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E Arnesen

Publications and source records attributed to E Arnesen.

At least 37 records · Page 2Linked to original sources
PubMed1996

Smoking, serum lipids, blood pressure, and sex differences in myocardial infarction. A 12-year follow-up of the Finnmark Study.

BACKGROUND: Few epidemiological studies have investigated the relative importance of major coronary risk factors in the two sexes within the same study population. In particular, it is not clear whether smoking carries a similar risk of coronary heart disease in men and women. METHODS AND RESULTS: The associations between smoking, serum lipids, blood pressure, and myocardial infarction were examined in a population-based prospective study of 11,843 men and women aged 35 to 52 years at entry. During 12 years, 495 cases of first myocardial infarction among men and 103 cases among women were identified. Myocardial infarction incidence was 4.6 times higher among men. The incidence was increased sixfold in women and threefold in men who smoked at least 20 cigarettes per day compared with never-smokers, and the rate in female heavy smokers exceeded that of never-smoking men. Multivariate analysis identified current smoking as a stronger risk factor in women (relative risk, 3.3; 95% confidence interval [CI], 2.1 to 5.1) than in men (relative risk, 1.9; 95% CI, 1.6 to 2.3). Among those under 45 years old at entry, the smoking-related sex difference was more pronounced (in women: relative risk, 7.1; 95% CI, 2.6 to 19.1) (in men: relative risk, 2.3; 95% CI, 1.6 to 3.2). Serum total cholesterol, HDL cholesterol, and systolic blood pressure were also highly significant predictors in both sexes. CONCLUSIONS: Smoking was a stronger risk factor for myocardial infarction in middle-aged women than in men. Relative risks associated with serum lipids and blood pressure were similar despite large sex differences in myocardial infarction incidence rates.

Adult↗
PubMed1996

Pregnancy related changes in some cardiovascular risk factors.

BACKGROUND: Certain risk factors for development of ischemic heart disease are influenced by pregnancy related changes of female sex hormone levels. METHODS: As a part of the cardiovascular risk factor studies in Finnmark county, Norway, 1974-75 and 1977-78, cross-sectional clinical and non-fasting laboratory data were obtained prior to conception (n = 463), during pregnancy (n = 335), and following delivery (n = 451). RESULTS: Compared with prepregnancy values, total cholesterol was on average 7% lower in the first trimester (p < 0.001), and 30% higher at the end of gestation (p < 0.001). High density lipoprotein cholesterol was 38% higher at mid-pregnancy (p < 0.001), but only 14% higher in the last trimester (p < 0.01). Serum triglycerides were 18% lower in the first (p < 0.001) and 123% higher in the third trimester (p < 0.001). Blood glucose was 5% lower than baseline in mid-pregnancy (p < 0.001). Except for the second trimester, when only 27% of women smoked, more than 40% of the women examined were smokers. Postpartum values were similar to prepregnancy levels, except serum triglycerides which remained 35% higher (p < 0.001) and blood glucose (p < 0.05). CONCLUSIONS: The major serum lipid fractions, and blood glucose, were significantly different during pregnancy and postpartum, which may influence the risk of cardiovascular disease development in women.

Adult↗
PubMed1995

Serum total homocysteine and coronary heart disease.

BACKGROUND: Several studies have observed high plasma levels of homocysteine among patients with coronary heart disease (CHD). The only prospective study was based on US physicians, and concluded that homocysteine was associated with subsequent myocardial infarction (MI). However, the association was limited to those above a threshold level of homocysteine. METHODS: We conducted a nested case-control study among the 21,826 subjects, aged 12-61 years, who were surveyed in the municipality of Tromsø, Norway. Among those free from MI at the screening, 123 later developed CHD. Four controls were selected for each case. RESULTS: Level of homocysteine was higher in cases than in controls (12.7 +/- 4.7 versus 11.3 +/- 3.7 mumol/l (mean +/- SD); P = 0.002). The relative risk for a 4 mumol/l increase in serum homocysteine was 1.41 (95% confidence interval (CI): 1.16-1.71). Adjusting for possible confounders reduced the relative risk to 1.32 (95% CI: 1.05-1.65). There was no threshold level above which serum homocysteine is associated with CHD events. CONCLUSIONS: In the general population serum total homocysteine is an independent risk factor for CHD with no threshold level.

Adolescent↗
PubMed1992

Association between heart rate and atherogenic blood lipid fractions in a population. The Tromsø Study.

