes in anesthesia using pancuronium.

Pseudocholinesterase activity was investigated in three groups of unselected patients. A slight rise of the enzyme was found during surgery under local anesthesia with lidocaine. In general anesthesia with thiopentone and halothane, the pseudocholinesterase activity diminished. The inhibition was more pronounced when pancuronium had been injected. From these data one may conclude that pancuronium must be carefully given in patients with low level of pseudocholinesterase when other drugs inhibiting the enzyme activity, like succinylcholine, procaine and propanidid, are used.

Anesthesia, Inhalation↗
PubMedDate not supplied

[Muscular clearance after administration of phenoxybenzamine in shock].

The authors made an experimental investigation in the dog concerning the evolution of the muscular clearance of phenoxybenzamine in the course of de-shocking procedures. The animals were shocked by hemorrhage and were treated by perfusion of volemic mass and administration of phenoxybenzamine. This substance was flowed in paralell with the hemodynamic parameters and the rhythm of the diuresis. It was noted that the direction and the amplitude of changes concerning the half-life of Na131I do not depend on the blood pressure.

Animals↗
PubMedDate not supplied

[Involvement of the thyroid gland in clinical shock (anti-shock action of propylthiouracil)].

Propylthyouracil, a synthetic anti-thyroid drug, was given intravenously in ten patients in a severe shock condition and its action was followed on the blood cathecholamines. This was assessed in venous blood according to a modified colorimetric method by Manuhin, before and 30 minutes after the substance was perfused. Although statistically non-significantly the two amines show a tendency to fall after the administration of the drug. In line with a series of previous studies carried out in various institutes of chemical and pharmaceutical research the drug was given for the first time in humans in shock conditions. Discussing the results obtained the administration of propylthyouracil is recommended, as an adjuvant therapy in severe shock.

Adrenal Glands↗
PubMedDate not supplied

[Serum acetylcholinesterase changes after pancuronium administration].

The acetylcholinesterase activity was followed, as a variant of true cholinesterase, in three groups on non-selected patients: 10 of these were under local anesthesia with lidocaine, 12 were under general anesthesia with thiopenthal and halotane and 43 were under the same type of general anesthesia, that had also been given Pancuronium as a muscle relaxant. A slight inhibition was noted of the enzyme activities in the course of local anesthesia and a more significant one in the course of general anesthesia. The enzyme concentrations were lower in those patients that had also received Pancuronium, suggesting a cummulative inhibitory effect on serum acetylcholinesterase. The changes were not significant from the statistical viewpoint.

Acetylcholinesterase↗
PubMedDate not supplied

[Practical aspects of the treatment of Darrow's syndrome].

An analysis is made of a group of 30 patients who, in the course of the evolution of their basic disease,have also presented, at a certain time, lowered potassium concentrations in the blood and metabolic alkalosis. As etiological factors the frequency is stressed, of conditions in the course of which stasis gastric juice is lost, the chronical lack of potassium import, as well as corticoid therapy. Special attention is given to circumstances imposed by oedema of the anastomosis opening. Interpretation and monitoring of the treatment were carried out on the basis of sophisticated, as well as current laboratory methods, but the importance of the clinical signs is stressed, when a well-equiped laboratory department is not available.

Alkalosis↗
PubMedDate not supplied

Heterozygous protein C deficiency and coumarin necrosis of the skin.

An obese female patient aged 47 with a personal and familial history of recurrent venous thrombosis, who developed a coumarin-induced skin necrosis is presented. Laboratory investigations, performed three months after the acute event and in absence of coumarin therapy, emphasized a decreased anticoagulant activity of her plasma protein C (50% of the normal). These results as well as the high incidence of thrombotic disease in her relatives point to a familial heterozygous protein C deficiency. The antithrombotic role of the protein C system and the mechanism of coumarin induced necrosis of the skin are briefly discussed.

Coumarins↗