Search PubMed⌕ Search

Biomedical subjects

D F Scott

Publications and source records attributed to D F Scott.

At least 91 records · Page 5Linked to original sources
PubMed1980

Femoropopliteal vein grafts for intermittent claudication.

Femoropopliteal vein grafts were performed for intermittent claudication in 160 patients (182 legs) over a 12-year period. The accumulative patency rate was 67 per cent at 5 years. However, patency rates improved significantly in the latter 6 years of the study, to 75 per cent at 5 years. Early postoperative occlusion and morbidity rates also markedly declined in this latter period. Patency rates were significantly better in males than in females, in patients who were able to stop smoking after operation and in legs with a three-vessel run-off compared with those with a two- or one-vessel run-off. The patients' age did not influence graft patency rates.

Adult↗
PubMed1980

Massive haemorrhage caused by left renal vein ligation.

It is common practice to ligate the left renal vein during aortic surgery. Although this does not usually lead to complications we report 2 patients in whom left renal vein ligation caused massive venous congestion of the kidney and major retroperitoneal haemorrhage. Nephrectomy was necessary to control the haemorrhage. In 1 patient immediate autotransplantation preserved renal function.

Aged↗
PubMed1980

Light and electron microscopy of polytetrafluoroethylene arterial grafts in dogs.

Reinforced expanded polytetrafluoroethylene grafts with fibril lengths of approximately 17 to 25 micrometers were inserted into the infrarenal aorta of dogs for periods ranging from 24 hours to eight months. The grafts were studied by light and electron microscopy, which showed that polytetrafluoroethylene consists of ridges or nodes connected by fibrils. Initially red blood cells passed down in the pores of the polytetrafluoroethylene, and then the surface was covered with fibrin. A new endothelium developed by the twelfth day. The new intimal lining became thicker owing to the appearance of smooth muscle cells deep to the endothelial cells, forming a neointima 120 micrometers thick by eight months. Fibroblasts and collagen penetrated the graft, but vasa vasorum did not, although they were present in the external connective tissue.

Animals↗
PubMed1980

Femoropopliteal bypass using polytetrafluoroethylene.

Reinforced expanded polytetrafluoroethylene (PTFE) was used as a femoropopliteal bypass graft in 31 patients (37 operations). The indications were intermittent claudication (13 operations), severe ischaemia with rest pain or gangrene (20 operations), and prophylactic treatment of popliteal aneurysms (4 operations). The one-year accumulative patency rates were 75% for patients with intermittent claudication and 20% for patients with severe ischaemia. In three patients with claudication, graft thrombosis led to amputation in spite of attempted graft thrombectomy. These results compare unfavourably with our experience using autogenous vein, in which the one-year accumulative patency rates were 80% for claudication and 70% for severe ischaemia, and in which failure of the bypass graft for claudication rarely made the patient worse.

Aged↗
PubMed1980

Platelet monoamine oxidase activity in epilepsy.

The platelet monoamine oxidase activity (MAO) of 33 patients with epilepsy was compared with a group of neurological patients and a group of normal control subjects. We found that the MAO activity was increased significantly in the epileptic group when compared with the normal. This was not related to anticonvulsant medication. These results could be explained by the effect of epilepsy or anticonvulsant medication on the maturation of platelets.

Adult↗
PubMed1979

Intermittent peritoneal dialysis in the treatment of end-stage renal failure.

Our experience of 54 patients with end-stage renal failure, who were treated with intermittent peritoneal dialysis and compared with patients maintained by haemodialysis over the years 1972 to 1978, has been reviewed. All patients received peritoneal dialysis for more than six weeks. The total experience was 32.8 patient dialysis-years, 48% as home dialysis. Peritoneal dialysis was used as an interim procedure in 19 patients who were waiting for haemodialysis. However, in 35 patients (particularly in the very young and elderly, and in situations of poor social support), recurrent peritoneal dialysis was chosen as the definitive dialysis therapy. Dialysis was assessed as "adequate" in all, but two, patients. The major complication of peritoneal dialysis was peritonitis, although its over-all incidence of 1.31 episodes per patient dialysis-year was low. An attack of peritonitis occurred every nine months of patient exposure, though the incidence of bacterial peritonitis averaged only once every 26 months. Fifty per cent of patients never had an episode of peritonitis. Intermittent peritoneal dialysis was associated with greater morbidity and mortality than haemodialysis, perhaps due, in part, to the older age of the peritoneal dialysis group. Intermittent peritoneal dialysis is a valuable adjunct to haemodialysis and transplantation in the treatment of end-stage renal failure.

