Search PubMed⌕ Search

Biomedical subjects

D Baudon

Publications and source records attributed to D Baudon.

At least 55 records · Page 3Linked to original sources
PubMed1987

[The OCCGE (Organisation de Coordination et de Coopération pour la Lutte contre les Grandes Endémies) and the surveillance of the drug sensitivity of Plasmodium falciparum to antimalarials].

Spreading of chemoresistance from East Africa to Central Africa is a very worrying problem for Western Africa. In fact, chemotherapy of febrile attacks is at present admitted as malaria control strategy in the framework of Primary Health Care. This new strategy is based on the fact that commonly used antimalarial drugs as chloroquine are surely efficacious. Thus, the surveillance of chemosensitivity of Plasmodium falciparum local strains becomes a priority. From studies carried out in Burkina Faso during many years, Centre Muraz of O.C.C.G.E. has organized a surveillance system with several levels: a Reference Center, a National Center for each country and sentinel centers located in the different epidemiological features of the countries. This surveillance concerning many states can allow to detect more quickly some possible problems in relation with chemoresistance and to take measures to limit its impact.

Africa, Western↗
PubMed1987

[Surveillance of the sensitivity of Plasmodium falciparum to chloroquine in Western Africa: value of in vivo tests using 5 and 10 mg/kg].

Studies on the in vivo sensitivity of Plasmodium falciparum strains to chloroquine were carried out on shrub savanna areas of Burkina Faso, West Africa and were conducted from 1982 to 1986 in asymptomatic malarial school children. From the result of 431 in vivo tests using a single dose of only 5 or 10 mg/kg b. w. chloroquine base, it was concluded that there was a high sensitive response of P. falciparum to chloroquine. In areas where clinical resistance has not been established, and where there is a high sensibility in the response of P. falciparum to chloroquine, in vivo studies with a single dose of 5 or 10 mg/kg are probably able to detect a decrease of sensitivity before the appearance of clinical resistance to higher regimens.

Africa, Western↗
PubMed1987

[Control of malaria in Africa: from the eradication of malaria to the control of malaria].

The control strategies usually recommended in Africa south of the Sahara have not been followed by a lasting decline in the endemic level of the disease in the rural environment. The set-backs of the eradication period have revealed the need to redefine control objectives and strategies adapted to each type of malaria. Systematic chemotherapy for attacks of fever is a strategy that can be proposed in all circumstances; it avoids mortality from malaria; it can be carried out in the field on a country scale. The other means of control, directed against the parasites and the vectors, may be used depending of the specific situation in each country and on each type of malaria. Malaria control has to be integrated into the basic health system of each country, and we need to improve health education and develop primary health care. We must continue with our efforts to develop new antimalarial drugs, insecticides and vaccines; urgent steps must be taken to train malariologists capable of adapting the new techniques to the actual situation in the field. It is by associating socioeconomic development with the control means as a whole that we shall be able to control the various types of malaria and to reach out towards the objective of health for all by the year 2000.

Africa↗
PubMed1986

Acute respiratory infections: a longitudinal study of 151 children in Burkina-Faso.

A longitudinal study of 151 children under five years of age was performed in a rural village of Burkina-Faso (West Africa). During systematic examinations by a physician during the rainy season, 44% of the children were found to be ill and 59% of these had an acute respiratory infection (ARI). During the dry season, the rates were 48% and 73% respectively. Weekly interviews by a field worker showed 6.2 attacks of ARI during the six months of the rainy season and 7.0 during the six months of the dry season. Risk factors for ARI were malnutrition assessed by arm circumference, and a high birth rank. At the 'field-dispensary', ARI accounted for 41% of the visits; lower respiratory infections (LRI) accounted for 24%, similar to the proportion of LRI among illnesses found during the systematic examination.

Acute Disease↗
PubMed1986

[Impact of building a dam on the transmission of malaria. Malaria survey conducted in southeast Mauritania].

