Genetic analysis of alfalfa mosaic virus mutants.
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Biomedical subjects
Publications and source records attributed to D Hartmann.
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A case of histopathologically proven Burkitt's lymphoma is described with special reference to clinical, serological and immunological features. This case report is followed by a review of the literature on the problem of American and African Burkitt's lymphoma. We can state that there is good correspondence between the white and black Burkitt's lymphomas with regard to epidemiology, histopathology, therapy and some immunological aspects. The two groups differ from each other in age, primary tumor manifestation, involvement of the bone marrow at time of diagnosis and quantitatively in the positive EBNA-test. It is therefore suggested that black and white Burkitt's lymphoma are not different diseases but different patterns of one disease.
Circulating immune complexes were detected in 62 individuals with malignant melanoma by precipitation with isolated human C1q and polyclonal rheumatoid factors. In 56 patients the C1q deviation assay showed low to moderate levels of complexes, with increased amounts with advancing stage of disease. Both heavy (greater than 19S) and intermediate (7S to 19S) varieties were present, and complexes containing tumor antigen-antibody or antibody-anti-antibody were identified. Complexes were found in the kidneys of one patient with malignancy and the nephrotic syndrome and in two further patients with melanoma in whom there were no clinical manifestations of nephrosis. Serial determinations in 51 patients showed slow cyclic variations in the levels of complexes and fluctuations in response to therapy. The coexistence of anti-antibodies, immune complex disease, and anergy in melanoma patients may indicate a deranged immune regulation consequent to chronic antigenic stimulation by the tumor.
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It is described a method of measurement of intrauterine pressure with perfusion of catheter by nonpregnant women. It is possible to prevent arteficial disturbances on account of obstruction of catheter.
The fate from children with a brithweight less than or equal to 2000 g in attendence of caesarean section is doubtful. From 35 children, born by caesarean section because of maternal and/or fetal indications died 17 (approximately 50 per cent). Maternal indication entitled always to perform sectio parva during the III. trimester of pregnancy--or to a earlier period. Clear fetal indication for caesarean section from the 34. week of gestation justified one-self. This is relative seldom. Caesarean section--performed before the 34. week of gestation--is changed with a high perinatal mortality and morbidity.
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