BACKGROUND: Prospective epidemiological studies indicate that elevated heart rate may carry increased risk for coronary heart disease. Little is known about the relation between heart rate and serum lipid and lipoprotein concentrations in the general population. METHODS AND RESULTS: We assessed anthropometric and life-style determinants of heart rate and examined the association between heart rate and serum lipid and lipoprotein concentrations in a cross-sectional study of 9,719 men and 9,433 women 12-59 years old. Stratified and multivariate analyses were used to detect possible modification of effect and to control for confounding variables. Heart rate was positively associated with male sex and smoking, decreased with body height and physical activity, and showed a U-shaped relation to body mass index. In both sexes, there was a significant progressive increase in age-adjusted levels of total cholesterol, non-high density lipoprotein (HDL) cholesterol, and triglycerides and a decrease in HDL cholesterol with heart rate. Men with heart rate greater than 89 beats per minute had 14.5% higher non-HDL cholesterol and 36.3% higher triglyceride levels than men with heart rate less than 60 beats per minute. The corresponding differences in women were 12.5% and 22.2%. The associations remained significant when anthropometric and life-style factors were controlled for. The slopes relating total and non-HDL cholesterol level to heart rate were steeper with advancing age. CONCLUSIONS: Increases in heart rate correlate with higher levels of atherogenic serum lipid fractions in the general population. Alterations in aortic impedance and/or autonomic influences may underlie these associations.

Adolescent↗
PubMed1990

Pattern of childbearing and mortality in married women--a national prospective study from Norway.

STUDY OBJECTIVE: The aim of the study was to investigate the effect of different pattern of childbearing on total mortality. DESIGN: A cohort study with all currently married women aged 25 years or more at the Norwegian census in 1970 with follow up to the end of 1985. Information on childbearing was obtained by questionnaires collected by enumerators. Follow up on death was found by a linkage based on the unique Norwegian identification number, between census information and the death register in the Central Bureau of Statistics. SETTING: The study was a national population survey. PARTICIPANTS: A total of 822,593 women with 11.5 million years of follow up and 112,023 deaths. MAIN RESULTS: Nulliparous women had higher mortality than parous women in all age groups. Parity showed a weak association with increasing mortality among high parous women. Lowest mortality was found for parous women with 2-4 children and a late first and last birth, adjusted for socioeconomic group by level of women's education. CONCLUSION: The findings indicate that postponed childbearing may benefit the health of women.

Adult↗
PubMed1989

[Measles].

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Humans↗
PubMed1986

Distribution of high density lipoprotein cholesterol according to relative body weight, cigarette smoking and leisure time physical activity. The Cardiovascular Disease Study in Finnmark 1977.

The relationship between HDL cholesterol and relative body weight, cigarette smoking and leisure time physical activity were examined in 7338 healthy men and 6768 healthy women aged 20-53 years, living in Finnmark County, Northern Norway. The independent effects of the three factors were examined by an analysis of covariance. In both sexes a strong and almost linear negative association was observed between relative body weight and HDL cholesterol. HDL cholesterol was lower in smokers than in non-smokers, the difference being more pronounced in females than in males. A weak but significant positive association was observed between leisure time physical activity and HDL cholesterol in both sexes.

Adult↗
PubMed1986

The Tromsø Heart Study: distribution of, and determinants for, gamma-glutamyltransferase in a free-living population.

Gamma-glutamyltransferase (GGT) was measured in 1579 men, aged 20-54 years, and 1654 women, aged 20-49 years, screened for coronary risk factors. The distribution was right-skewed with medians 15 and 10 U/l for men and women, respectively. Less than 3.8% of the men and 0.8% of the women had GGT greater than or equal to 50 U/l. The low level of GGT matched well with the low mortality of cirrhosis and the modest use of alcohol in Norway. Multiple regression analysis for each sex showed a strong positive association with body mass index, use of alcohol and, unexpectedly, a negative association with coffee consumption, whereas serum triglycerides and the time since the last meal showed a weaker positive association. In women, use of oral contraceptives was positively associated with GGT.

Adult↗
PubMed1985

Psoriasis: familial predisposition and environmental factors.

In a survey for coronary risk factors 14 667 adult men and women answered a questionnaire on lifestyle, diet, and health, including whether they had psoriasis. The overall prevalence of psoriasis was 4.79% in men and 4.85% in women. The data showed an increasing incidence of psoriasis. The association with family history, lifestyle, diet, and health was explored by multiple regression analysis. The occurrence of psoriasis in first degree relatives contributed to more than 90% of the explained variance for both sexes. Of the other variables, only the positive association with rheumatoid arthritis was significant in both sexes. It is concluded that the examined environmental factors have only minor effects on the prevalence of psoriasis.