In March during the dry season an investigation was conducted on the site of Foum Gleita dam in the Islamic Republic of Mauritania in order to study, one year after the filling of the dam, the epidemiological situation of local malaria at a clinico-parasitological, immunological and entomological level. No malarial transmission was observed in the 5th month of the dry season. So far, the damming of water has not led to the spread of anophelines which would have brought about malarial transmission not within the rainy season.

Adolescent↗
PubMed1985

[Extent of endemic yaws in Upper Volta in 1981].

This yaws investigation has been realized in the South West of Upper-Volta, in 1981, in areas around Gaoua, Niangoloko, N'Dorola; this investigation concerns 15 villages, chosen at random, and a sample of 1540 persons older than 4 years. The clinical prevalence (infectious cases) is 0.6%; the higher prevalence is observed around Gaoua (1.5%). Infectious contagious lesions are found especially in the 5-14 years old group. This investigation shows a low prevalence (under 5%) of active yaws. The serological prevalence (Kline-test) is 5.8% and we observe also around Gaoua the highest prevalence (8%). Periodical screening surveys of the population, during years 1952-1957, had shown a low prevalence of yaws, with a medium prevalence of yaws around Gaoua. Yaws treatment campaigns had been realized from 1957 to 1960 in South-West of Upper-Volta with very good results (prevalence: 0.06% - 1960). Now, in 1981, we note a resurgence of endemic foci, especially around Gaoua, from where the infection is spreading again, this, threatening the gains made by previous mass treatment campaigns. Taking in account the present result, it is necessary to treat contagious cases and contact sick persons (selective mass treatment or S.M.T., recommended in areas of low prevalence, by the WHO scientific group on treponemal infections).

Adolescent↗
PubMed1985

[Use of stabilized yellow fever vaccine 17D at the time of the yellow fever epidemic in Burkina Faso in 1983].

During the 1983 yellow fever epidemic in Burkina Faso, vaccinations were performed with a stabilized yellow fever 17D vaccine. Samples of vaccine were collected in different places during the vaccination campaigns. The virus titers of these samples were compared with those of vaccine samples of the same batches stored at--20 degree C in the Institut Pasteur in Dakar. There was no significant decrease of the titer when the vaccine had been stored in the conditions recommended by the expanded programme on immunization. The results confirm the experimental data on the stability of this vaccine. A serological survey carried out in young children showed that about 90% have hemagglutination inhibition antibodies following the vaccination.

Burkina Faso↗
PubMed1985

[Endemic syphilis in a Sahelian area of Burkina Faso. Sero-clinical survey].

In March 1981, we studied a traditional focus of endemic syphilis in a Sahelian area in North-East of Burkina-Faso. The clinical survey was conducted on a sample of 1 600 people and showed a prevalence of contagious clinical lesions of 5.6% in children and 1.8% in adults. The seroimmunological study, effected with passive haemagglutination test (T. P. H. A.), showed that 47.1% of the individuals were bearing antitreponemic specific antibodies; the seroimmunological prevalence increases with age, from 29.2% in the 5-9 years old children up to 85.2% in adults 60 years old and over. Clinical and serological prevalences are all the more important as the conditions of hygiene are worse. In comparison with the last campaigns of penicillinotherapy, conducted in 1962, a recrudescence of syphilitic endemic is to be noted.

Adolescent↗
PubMed1984

[Sensitivity of Plasmodium falciparum to chloroquine in the hyperendemic malaria savannah zone of Burkina Faso ex-Upper Volta. Use of in vivo and in vitro tests. Demonstration of a resistant strain in vitro].

Studies on the response of P. falciparum to chloroquine was conducted in schools located in the environs of Koudougou (Burkina Faso, Upper-Volta), where malaria is meso to hyperendemic, using in vivo studies and in vitro macroculture tests. Cases were obtained from school children, semi-immune asymptomatic carriers, in the 7-12 years-group.

Burkina Faso↗