[Prevalence of endemic yaws in southern Benin in 1982].
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Adolescent↗
Biomedical subjects
D Baudon
Publications and source records attributed to D Baudon.
Serum enzymes profile in human acute myeloblastic leukaemia: preliminary results.
Serum enzymatic activities in 18 human acute myeloblastic leukaemias were tested using a semiquantitative micromethod: the activities of 5 enzymes were observed to be changed.
Humans↗
Efficacy of daily antimalarial chemoprophylaxis in tropical Africa using either doxycycline or chloroquine-proguanil; a study conducted in 1996 in the French Army.
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Adult↗
Population genetics of abnormal haemoglobins in Burkina Faso, west Africa.
The gene frequencies of haemoglobin A (HbA), HbS and HbC were studied in Burkina-Faso (BF) and in a neighbouring region of Niger, Ayorou. The frequency of HbS was higher in the Sahel region, (northern part of BF and Ayorou) than in the Savanna region. The reverse was true for the HbC gene. The major findings of this study are: (a) confirmation of a peak of HbC gene frequency in the central region of BF (Mossi plateau); (b) a possible negative correlation between the frequencies of HbS and HbC-Cavalli-Sforza and Bodmer have observed that this correlation is at a significantly different level from that expected because of the allelic relationship between HbS and HbC; (c) comparison with the data collected by Livingstone shows a modification in the fitness of the different genotypes in the last thirty years: AS individuals have a lower and AA and SS a higher fitness. Our data favour a partial selection relaxation in this region.
Burkina Faso↗
Jail fever (epidemic typhus) outbreak in Burundi.
We recently investigated a suspected outbreak of epidemic typhus in a jail in Burundi. We tested sera of nine patients by microimmunofluorescence for antibodies to Rickettsia prowazekii and Rickettsia typhi. We also amplified and sequenced from lice gene portions specific for two R. prowazekii proteins: the gene encoding for citrate synthase and the gene encoding for the rickettsial outer membrane protein. All patients exhibited antibodies specific for R. prowazekii. Specific gene sequences were amplified in two lice from one patient. The patients had typical clinical manifestations, and two died. Molecular techniques provided a convenient and reliable means of examining lice and confirming this outbreak. The jail-associated outbreak predates an extensive ongoing outbreak of louse-borne typhus in central eastern Africa after civil war and in refugee camps in Rwanda, Burundi (1), and Zaire.
Adult↗
[Chemosensibility of Plasmodium falciparum in Africa south of the Sahara: evaluation of two and a half years' research at the Tropical Medicine Institute of the Health Service of the French Armed Forces].
From March 1987 to June 1989, 194 isolates of Plasmodium falciparum were studied in vitro by the isotopic semi-microtest. 86.1% were resistant to chloroquine; 9.5% had a decrease of sensibility to quinine and 3.3% a decrease of sensibility to mefloquine. There was a positive correlation between I.C. 50 of the antimalarial drugs compared by pairs.
Adolescent↗
[The Quantitative Buffy Coat test (Q.B.C. test). Monofluo Kit Falciparum. Comparative value in the rapid diagnosis of malaria].
New emerging atypical forms of malaria, characterized by weak parasitemia, among peoples without premunition, back from Plasmodium falciparum resistant areas, make it necessary to use rapid, sensitive, reliable methods of parasitologic diagnosis. This work concerned two different populations: 394 expatriates back from a 4 months stage in endemic areas. 12 patients admitted for suspected of proved malaria. Authors have studied, by double blind method, versus thin film, two fluorescent techniques: a direct immunofluorescence, the Monofluo kit Falciparum of Diagnostic Pasteur. A nucleic acid fluorescence, on blood samples centrifuged in capillary tubes, the Q.B.C. test of Becton-Dickinson. Both methods seem of great interest for epidemiological surveys. The Q.B.C. test has showed more sensitivity than the thin film: it's rapidity of realisation indicates it for urgent diagnosis.
Animals↗
[A study of malaria morbidity in a pediatric hospital service in Benin (West Africa) in 1988 and 1989].
Authors report on a prospective study about malaria morbidity, carried out from April 1988 to March 1989. Malaria diagnosis was based on: 1. An unexplained fever, hours before, during or after entrance. 2. A parasitic density superior to 3,000 trophozoites per mm3 of blood. 3. Efficacy of parenteral malaria therapy. Among 480 hospitalized children, 20% suffered from a malaria attack; 44% of malaria attacks occurred within 6 and 23 months of age. Thus, malaria incidence seems considerable in this urban and lagoon environment. Malaria attacks were observed all year long but with unequal seasonal rates of incidence. As regards malaria morbidity studies, we propose that rates of incidence should be calculated according to several parasitic density thresholds so as to be able to compare various works.
Africa, Western↗
[The cereals. A dietetic menu].
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Diet Therapy↗
[How to evaluate the epidemiologic importance of malaria in an endemic zone. Example of a savannah area in western Africa].
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Antimalarials↗
[Fresh fruit with a median content of glucides (8 to 15%). A dietetic menu].
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Diet Therapy↗
[Malaria morbidity in rural and urban areas in Senegal].
During September and November 1987, the authors surveyed the incidence of malaria fever in populations of a rural zone in Casamance and in adults as outpatients in an urban area. In these regions, the malaria is endemic with a recrudescence during the rainy season from July to October. In rural zone, 169 persons were examined. The malaria fevers represented 7.1% of the consultations and 23.3% of fevers. Differences were significantly observed between the parasitic densities of febrile and afebrile patients.
Adolescent↗
[Epidemiological value of graphic representation of the Tukey test].
The method of Tukey shows a graphic view of a distribution of data around its median. This graphic representation is simple, easy, pertinent and computer-compatible. It optimizes the description of distribution of data (normal or free distribution). Usable with small size samples, the Tukey test is not very powerful, but robust, and authorizes a comparison of two or more medians with a risk of 5%.
Data Interpretation, Statistical↗
[Reliability of clinical studies in the diagnosis of malaria fever in West African endemic areas].
We have studied 930 febrile cases in a savanna area of Burkina Faso. We have diagnosed malarial fevers according to the only clinical data in 333 cases and it was confirmed in 154 cases by parasitological study; for 597 cases a non malaria reason was given according to the only clinical data and it was confirmed in 507 cases by biological studies. On the whole the error rate was of 28% on the clinical examination alone and this proportion was equal or superior whatever the parasitological threshold was. The clinical examination is not allow by it self to diagnose a malaria fever case.
Animals↗