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Biomedical subjects

E Cardan

Publications and source records attributed to E Cardan.

At least 19 recordsLinked to original sources
PubMed1988

Room air ventilation for total intravenous general anaesthesia.

The use of room air alone to ventilate patients who were anaesthetized with total intravenous anaesthesia, including morphine 2 mg.kg-1, was studied in ten patients. The were scheduled for gastrectomy for peptic ulcer or stomach carcinoma. The patient's minute-ventilation was measured the day previous to surgery; this, together with a frequency of 14 c.min-1, was used to preset the ventilator. Alveolar ventilation, end-expiratory CO2, arterial blood gases and acid-base balance were monitored throughout the procedure. The blood oxygen level was found to remain similar to the reference value; there was a moderate hypocapnia, a low end-expiratory CO2 and minimal changes in acid-base balance. No pulmonary complication was encountered in the postoperative course. These results showed that room air could be used in unusual circumstances for healthy patients for whom a total intravenous anaesthetic technique has been chosen.

Adult↗
PubMed1986

Inhibitory effect of disodium edetate on gastric secretion.

Disodium edetate (ethylenediaminetetraacetic acid, disodium salt; disodic EDTA), 3 g, was given, via an intravenous normal saline drip of 30 min, to 25 patients in order to assess a benefit for anaesthesia practice. A significant reduction of both volume and acidity of the gastric secretion was found in all the 10 patients with peptic ulcer having received the drug. The peak of the change was 1 h after administration. In other 10 non-ulcer patients undergoing orthopaedic surgeries under epidural anaesthesia with lidocaine 2%, 5 mg kg-1, pH of the gastric juice unanimously rose, from 2.24 +/- 0.28 to 4.10 +/- 0.21 1 h after EDTA with a P derived from paired difference analysis of less than 0.001. A similar group of patients receiving only normal saline showed no important changes in pH (from 2.37 +/- 0.24 to 2.34 +/- 0.19). The pH of the fundic surface, measured directly under fiberscopic control in further 5 patients suffering from peptic ulcer, was found also to rise from 1.84 +/- 0.21 to 4.62 +/- 0.34 1 h after EDTA, P less than 0.001. Total and ionized calcium changed unsignificantly. Disodic EDTA in the dose and manner used in this study showed no clinical side-effects. The constant and obvious effect of inhibition of the gastric secretion as well as the dynamics of such an action recommend disodic EDTA to be tried in reducing the aspiration pneumonia morbidity.

Adult↗
PubMed1984

Naloxone and pentazocine given after morphine.

Morphine 0.3 mg kg-1 was i.m. given to 25 patients after upper abdominal operations, for analgesia purpose. One hour later, naloxone 0.01 mg was injected i.v. for every 1 mg morphine given. Ten minutes later, pentazocine 0.5 mg kg-1 was also injected i.v. in order to appreciate how it could counteract the reduction in analgesia level caused by naloxone. Complete analgesia could be found in all patients after the mentioned dose of morphine. The minute-ventilation and respiratory frequency were reduced from 7.74 +/- 0.66 to 6.88 +/- 0.77 l (decrease not significant J and from 22.76 +/- 0.98 to 17.44 +/- 0.88 (p less than 0.001). Naloxone partially restored their values, to 7.70 +/- 0.55 l and 18.96 +/- 0.88, but 17 patients out of 25 immediately complained of wound pain. Pentazocine improved analgesia again, in all patients, but also depressed the minute-ventilation to 6.43 +/- 0.48 l, without evident changes in respiratory frequency. If the respiratory changes after morphine and naloxone-pentazocine are compared, it is to emphasize that the distribution of the values was much less after the drug combination, 0.56 in comparison with 1.44, P (Fischer Snédécor test) less than 0.001, showing a more homogeneous improving of the minute-ventilation. In conclusion, if pentazocine is added to naloxone, while a respiratory depression caused by morphine has to be reversed, the analgesia level is maintained and the respiration is insignificantly reduced.

Adult↗
PubMed1983

Hyperthermia.

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Adult↗
PubMed1979

Pancuronium requirements. With special reference to serum protein pattern.

Requirements of pancruonium were evaluated in 50 adult patients undergoing abdominal surgery in halothane anaesthesia. A significant negative correlation was found between gamma-globulin and the apnoeic dose of pancuronium (r = --0.335, P less than 0.02), on the one hand, and the apnoeic period after it (r = --0.311, P less than 0.05), on the other hand. beta-Globulin displayed a significant positive correlation with the apnoeic period after pancuronium (r = 0.344, P less than 0.02). The heavier patients necessitated less drug/kg bw. to obtain apnoea than the leaner ones did. Finally, the females showed a higher sensitivity to pancuronium in comparison to the males.

Adult↗
PubMed1977

Pseudocholinesterase changes in anesthesia using pancuronium.

Pseudocholinesterase activity was investigated in three groups of unselected patients. A slight rise of the enzyme was found during surgery under local anesthesia with lidocaine. In general anesthesia with thiopentone and halothane, the pseudocholinesterase activity diminished. The inhibition was more pronounced when pancuronium had been injected. From these data one may conclude that pancuronium must be carefully given in patients with low level of pseudocholinesterase when other drugs inhibiting the enzyme activity, like succinylcholine, procaine and propanidid, are used.

Anesthesia, Inhalation↗