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Biomedical subjects

D Prokopowicz

Publications and source records attributed to D Prokopowicz.

At least 109 records · Page 6Linked to original sources
PubMed1986

[Histopathologic and biochemical evaluation of the effect of cortisone on the liver in experimental post-alcoholic liver damage in the rabbit].

Possible protective effects of cortisone in experimental post-alcohol liver damage were evaluated in relation to dose and duration of treatment. Model examinations were undertaken in 100 rabbits divided into groups of 10. No protective effect of cortisone could be demonstrated. Treatment did not alter biochemical indices of liver function. Histologic examination revealed somewhat less extensive fatty changes following chronic alcohol exposure in animals receiving 1 mg cortisone per kilogram body weight.

Alanine Transaminase↗
PubMed1985

[Effect of alcohol on the development of biochemical and morphologic findings of liver damage in the rabbit].

Ethanol 48% was applied to the experimental model in 3 examined groups of rabbits in different periods of administration and differentiated daily doses on order to investigate the influence of ethanol upon the formation of morphological and biochemical indices of the liver lesion. Biochemical investigations were carried out on 3 and 7 day of the experiment and repeated at week by intervalls. All the animals were dissected and morphological examinations of the liver were carried out. Total analysis of the results obtained of the biochemical and morphological examinations of the liver in 3 analysed groups of animals proved that the biochemical index of postalcoholic lesion of the liver was a rise in guanase activity, and not in activity aminotransferases. In the investigations of fat balance, however the increase of triglycerides and cholesterol was observed. Morphological examinations showed post-alcoholic lesions of the liver, especially intensified in animals under longlasting alcohol influence, but in reducted doses.

Alanine Transaminase↗
PubMed1983

[Chronic alcoholism and infection with hepatitis B virus].

The study Hepatitis-B-virus infection was performed in the population of chronic alcoholics (224 persons). Among this population the HBs-antigenemia was proved in 42%. The immunoglobulin dysproteinemia and coexistence of autoantibodies can indicate a symptomatic Hepatitis-B-virus infection.

Adolescent↗
PubMed1983

[Some indices of organ reactivity in experimental trichinellosis. I. Granulocyte reactions in trichinellosis in rabbits].

The number of leucocytes, neutrophils and eosinophils was determined during one year observation in 34 rabbits after an infection with Trichinella spiralis in the doses of 15,000, 20,000 and 30,000 larvae. Granulocyte reactions were already observed on the third day after the infection, they lasted at least for 3 months and depended on the intensity of the infection.

Animals↗
PubMed1982

Effect of cortisone on the behavior of serotonin, 5-hydroxy-indoloacetic acid and monoaminooxidase in the liver tissue, the blood and the urine in experimental rabbit liver injury with CCl4.

The aim of this study was to investigate the effect of cortisone on the behavior of serotonin metabolism indicators in experiments carried out in rabbits. The following parameters were determined: the level of serotonin (5-hydroxy-tryptamine), (5-HT) in liver tissue and blood, the activity of monoamino-oxidase (MAO) in liver tissue and serum, and the level of 5-hydroxy-indoloacetic acid (5-HIAA) in liver tissue and in 24-hour urine of 52 rabbits. The experimental model involved acute liver injury with carbon tetrachloride--CCl4 and the effect of exogenous cortisone on the behavior of the above-mentioned indicators. On the basis of the experimental findings the authors demonstrate a dependence of serotonin metabolism on the liver injury, and an absence of normalization of the estimated parameters after cortisone administration.

Animals↗