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Biomedical subjects

E Ascari

Publications and source records attributed to E Ascari.

At least 181 records · Page 10Linked to original sources
PubMed1979

[Acute myeloid leukemia with megakaryocytic predominance and malignant megakaryocyte proliferation. Apropos of 3 cases].

Three cases of acute myeloid leukemia with megakaryocyte predominance are reported. In the first case megakaryocytosis was particularly evident in bone marrow, liver and spleen. In the second case high content of megakaryocytes was observed in the bone marrow and spleen, during the preleukemic phase only. Third case exhibited a strong predominance of megakaryocytes exclusively within the bone marrow. The characteristics of such observations and their nosologic position within myeloproliferative disorders group are discussed, with special reference to modern views concerning myeloid leukemia.

Adult↗
PubMed1978

[Intermittent chronic occlusion of the duodenum caused by pheochromocytoma].

A case (63 y. old male) of intermittent duodenal obstruction is presented. Aortographic investigation showed a neoplastic mass in the right adrenal gland. At laparotomy the mass, histologically diagnosed as a pheochromocytoma, appeared to infiltrate the duodenal wall, displacing it upward. Though gastrointestinal disturbances have been frequently recorded in pheochromocytoma, as far as we know this is the first description of intermittent duodenal obstruction in this disease.

Adrenal Gland Neoplasms↗
PubMed1978

Abnormal splenic uptake of red cells in long-lasting iron deficiency anemia due to self-induced bleeding (factitious anemia).

The authors report on six cases of chronic iron deficiency anemia in which a diagnosis of factitious anemia was made. Erythrokinetic studies demonstrated iron deficiency and blood loss. Besides these features, two kinetic abnormalities are described: precocious splenic sequestration of red cells and excess hemolysis. This hemolytic syndrome seems to be correlated to the duration of anemia rather than to its severity.

Adult↗
PubMed1978

The ultrastructural localization of factor VIII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody.

By means of electron microscopy combined with the use of monospecific anti-factor VIII-antigen (VIIIR:AG) antibodies conjugated to ferritin, the subcellular localization of VIIR:AG in platelets, megakaryocytes and in endothelial cells has been established. The reported results suggest the possibility that the megakaryocyte is able to synthesize VIIIR:AG and also to secrete it by means of a microcanalicular system similar to that present in the endothelial cell. Platelets may derive their VIIIR:AG content partly from the megakaryocyte and partly from the plasma.

Antigens↗
PubMed1978

Behaviour of young and old desialylated rabbit erythrocytes in vivo.

Young and old rabbit erythrocytes, separated by density gradient centrifugation, were desialylated by neuraminidase treatment and reinjected into the animal after 51Cr labelling. Both red cell populations are quickly removed from the circulation and trapped by the liver; then a large percentage of the young cells reappear in the peripheral blood and behaves like untreated erythrocytes; old cells, on the contrary, do not return to the blood stream and are probably lysed in the liver. These results suggest that a sialic acid repair can occur on the membrane of young erythrocytes and confirm that the loss of this molecule is not by itself sufficient to determine the death of the cell.

Animals↗
PubMed1978

[Paraneoplastic syndromes in cancer of the kidney (author's transl)].

Starting with the description of their own observations of paraneoplastic syndromes in adult patients with cancer of the kidneys, the authors discuss the possible pathogenetic mechanisms and the more characteristic clinical features of said syndrome. They conclude by advocating a systematic search for such paraneoplastic syndromes as an aid to early diagnosis of renal malignancy and also as a working parameter for assessing the evolution of the tumor and the effectiveness of treatment.

Amyloidosis↗