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Biomedical subjects

D Prokopowicz

Publications and source records attributed to D Prokopowicz.

At least 127 records · Page 7Linked to original sources
PubMed1981

[Immunosuppressive treatment of chronic liver diseases in the clinical biochemical, immunological and histological evaluation of the liver].

The authors analysed the clinical states and the behaviour of clinical parameters in 36 patients with chronic liver diseases. The patients were treated with Encorton or Encorton associated with Imuran. The best clinical results as well as the tendency to normalisation were observed in the group of patients who were treated with Encorton and Imuran.

Adolescent↗
PubMed1981

[Immunomodulating action of levamisol preparation in the treatment of trichinellosis (author's transl)].

The effect of Levamisol administered to patients with trichinosis, the influence thereof on the behaviour of lymphocytes T and B in the peripheral blood as well as the clinical course of the disease were analysed. In the 4th week Levamisol was administered to the patients in doses of 150 mg/24 h for 3 days and the same dose was given for 7 days in the 2nd and 4th week of the disease. The control group included patients with trichinosis who had not been given any drugs to produce immunological processes. A slight decrease in the percentage of T lymphocytes in the peripheral blood was observed in patients who had received Levamisol, immediately after having begun treatment. An increase in the percentage of T lymphocytes was noted in the patients who were treated with the drug as early as in the 2nd week of the disease. In patients treated with Levamisol, subjective complaints were observed which, however, ceased soon afterwards. No side effects of the drug were found.

Adolescent↗
PubMed1979

[The behaviour of serotonin in blood, the activity of monoaminooxidase in serum and of 5-hydroxyindoloacetic acid in twenty-four hour urine in patients with viral hepatitis (author's transl)].

The level of serotonin in blood, the activity of MAO in serum and the value of 5-HIAA in 24 hour urine were estimated in 76 patients with viral hepatitis divided according to clinical parameters into three groups (mild, mild to severe and severe clinical course). A statistically significant increase of serotonin level in blood compared with the healthy control group was found. Highest values were observed in patients with the severe form of viral hepatitis. Decreased values of 5-HIAA in 24 hour urine in the early course of the disease showed a tendency to increase in later examinations. The activity of MAO in serum was significantly lowered in all clinical forms of viral hepatitis.

Adult↗
PubMed1979

Injury of liver in experimental salmonellosis of rabbits infected by salmonella agona.

Liver injury was investigated in the course of salmonellosis evoked by Salmonella agona in experimental infection of rabbits. Histological and biochemical examination (proteinogram, the level of bilirubin, fibrinogen, cholesterol and its esters in blood, activity of asparine and alanine aminotransferases and alkaline phosphatase and guanase in blood) were carried out in 70 animals. Liver injury showing degeneration, steatosis and necrosis was found in the course of salmonellosis. Hepatitis gigantocellularis was sporadically observed. Biochemical parameters were not in correlation with the observed histological changes.

Animals↗
PubMed1979

[The dynamics of humoral and cellular immunity changes in patients with acute phase of trichinellosis (author's transl)].

21 patients with acute trichinellosis have been studied. The behaviour of IgG, IgA and IgM in the serum of patients as well as the percentage of lymphocytes T and B was the aim of these studies. Statistically significant increase of IgG in serum has been observed since the third week of the clinical observation. During the whole period of observation the level of IgA was lowered--though the decrease was not statistically significant--whereas the level of IgM increased considerably. Decreased percentage of lymphocyte B in the peripheral blood during the first week of the clinical observation, later on increased significantly. The percentage of T lymphocyte was lowered during the whole period of the clinical observation of patients.

Acute Disease↗
PubMed1979

[The dynamics of the immunocytoadherence test with Trichinella spiralis-antigen in the experimental rabbit trichinellosis (author's transl)].

The authors analysed the dynamics of the immunozytoadherence test in experimental trichinellosis. The evaluation was carried out by mixing the lymphocytes of the infected rabbits with sheep erythrocytes encoated with antigen Trichinella spiralis. In three groups of infected rabbits (group I - 15 000 larves per rabbit, group II - 20 000 larves per rabbit, group III - 30 000 larves per rabbit) the examinations were performed 3, 6, 10, 20, 47, 82, 110, 140, 170 and 230 days after infection. It was observed that the maximum percentage of rosette occurred 10 days after infection. In the course of the observation the percentage demonstrated a tendency to decrease. The observed dynamics of the immunozytoadherence test indicates its value in diagnostic and prognostic evaluation of trichinellosis.

Animals↗