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Biomedical subjects

D Bergqvist

Publications and source records attributed to D Bergqvist.

At least 559 records · Page 31Linked to original sources
PubMed1983

Renal failure as a complication to aortoiliac and iliac reconstructive surgery.

A retrospective analysis has been undertaken of 17 patients among 221 who developed renal failure after aortic and/or iliac reconstructions because of occlusive disease (incidence 8%). In two renal artery occlusion was causing anuria, in the others tubular necrosis was considered to be responsible. This complication is multifactorial and factors of importance may be: operative trauma, haemorrhagic and other postoperative complications with reoperations, age and preoperative angiography. The patients with postoperative renal failure were older, the preoperative serum creatinine slightly higher, operation time longer and intraoperative haemorrhage greater than in patients without postoperative renal failure. Renal insufficiency after aorto-iliac reconstruction is a symptom with poor prognosis, the mortality being significantly higher (35%) than among the 204 patients without renal failure (2.0%). No simple dominating risk factor has been found in this material.

Adult↗
PubMed1983

Intracerebral haemorrhage after internal carotid endarterectomy.

This paper reports three fatal cases of intracerebral haemorrhage after internal carotid artery thrombendarterectomy, one in a patient operated on four weeks after a cerebral infarction and two in patients operated after a transient ischemic attack. Two other late intracerebral haemorrhagic events are reported in patients submitted to internal carotid artery surgery, one from a ruptured intracerebral aneurysm and another probably due to anticoagulation medication. It is emphasized to make a clear distinction between haemorrhagic and ischemic events when reporting stroke frequency in patient materials after internal carotid artery surgery.

Aged↗
PubMed1982

Comparison of the plasminogen activator activity of superficial hand and foot veins.

The plasminogen activator (PA) activity in superficial hand and foot veins was determined with a fibrin slide technique in 68 patients (46 with and 22 without thrombosis). The activity in the hand veins was identical to that of the foot veins in 57% of the patients and higher in 38%. There was a correlation between activity in hand and foot veins in patients with and without thrombosis. Thus, biopsy specimens from superficial hand veins can be used for assessing the PA activity in patients with leg thrombosis.

Adolescent↗
PubMed1982

Comparison between commercial heparin, low molecular weight heparin and pentosan polysulfate on hemostasis and platelets in vivo.

The effect of commercial heparin (MW 15000; 60 U/kg), low molecular weight heparin (MW 4500, 60 U/kg), sodium pentosan polysulfate (PZ-68) in doses of 0.5, 1, 2 and 5 mg/kg and 1 mg/kg combined with dextran 70 (0.5 g/kg) on microvascular hemostasis and platelet activity in vivo was investigated in the microcirculation of rabbit mesentery and ear chamber, respectively. Low molecular weight heparin did not alter the hemostasis: nonetheless, commercial heparin and PZ-68 interfered with the hemostatic mechanism by decreasing the stability of the hemostatic plug. This abnormality was more apparent in the venular than in the arteriolar system. Both heparins exhibited a trend towards an increase in platelet reactivity and the reverse was observed following the administration of PZ-68.

Animals↗
PubMed1982

Assessment of antithrombotic properties of sodium ibuprofen.

The effect of sodium ibuprofen on platelet activity in vivo and the lysability of ex vivo thrombi was investigated. The formation of a hemostatic platelet plug in the rabbit mesentery and platelet embolism as a response to a laser-induced injury in the ear chamber of rabbits were used as models for determining platelet activity. Ibuprofen at a dose of 25 mg/kg i.v. was found to increase the primary (PHT) and the total hemostatic plug formation time (THT). The same dose decreased the number of cumulative emboli over a 10 min period after a laser injury to arterioles. A dose of 10 mg/kg i.v. did not affect the formation of the hemostatic platelet plug. In dogs, doses of 10, 25 und 50 mg/kg did not enhance the release of 125I-FDP from the thrombi after incubation in plasmin, but the largest dose which is approximately five times the recommended dose in humans, did significantly decrease the thrombus weight 90 and 180 min after the drug administration. In conclusion, sodium ibuprofen was shown to have an inhibitory effect on platelet function in vivo and in large doses was also found to diminish the thrombus weight.

