Biomedical subjects
Publications and source records attributed to E Cardan.
Irian circulation was studied in the course of shock and following injection of phenoxybenzamine. It is concluded that the drug induces an improvement of the irian vasculature, an increase in the number of open vessels and an increase in their diameter.
An analysis is made of a group of 30 patients who, in the course of the evolution of their basic disease,have also presented, at a certain time, lowered potassium concentrations in the blood and metabolic alkalosis. As etiological factors the frequency is stressed, of conditions in the course of which stasis gastric juice is lost, the chronical lack of potassium import, as well as corticoid therapy. Special attention is given to circumstances imposed by oedema of the anastomosis opening. Interpretation and monitoring of the treatment were carried out on the basis of sophisticated, as well as current laboratory methods, but the importance of the clinical signs is stressed, when a well-equiped laboratory department is not available.
An obese female patient aged 47 with a personal and familial history of recurrent venous thrombosis, who developed a coumarin-induced skin necrosis is presented. Laboratory investigations, performed three months after the acute event and in absence of coumarin therapy, emphasized a decreased anticoagulant activity of her plasma protein C (50% of the normal). These results as well as the high incidence of thrombotic disease in her relatives point to a familial heterozygous protein C deficiency. The antithrombotic role of the protein C system and the mechanism of coumarin induced necrosis of the skin are briefly discussed.
Two cases are presented, with accidents of peridural anesthesia, Anesthesia of the entire brain stem, paralysis of the intercostal muscles, and of the upper limbs, apnoea and miosis that developed later indicate an extension of the anesthetic effects far higher that it could have been expected considering the technical details of the procedure. On the other hand the absence of any durable coma, of extreme mydriasis, and of severe arterial hypotension, as well as the relatively rapid retrocession of the additional effects of the administration of an anesthetic exclude the possibility of total rachianesthesia, and it can be concluded that there was an accidental injection of anesthetic in the extra-arachnoid subdural space.
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The renal function was investigated comparatively in two lots of patients with cardiovascular diseases that had been operated with and without extra-corporeal circulation. It was shown that extra-corporeal perfusion alters the renal function in an increased number of cases (28% against 17.75%). Other parenchymatous tissues have also been involved, such as the liver and the pancreas. The humoral parameters and the clinical data are discussed, which demonstrate the organic involvement following such interventions. The good results obtained stress the necessity of an energetic treatment, which should include early dialysis.
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A new technique in preparing a heterograft is presented. Deantigenized calf carotid arteries are obtained by papain digestion and formol tanning. The biochemical determinations show a pronounced reduction in total protein content after papain digestion. The formol tanning gives a good rigidity and elasticity in adapting to different blood volumes without aneurysmal dilatation. Eight dogs were grafted : two died after surgery, two were killed after 35 days and two others 60 days after transplantation, one died after 8 months and one is alive 30 months after transplantation. The good in vivo tolerability has been appreciated. There have been no haemodynamic troubles and no cell changes of rejection. An insignificant quantity of immunoglobulins G has been found in the sera of the animals with heterografts. These data draw attention on the possibility of the use, in clinical practice, of the deantigenized calf arteries.
The case of a patient is described, in whom the clinical aspect of massive liberation of histamine occured during general anesthesia, including bronchospasm, hypotension, generalized congestion of the skin. The changes could be reversed and the surgical intervention was continued. The course of the operation made necessary a prolongation of anesthesia, and re-administration of all the substances which had been included in the procedure. However, the following administration of these substances was not followed by a new liberation of histamine. Short comments are made in connection with the theoretical aspects of this evolution.
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