Adolescent↗
PubMed1979

Axillofemoral arterial bypass grafts.

The results of 24 axillofemoral arterial bypass grafts performed over a five-year period are presented. This extraanatomical technique of arterial reconstruction is valuable following removal of an infected aortic Dacron graft and for limb salvage or severe intermittent claudication in selected poor-risk patients with aortoiliac occlusive disease. There were few early patency rate was excellent, but the long-term success of the operation is uncertain.

Aged↗
PubMed1979

Living related renal transplantation: experience in 22 cases.

Twenty-two living related renal transplant operations have been performed at Prince Henry's Hospital over the last seven years. Donors have been accepted for nephrectomy only after exhaustive examination of their health and serach for renal disease. The one and three year graft survival rates have been 85% and 64% respectively. Only two recipients have died, and recipient morbidity has been low. Donors have not suffered any serious complication from nephrectomy. It is concluded that living related renal transplantation has many advantages over cadaveric renal transplantation and is a relatively safe procedure for the donor, provided that rigid criteria are used in donor selection.

Adolescent↗
PubMed1979

Oxacillin-induced lysis of Staphylococcus aureus.

Six clinical isolates of Staphylococcus aureus were compared for their relative susceptibilities to the killing effects of oxacillin. Three of the strains had minimum bactericidal concentrations which were >10 times the minimum bacteriostatic concentration for this antibiotic and were designated tolerant (Tol(+)). The other strains had minimum bactericidal concentrations which were comparable to the minimum bacteriostatic concentration (Tol(-)). Lysis curves of these strains revealed that the Tol(+) strains exhibited a diminished rate of lysis when inhibited by oxacillin. This reduced rate of lysis was reflected also in a reduced rate of viability loss when the cells were exposed to oxacillin. During log growth the uptake of [(14)C]glycerol by Tol(+) cells was 1.5-fold greater than that by Tol(-) cells. Glycerol-labeled cells of each phenotype secreted radioactivity when inhibited by oxacillin. However, the Tol(+) strains released over twice as much label as the Tol(-) strains. No difference in the proportion of lipid secreted by the two phenotypes was found. The behavior of 60 to 65% of the labeled material released by inhibited cells during both sodium dodecyl sulfate gel electrophoresis and Sepharose 6B chromatography corresponded to that of lipoteichoic acid. When the major component of secreted material was added to oxacillin-inhibited Tol(-) strains, an inhibition of the lytic response was observed. These results suggest that oxacillin tolerance in S. aureus could be related to the enhanced secretion of an autolysin inhibitor, such as lipoteichoic acid.

Bacteriolysis↗
PubMed1979

Value of EEG in acute confusional states.

Electroencephalograms of 95 patients with an acute confusional state, referred over three years, were studied to determine their usefulness. The majority were abnormal, and those from patients with intracranial pathology often showed asymmetry of delta activity and paroxysmal discharges. These, and other features, suggested that the EEG was a helpful investigation.

Acute Disease↗
PubMed1979

Pattern sensitive epilepsy: a case report.

A child with pattern sensitive epilepsy is reported. She had both absences and generalised seizures. The latter occurred spontaneously but the former followed concentration on patterned materials. These self-induced seizures appeared to have an affective component. The EEG showed generalised atypical spike and wave discharges both in the resting state and during intermittent photic and pattern stimulation. The patient responded to sodium valproate.

Child↗
PubMed1979

Assessment of peripheral arterial disease.

Atherosclerosis is epidemic in our community. Symptomatic peripheral arterial disease affects five to seven per cent of the population by retiring age. The major risk factors are smoking, high blood lipids and diabetes. A clinical history and examination of the peripheral pulses will precisely define the atherosclerotic occlusive lesions. Arteriography is only used as a preoperative measure in those patients requiring reconstructive vascular surgery.

Acute Disease↗