Animals↗
PubMed1982

After-exercise thermography and prediction of deep vein thrombosis.

A total of 112 patients participated in a prospective study of after-exercise thermography as a screening method for predicting risk of postoperative deep venous thrombosis. The fibrinogen-uptake test was used to detect thrombosis after elective surgery. The incidence of the complication showed no significant difference between patients who had had positive and those who had had negative thermograms. Thermography does not seem to be useful for predicting risk of postoperative thrombosis.

Aged↗
PubMed1982

Oral contraceptives and venous thromboembolism.

In 58 patients with phlebographically diagnosed deep vein thrombosis during oral contraception the extension and localization of the thrombotic process was analysed in relation to the coagulation and fibrinolytic system 6 months after thrombosis. Left-sided thrombi dominated and the thrombi were more extensive and proximal on the left side. This left-sided dominance was more apparent with higher oestrogen content in the pills. The right-sided thrombi more often were the source of pulmonary embolism. In 31% of the patients a defective fibrinolytic system was found; this defect was seen more often in patients with right-sided thrombi. Only very few defects were found in the coagulation system. No patients had an antithrombin III deficiency.

Adolescent↗
PubMed1982

Abdominal injury from sporting activities.

The frequency of abdominal injury is rising. In an analysis of 1,354 cases of closed abdominal trauma sustained during a 30-year period (1950-1979) in Skaraborg County, Sweden, a distinct increase was found in the numbers associated with sporting activities. The severity of the injuries caused by sports likewise showed an increase. The representation of injured organs was of the same order as in the total series of closed abdominal injuries. An analysis of the 136 cases of sports-associated injury is presented with regard to cause and type of the injuries, diagnosis and prognosis.

Abdominal Injuries↗
PubMed1982

Effect of acute ethanol intoxication on primary haemostasis, coagulation factors and fibrinolytic activity.

The effect of ethanol intoxication on haemostasis was studied by transection of mesenteric microvessels and liver resection in the rat. Plasma concentrations of alcohol were within the range of those found in ethanol intoxication in man. Bleeding time and blood loss were increased 1 h after ethanol administration, regardless of the utilized technique. A significant positive correlation existed between bleeding time following liver resection and bleeding time after simultaneous transection of a mesenteric arteriole and venule. Coagulation mechanisms, assayed by whole blood clotting time, APT time, one-stage prothrombin time, recalcification time, thrombin time, Owren's P & P test and determination of plasma factor V and fibrinogen levels, were not significantly changed in ethanol-intoxicated animals. Administration of alcohol did not affect fibrinolytic activity, while it inhibited significantly ADP and collagen-induced platelet aggregation in the rat.

Alcoholic Intoxication↗
PubMed1982

Venous insufficiency as a late complication after tibial fracture.

Thirty-eight patients were followed up 13 to 17 years after sustaining a fracture of the tibia. The aim was to establish the frequency of post-thrombotic venous insufficiency. All patients were examined clinically and with a modified ultrasound technique. In addition some were studied using phlebography. Fifteen patients had symptoms of venous insufficiency in the fractured leg. Seven had only local symptoms, while in the other eight the venous insufficiency was verified objectively. The following factors predisposed to the development of venous insufficiency: Age above 45 years at the time of trauma, a high energy trauma resulting in comminuted fractures, and a long immobilization period.

Adult↗
PubMed1982

Prophylaxis of deep vein thrombosis in patients with fracture of the femoral neck: a prospective comparison between dextran and a sulphated polysaccharide.

A prospective and randomized study of 100 patients with fracture of the femoral neck was carried out. The aim was to compare the thromboembolic prophylactic effect of dextran 70 and a sulphated polysaccharide, PZ 68. Deep vein thrombosis was diagnosed using the 125I-fibrinogen test and phlebography, and pulmonary embolism with a perfusion and ventilation scan. The number of thromboses and emboli did not differ significantly between the two groups. However, there was a general tendency for predominance of thrombosis on the operated side. Six patients were excluded in the PZ 68 group because of major haemorrhage.

Aged↗