Adult↗
PubMed1985

The Tromsø heart study: coffee consumption and serum lipid concentrations in men with hypercholesterolaemia: an randomised intervention study.

In a 10 week trial to assess the effects of coffee consumption and coffee brewing methods on serum cholesterol concentrations 33 men with hypercholesterolaemia were randomly assigned to: continue with their usual coffee intake; stop drinking coffee altogether; or stop drinking coffee for five weeks, thereafter drinking either boiled or filter coffee. Cholesterol concentrations fell significantly in all subjects abstaining for the first five weeks compared with subjects not giving up and continued to fall in those abstaining for 10 weeks. Cholesterol concentrations rose again in subjects returning to boiled coffee but remained the same in those returning to filter coffee. Abstention from heavy coffee drinking is an efficient way of reducing serum cholesterol concentrations in men with hypercholesterolaemia. The extent to which the brewing method affects this relation requires further study.

Adult↗
PubMed1985

The Tromsø heart study: coronary risk factors and their association with living conditions during childhood.

We examined the relation between questionnaire answers concerning living conditions during childhood and coronary risk factors in 7405 men and 7247 women. Poverty during childhood was positively associated with age-adjusted levels (p less than 0.05) of total cholesterol and percentage of current smokers (men only) and negatively associated with body height. When cholesterol was adjusted for age, body mass index, leisure time physical activity, coffee and alcohol consumption, and cigarette smoking there was a significant linear trend in women (p less than or equal to 0.0001) but not in men (p = 0.224). Analysing only subjects born in Troms county, giving a more homogeneous population, the linear trend became significant (p = 0.011) for men also. We conclude that childhood poverty followed by a high standard of living operates, at least partly, as a risk factor for coronary heart disease through conventional risk factors.

Adult↗
PubMed1983

The Tromsø heart study. Does coffee raise serum cholesterol?

We examined the relation between coffee consumption and levels of serum total cholesterol, high-density-lipoprotein (HDL) cholesterol, and triglycerides in a population of 7213 women and 7368 men between the ages of 20 and 54 years. Coffee consumption was positively associated with levels of total cholesterol and triglycerides in both sexes and was inversely associated with levels of HDL cholesterol in women. The coffee-cholesterol relation remained strong and statistically significant (P less than 0.0001 in a covariance analysis) after adjustment for age, logarithm of body-mass index, physical activity in leisure time, cigarette smoking, and alcohol consumption. After adjustment for all covariates, the total cholesterol level was 5.56 +/- 0.05 mmol per liter (mean +/- S.E.) in men drinking less than one cup of coffee a day, as compared with 6.23 +/- 0.03 mmol per liter in those consuming more than nine cups a day. The corresponding figures for women were 5.32 +/- 0.05 and 5.92 +/- 0.04 mmol per liter. None of the other variables considered could explain this relation. We conclude that coffee consumption is a major contributor to the variation in levels of total cholesterol.

Adult↗
PubMed1983

Pulmonary excretion of methanol in man.

An otherwise healthy methanol-poisoned male was treated with ethanol and forced diuresis. No acidosis or visual symptoms occurred. His blood ethanol concentrations varied between 10.7 and 30.0 mmol/l (0.49-1.38 g/l). His maximal blood methanol concentration was 14.4 mmol/l (0.45 g/l) and his plasma formate levels were within reference range (0.11-0.29 mmol/l). In a 24 h period where methanol metabolism was blocked by ethanol, the total body clearance and renal clearance of methanol were 11.3 and 5.7 ml/min, respectively. The difference, 5.6 ml/min, to a large extent reflects the pulmonary clearance of methanol thus being low in man.

Adult↗
PubMed1983

Serum lipids and glucose concentrations in subjects using antihypertensive drugs: Finnmark 1977.

As a side project to a study of coronary risk factors 4878 men and women aged 20-53 were interviewed about present and previous use of antihypertensive drugs. Serum lipid and glucose concentrations were compared in 124 present users, 73 previous users, and 124 controls matched for age, sex, and systolic and diastolic blood pressure. Users of betablockers, thiazides, and other antihypertensive drugs had higher total cholesterol, triglycerides, and glucose and lower HDL-cholesterol than the other groups, but only the difference in HDL-cholesterol was statistically significant. Smokers had statistically significant lower HDL-cholesterol than non-smokers in drug users, whereas there were only minor differences between them in previous and never users. This indicates an interaction between smoking and current antihypertensive medication. The unfavourable serum lipid pattern may, if caused by drug use, explain the lack of influence that antihypertensive treatment has had on the incidence of coronary heart disease in intervention studies.

Adult↗